Welcome to My AP Biology Thoughts podcast, my name is Nikki Evich and I am your host for episode

#82 called Unit 4 Cell Communication and Cell Cycle: Intro to Signaling Transduction Pathway. Today

we will be discussing the components that make up a pathway.

● Signal also call ligand binds to a receptor on target cell membrane

○ , starts the pathway,

○ had to fit receptor,

○ once bound, transduction is initiated

● Receptor- intracellular or extracellular

○ Binding domain recognizes specific chemical messengers

● transduction-lots of varian with transduction

○ Could activate inactive protein by phosphorylating

○ Amplifies with secondary messengers

● Response- what the end result is

○ Can be short or long

○ Activate enzyme or move cell-short

○ Alter gene expression levels or cell division (apoptosis)-long

● Type 1

● Once the food is broken down into glucose, these molecules are then absorbed into the bloodstream.

The high glucose levels in the bloodstream activate the beta cells in the pancreas to start producing

insulin. Insulin is a hormone created in the pancreas. In the pancreas, beta cells are present which are

in charge of secreting the insulin into the bloodstream once they detect an increase in blood glucose.

Insulin travels to three main destinations-muscle, fat, and liver cells.

● This is where the transduction pathway happens

● The insulin will then bind to the insulin receptors. The insulin receptors are made up of extracellular

alpha subunits and transmembrane beta subunits.

● When the insulin binds to the extracellular alpha subunits, the beta subunits become activated and auto

phosphorylate. This means that they phosphorylate themselves.

● This leads to the phosphorylation and activation of the IRS protein. The IRS protein is regulated and

can be phosphorylated by PTEN. PTEN can regulate phosphorylation and activate IRS Isaforms...