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In today’s episode, I’m doing a much-needed update on one of the most underrated peptides in the entire space: VIP (Vasoactive Intestinal Peptide). This is one of those “ancillary” peptides that people usually only associate with lungs or mold, but the deeper you go, the more you realize VIP is a master regulator that touches almost every major system in the body.

I walk you through what VIP actually is (a 28–amino acid peptide discovered in 1970), why it’s produced all over the body (brain, lungs, heart, gut, endocrine organs), and why it works so differently than peptides like BPC-157, TB-500, or the GLP-1s. We’ll cover the core mechanisms in a way that’s technical but practical: VPAC1/VPAC2 receptors, cAMP signaling, smooth muscle relaxation, glandular secretion, and immune modulation.

Then I zoom out into a broad “survey” of VIP’s real-world use cases: lung function and oxygenation, gut motility and stool quality, autoimmune regulation, brain fog, mood/anxiety, circadian rhythm, and even dysautonomia patterns like POTS and long COVID. I also break down dosing best practices for subcutaneous vs intranasal, what to expect the first time you use it (including the niacin-like flush), and how I personally think about cycling VIP long-term.

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The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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In today’s episode, I’m breaking down a peptide that doesn’t get nearly enough attention, but can be genuinely life-changing for the right person: Vesilute.

This is one of the Russian peptide bioregulators developed at the St. Petersburg Institute of Bioregulation and Gerontology, and in this episode I’m specifically focusing on the injectable bladder peptide, not the oral version. If you’ve heard me talk about Prostamax before, Vesilute is its natural counterpart on the bladder side — and when paired together, they form what I call a bladder–prostate axis strategy for comprehensive urinary health in men. For women, Vesilute stands on its own as a powerful option for overactive bladder, especially during peri- and post-menopause.

I walk through exactly how Vesilute works at a cellular level — how these tissue-specific peptides enter bladder cells, influence gene expression, and help restore a more youthful, functional state to the urothelium and detrusor muscle. We talk about why urgency, frequency, weak flow, nocturia, and even that awkward “can’t go when you need to” situation happen as we age, and how Vesilute may help normalize those patterns rather than just masking symptoms.

I also dig into the Russian clinical data, including placebo-controlled trials in men with BPH and women with overactive bladder, showing meaningful improvements in urinary flow, symptom scores, and quality of life — all with an excellent safety profile and virtually no systemic side effects. This is where AI translation has really opened the door to research that’s been siloed for years, and I share what I found most compelling.

From there, I outline my preferred injectable protocol: 1–2 mg daily for 60 days, run 2–3 times per year, why I prefer that over shorter high-dose protocols, and how to pair Vesilute with Prostamax in men for better overall results. I also talk through what people typically notice week by week, how long benefits tend to last after a cycle, and why even reducing nighttime urination from three trips to one can have massive downstream effects on sleep, energy, mood, metabolism, and overall longevity.

This isn’t a hype peptide. It’s not flashy. But if bladder issues, frequent urination, BPH, or overactive bladder are impacting your sleep or quality of life, this may be one of the most underrated and cost-effective peptides you can use. My goal with this episode is to give you the full context — the science, the data, the real-world experience — so you can decide if it makes sense for you.

As always, thank you for the support, for being here, and for helping me keep this information free and accessible. If you’ve used Vesilute, I’d love for you to share your experience in the comments so others can learn from it too.

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The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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In this episode, I dive deep into a topic that’s been coming up more and more over the last 12–18 months: anhedonia and motivational blunting in people using GLP-1 agonist peptides. While GLP-1s like semaglutide, tirzepatide, and retatrutide have been absolute game-changers for weight loss, metabolic health, and even addictive behaviors, there’s a smaller—but very real—subset of people who experience something unexpected: a reduced ability to feel pleasure.

Personally, I’ve never experienced this side effect. In fact, GLP-1s have done the opposite for me by giving me more mental clarity and freedom from compulsive behaviors. But enough people have reported feeling emotionally flat, unmotivated, or disconnected from things they used to enjoy that it deserves a serious, evidence-based conversation.

In this episode, I break down what anhedonia actually is, how it differs from depression, and why it can happen with GLP-1s from a neurochemical standpoint—specifically dopamine signaling and reward circuitry in the brain. We’ll look at the clinical data, real-world reports, differences between GLP-1 compounds, and why dose, speed of titration, weight loss, hormones, and lifestyle factors all matter.

Most importantly, I share practical strategies for mitigating these effects so you can still harness the benefits of GLP-1s without sacrificing joy, motivation, or quality of life.

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Timestamps:

00:14:36 – “What big trend in peptides do you see becoming popular?”

00:19:40 – “Using GLP-2 twice per week… how to switch to GLP-3 for maintenance?”

00:22:00 – “It’s hard to keep muscle mass on GLPs – what peptides help?”

00:23:36 – “Any peptides that stimulate hunger or appetite?” (Jay)

00:24:10 – “Did you experience anhedonia on RETA?”

00:31:00 – “IGF-1 LR3 stability – does it lose effectiveness after reconstitution?”

00:31:56 – “Does oral GLP (orforglipron) have benefits beyond appetite suppression?”

