Should every information systems research paper be relevant to practice? Does research need to be relevant in the first place? And if relevance is relevant, how should we engage with practitioners about our research? We discuss relevance of information systems research, how the field's view of relevance may have changed and what researchers might do if they wish to be relevant to practice. As usual, the readings we refer to are listed on http://www.janrecker.com/this-is-research-podcast/.