Explore a groundbreaking single case study from 2025 on ketamine-assisted psychotherapy (KAP) for the notoriously challenging anorexia nervosa (AN). Discover how KAP, coupled with Acceptance and Commitment Therapy (ACT), potentially creates a “neuroplastic window” for change in rigid thought patterns. The case study reveals marked symptom reduction in AN pathology, depression, and anxiety, alongside improved quality of life for one patient. This unique case highlights the critical synergy between ketamine and therapy for sustained gains, while also navigating complexities like post-treatment weight loss and a subsequent psilocybin experience. It’s a powerful glimpse of hope for treatment-resistant conditions, demanding further rigorous research.

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De Smet, L., De Schryver, M., Roekens, L., Van Vlierberghe, L., Dierckx, M., Van Renterghem, K., Van Ryckeghem, D., & Kiekens, G. (2025). Transdiagnostic ketamine and psycholytic psychotherapy for patients with co-occurring depression and eating disorder: study protocol of a randomized controlled trial. Journal of Eating Disorders, 13(1), 108. https://doi.org/10.1186/s40337-025-01313-y