Iran has fired hundreds of missiles and drones at targets across the Middle East, after announcing that its Supreme Leader, Ayatollah Ali Khamenei, has been killed in US-Israeli attacks. At least 200 people -- most of whom were at a girls' school in the country's south -- have been reported killed in Iran. Three US service personnel have been killed in Iran's response, as well as ten people in Israel. Donald Trump has suggested that Iran's new leadership wanted to talk. Meanwhile, UK government officials are understood to be working on plans to potentially evacuate British nationals from the Middle East.