Apparently Jody doesn't know how to let it go. Listen as he rants about incidents from the distant past that still get under his skin. If you observe Festivus, consider this an early airing of grievances.

Sound effects by Voicemod.

The new PCAB Voquenza (vonoprazan) is being marketed as a superior alternative to PPI therapy for acid-related conditions (GERD with or without erosive esophagitis, H. pylori eradication). Are these two mechanisms of action really that different? Jody investigates.

References:

1) Prescriber information: https://www.phathompharma.com/wp-content/uploads/VOQUEZNA-tablets-Prescriber-Information.pdf

2) György Miklós Buzás, Dual acid-pump blocking as novel therapeutic approach to treatment of acid-related diseases, Medical Hypotheses, Volume 187, 2024, 111338, ISSN 0306-9877, https://doi.org/10.1016/j.mehy.2024.111338.

3) Katzka DA, Kahrilas PJ. Potassium-Competitive Acid Blocker Suppression of Gastric Acid in Erosive Esophagitis: Is Stronger and Longer Better? Gastroenterology. 2023 Jan;164(1):14-15. doi: 10.1053/j.gastro.2022.10.022. Epub 2022 Oct 28. PMID: 36341738.

4) Shin JM, Sachs G. Pharmacology of proton pump inhibitors. Curr Gastroenterol Rep. 2008 Dec;10(6):528-34. doi: 10.1007/s11894-008-0098-4. PMID: 19006606; PMCID: PMC2855237.

5) Simadibrata DM, Syam AF, Lee YY. A comparison of efficacy and safety of potassium-competitive acid blocker and proton pump inhibitor in gastric acid-related diseases: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2022 Dec;37(12):2217-2228. doi: 10.1111/jgh.16017. Epub 2022 Oct 26. PMID: 36181401; PMCID: PMC10092067.

6) Oshima T, Miwa H. Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases. J Neurogastroenterol Motil. 2018 Jul 30;24(3):334-344. doi: 10.5056/jnm18029. PMID: 29739175; PMCID: PMC6034668

During the week prior to Hurricane Ike making landfall in Texas, paramedics from all over the country helped evacuate patients from the storm's path. In this episode of Critical Incident from Knowledgeable Provider, Jody shares his personal experiences from that response.

It's back-to-school time! Are you ready? Jody shares his suggestions for passing those exams with flying colors.

How To Study A Textbook by Tom Meyer

The sad story of a patient whose diagnosis was delayed until it was too late.

Requested by KP listeners! An update on a patient from the previous prostate cancer episode and a deep dive into the history of prostate cancer screening.

References:

Angie Carmody is an American Sign Language interpreter with Huntsville City Schools in Huntsville, Alabama. She talks with Jody about her years of experience in the field and offers some helpful insights about communicating with deaf people.

Links:

Alabama Institute for the Deaf and Blind

Deaf Access Solutions

Stayawhile Cabin Rental (Vrbo)

Stayawhile Cabin Rental (airbnb)

Dr. Oyen and Jody swap "war stories" from their EMS careers. Crazy codes, celebrity encounters, the Olympics, hurricanes, non-human patients; you really never know what you're going to run into out in the field.

Jody shares his general approach to managing hypertension in primary care.

Links:

2020 IHS Hypertension Guidelines

2023 EHS Hypertension Guideline Update

Racial & Ethnic Disparities in Hypertension