JACI: In Practice Editor Robert Zeiger describes the January issue, the theme of which is “Inhalant Allergen Immunotherapy”. Theme topics covered include the art of immunotherapy, allergen immunotherapy for asthma, allergen immunotherapy for allergic rhinitis, impact of allergen immunotherapy on the progression of airway disease, and mechanisms and predictive biomarkers of allergen immunotherapy. Dr. Zeiger then presents the Highlights of the Original Articles in the issue, which are on the topics of Immunotherapy, Anaphylaxis, Artificial Intelligence, Asthma, Drug Allergy, Food Allergy, Immunodeficiency, and Urticaria and Angioedema.