Life Optimized

In this episode of the Life to Optimize Podcast, Dr. Neil Pop discusses two main topics: bioregulators and a new peptide called SS-31 (or Elamipretide). Bioregulators, which have been around since the Cold War, are small proteins that work on specific DNA sites to regulate gene expression and DNA methylation, promoting health and longevity.

SS 31 is a mitochondrial peptide with antioxidant and anti-inflammatory properties, currently undergoing extensive research. It shows promise in heart health, tendon and joint healing, and potential benefits for Alzheimer's and brain health.

Show Highlights:

• What are bioregulators?
• Ideal dosages and duration for taking bioregulators.
• The best place to get bioregulators and peptides.
• What is SS-31 and how can it help you?
• Can Elamipretide help your brain and prevent Alzheimer's?
• The surprising benefits of SS-31 and other similar peptides.

Resources

Connect with Dr. Paulvin

https://doctorpaulvin.com/

Today’s episode is all about supplements. We’ll be discussing different kinds of supplements, which ones you should stay away from, and what makes supplements the way they are.  Listen and find out about Spermidine, Urolithin A, and more supplements that can help you in the future.

Show Highlights:

• What are supplements?
• What kind of supplements are out there?
• Which one’s are good and bad?
• What’s Spermidine?
• Urolithin A and why it’s a strong supplement.
• What’s Butyrate?
• The two supplements that improve overall health and longevity
• How sleep influences supplemental care

Supplements mentioned in this episode:

• Spermidine
• Urolithin A
• Butyrate
• Resveratrol
• Apigenin
• Metformin

Resources

Connect with Dr. Paulvin

https://doctorpaulvin.com/

Dr. Hill is one of the top peak performance coaches in the country. He holds a Ph.D. in Cognitive Neuroscience from UCLA’s Department of Psychology and continues to do research on attention and cognition. Research methodology includes EEG, QEEG, and ERP. He has been practicing neurofeedback since 2003.

In addition to founding Peak Brain Institute, Dr. Hill is the host of the Head First Podcast with Dr. Hill and lectures at UCLA, teaching courses in psychology, neuroscience, and gerontology.

Show Highlights:

• Learn how you can use neurofeedback to optimize brain function
• Can neurofeedback treat ADHD?
• How does Neurofeedback work?
• Discover the science behind brain mapping and how it can identify areas of the brain that need attention.
• How long do the benefits of neurofeedback last?
• Is it possible to train your brain for higher achievement?
• What does AI mean for the future of neurofeedback?
• How to be the best version of yourself

• Peak Brain InstitutePeak Brain Institute - Brain Gym & Peak Performance Center

Resources

Connect with Dr. Paulvin

https://doctorpaulvin.com/

Ryan Smith received a BA in biochemistry from Transylvania University before heading to medical school in 2013. After passing USMLE Step 1, he decided to leave and open up a pharmacy in the United States that focused on peptide synthesis and formulations for pharmaceutical preparations. That pharmacy, Tailor Made Compounding, became the 4th fastest growing company in healthcare in the US and grew to 80 million in revenue within 3 years. Ryan exited Tailor Made in 2020 to create TruDiagnostic. 

TruDiagnostic is a CLIA certified lab and health data company which specializes in understanding and reporting insights found through Epigenetic methylation data. TruDiagnostics has also led research in the field with over 30+ clinical trials investigating the best ways to reverse these markers through diet, lifestyle, and prescription interventions. Currently, TruDiagnostic is working with collaborators from Duke, Harvard, Yale, UCSF, Ohio St. and more to uncover new insights from the methylome. TruDiagnostic is also the only commercial company on the market to offer 2nd or 3rd generation aging algorithms which have shown to be more predictive and precise than 1st generation aging clocks.

Show Highlights:

• The current state of anti-aging medicine
• Why it's important to measure biological age accurately
• The best measurement tools for anti-aging
• Why you should start testing your biological age as early as possible
• What data can tell us about the health of an individual beyond aging
• Which lifestyle changes will be most helpful for optimizing your health span

Resources

Connect with Dr. Paulvin

https://doctorpaulvin.com/

• TruDiagnostic™ | Advanced Epigenetic Testing

In today's show I talk to Dr. Jay T. Wiles about Heart Rate Variability. We go really deep into all the aspects of HRV. From measuring it accurately to optimizing the factors that affect it. Everything you need to know and more!

Dr. Jay T. Wiles is a clinical health psychologist, currently working as the Health Behavior Coordinator at WJB Dorn VA Medical Center in Columbia, SC and the Greenville Outpatient VA Clinic. He has specialized training in health behavior coaching, health assessment, nutritional interventions for mental and physical health, Motivational Interviewing, applied psychophysiology, and consultation. Dr. Wiles works as a consultant for companies/organizations, practitioners, and individual patients on nutritional psychology, health behavior change, applied psychophysiology, and health promotion/disease prevention via complementary and integrative practices.

Show Highlights:

• What is Heart Rate Variability, and why should you measure it?
• How to measure your Heart Rate Variability
• The common problems with wearable technology
• Optimal ranges for your HRV
• How to interpret your biometric data
• What affects your HRV both positively and negatively
• The surprising connection between HRV and mental health

Resources

Connect with Dr. Paulvin

https://doctorpaulvin.com/

• Home - Hanu Health, Inc. - Use code DRPAULVIN for 20% off

Today’s episode is a deep dive into peptides. There has been a lot of hype in the Biohacking community around these amazing products. Research is quickly evolving, and keeping up with the latest developments can be difficult. Listen and learn how you can get the most out of peptides to help with your healing and recovery.

Show Highlights:

• What are peptides?
• How should you take peptides?
• The best peptides for pain and recovery
• Are there risks to taking peptides?
• The Wolverine Stack – the ultimate in regenerative healing
• How to use peptides to lower inflammation
• Why you need to pay attention to mitochondrial peptides

Peptides discussed in this episode:

• Thymosin Alpha 1
• Thymulin
• BPC157
• CJC 1295
• Melanotan 1 & 2
• Thymosin Beta 4 (TB4)
• TB5
• GHK Copper
• Pentosan Polysulfate
• AOD9204
• P21
• M677
• Tesamorelin
• KPV
• MOTS-C
• SS 31

Resources:

Connect with Dr. Paulvin

https://doctorpaulvin.com/

Today’s show is a deep dive into exogenous ketones. You’ll learn about the latest advances and products, what the benefits are, and what to expect from the upcoming research in this exciting field. I’m joined by Frank LLosa, the CEO and founder of KetoneAid. He’s an expert on all things ketones, and I’m excited to have him on today’s show to help us learn more!

Show Highlights:

• What are exogenous ketones?
• Your body’s fuel source: glucose or ketones
• Why we should beware of the misinformation in the world about products related to ketones and ketosis
• How to understand ketone esters, BHB, and what they do for the body
• The top benefits of using a ketone product: recovery, mental cognition, and sleep
• How exogenous ketones should be taken (Too much of a good thing is NOT good!)
• What to expect from exogenous ketones in brain activity
• How following the keto diet differs from taking exogenous ketones
• What exogenous ketones can do for high-performance athletes and average athletes
• How to be an educated consumer in today’s ketone market
• Where the future is headed in the field of exogenous ketones
• An overview of products available at KetoneAid (including their upcoming ketogenic, gluten-free beer!)
• Where ketone science is headed for the future

Resources:

Connect with Dr. Paulvin

https://doctorpaulvin.com/

Connect with Frank and KetoneAid

www.ketoneaid.com, Instagram, Facebook, and YouTube

We are diving deep into some of today’s most popular scientific breakthroughs in the field of health optimization. My expert guest shares real-life applications from his wealth of knowledge and experience. Join us to learn more about feeling better, looking better, and adding years to your health span!

Dr. John Sottery is a Ph.D. scientist who believes that “aging normally” is a disaster. As a 63-year-old with young children, he is incredibly focused on maximizing his health and lifespan. His goal is to teach others how to outperform their chronological age through mitochondrial and cardiovascular health, and he focuses his research on ways to turn on the body’s genes that will drive protection and repair. After obtaining his doctorate in chemistry from Duke University, he led project development teams at Procter & Gamble before leaving to start several companies of his own. Through his work today, he attacks problems to understand them at a molecular level to maximize health span, slow down the damage, and accelerate repair in the body. 

Show Highlights:

• What is most important to know in optimizing mitochondrial health
• Why we need to understand what damages mitochondria, how to get rid of the damaged ones, and how to create new mitochondria from undamaged ones
• Dr. John’s #1 tip for mitochondrial health: Don’t eat within three hours of going to bed.
• How to push your mitochondria with ice baths, saunas, or HIIT workouts–so that your body knows how to recycle defective mitochondria
• How to understand the basics of intermittent fasting, autophagy, antioxidants, and free radicals
• Why broccoli sprouts are good for us–and other foods that turn up Nrf2
• How the body’s phase 2 toxification enzymes work to eliminate carcinogens
• Dr. John’s take on getting vital nutrients from food vs. relying on supplements
• How to get the most nutrition out of the broccoli you eat
• How fasting, exercise, Resveratrol, and spermidine help turn up autophagy
• Highlights of the overall benefits of spermidine, including recent research about preventing colon cancer and osteoporosis
• Sources and benefits of ergothioneine (an amino acid found primarily in mushrooms)
• Why copper can be the difference between mild cognitive impairment and full-blown Alzheimer’s (Eat your mushrooms!)
• Why YOUR body has its own recipe for optimal health
• Dr. John’s final thoughts about how excess fructose, alpha tocopherols, and omega-6 fats are harming people

Resources

Connect with Dr. Paulvin

https://doctorpaulvin.com/

Connect with Dr. John

www.johnsottery.com, Facebook, and YouTube

Mentioned in this episode: Dr. Guido Kroemer on YouTube, Nature Wants Us to Be Fat by Dr. Richard Johnson and Drop Acid by Dr. David Perlmutter