00:33:30 – “What is your New Year’s protocol / what are you experimenting with?”

00:36:59 – “Good starter protocol with SS-31, MOTS-C, BPC-157, Ipamorelin, CJC, RETA?”

00:39:46 – “Glutathione injections causing soreness – normal?”

00:40:00 – “How to reduce water retention on growth hormone peptides?”

00:41:30 – “Low iron in a 21-year-old, fatigue, and peptides for depression?”

00:43:24 – “Taste changes on RETA – is that common?”

00:44:16 – “Can GLPs cause hair thinning?”

00:44:34 – “Thoughts on Klotho?”

00:45:02 – “Why Ipamorelin over Tesamorelin for women?”

00:45:34 – “Peptide cheat sheet dosing – AM/PM split clarification?”

00:46:29 – “Will RETA ever be oral? (needle-averse)”

00:47:59 – “Best way to get Jardiance without Bitcoin?”

00:48:59 – “Any info on Stamakort-10?”

00:50:57 – “Can GLPs help reduce alcohol cravings?”

00:53:05 – “Can you talk more about MOTS-C?”

00:54:15 – “Does metformin deplete B-vitamins?”

00:55:14 – “Does topical GHK-Cu work for skin benefits vs injectable?”

00:57:39 – “Bioregulator capsules vs injectable effectiveness?”

01:03:26 – “Post-viral upper respiratory recovery – would VIP help?”

01:04:48 – “Best place to get testosterone for women?”

01:14:04 – “Insomnia on RETA – causes and fixes?”

01:21:25 – “Do you recommend topical estrogen?”

01:34:09 – “Growth hormone peptides after thyroid cancer – safe?”

01:37:14 – “Progesterone causes mood issues – alternatives?”

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The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Download The Bioregulator Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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Today’s episode is my updated deep dive on IGF-1 LR3, and I’m doing it for a very specific reason: this is a peptide I genuinely love using, but most people either don’t know it exists… or they only know it through the bodybuilding mythos that’s been floating around for years.

IGF-1 LR3 got popular in the research community because it was labeled as the “holy grail” that would supposedly turn you into a stage-winning bodybuilder overnight. I’m telling you right now — that’s not the use case, and if that’s the expectation, you’re going to be disappointed. What I am going to talk about is the real longevity optimization lane: strategic, disciplined, a few times per year — mostly around preserving and building muscle, improving body recomposition, and supporting healthspan as IGF-1 declines with age.

We’re going to break down what IGF-1 LR3 actually is (and how it’s different from other IGF options), the mechanisms that make it so interesting beyond “muscle building” — including some under-discussed mitochondrial and brain angles — and then we’ll talk practical use: timing, why I prefer post-workout, how to avoid the biggest mistake people make (hypoglycemia), and why this isn’t a “beginner peptide.”

I’ll also explain where IGF-1 LR3 fits in the bigger picture if you’re already doing TRT, GH peptides or HGH, and metabolic optimization. And as always — if you want the links, the resources, and the back catalog of my deleted YouTube content, make sure you’re on the email list. Check the description, and check out the Axion Collective — that’s my main mission in 2026: building the most ego-free, judgment-free place to learn this stuff with like-minded people.

Let’s get into it.

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Today’s episode is all about a peptide called Thymogen. Sometimes you’ll see it spelled Thymagen, but I’ve always preferred “Thymogen” because it just rolls off the tongue. Either way, we’re talking about a bioregulator peptide that works specifically on the immune system, and it’s one that’s been floating around research circles for a while… but I haven’t gone deep on it until now.

Most of you have heard me talk about Thymalin — and I love Thymalin. I’ve used it a lot, and in certain use cases I even like it more than Thymosin Alpha-1. But here’s the key: Thymalin is broad-spectrum. It’s like a full thymus “reset.” Thymogen is more targeted — especially for the “post-viral” use case, that lingering sickness, the recovery phase, or even as a proactive tool when colds and flus are making their rounds. And honestly, that’s exactly why this episode matters right now, because I’ve been dealing with a little head cold myself after travel and lack of sleep.

In this episode, I break down what Thymogen is (a synthetic dipeptide: L-glutamyl-L-tryptophan), why it’s interesting from a longevity perspective, and what we know about its safety history in Russia. Then we get into the mechanisms: T-cell maturation, immune surveillance, neutrophil function, and even some of the signaling pathways it appears to influence like ERK, mTOR-related proteins, STAT1, and chromatin remodeling. I also explain why I see Thymogen as more of an immune modulator than a blunt “stimulator,” which matters a lot if you’re dealing with inflammation or an overactive immune system.

We’ll talk practical benefits — fewer infections, better recovery, inflammation control, and why the animal data is intriguing when you look at lifespan and tumor incidence. Then I’ll give you my straightforward protocol: 1–2 mg per day for 30–60 days, usually once or twice per year as a tune-up… and also how I’d deploy it if you’re actively sick or dealing with something that just won’t clear.

Finally, I’ll compare Thymogen vs Thymalin, and I’ll explain how you can use them together: Thymalin as the foundation, Thymogen as the fine-tuning. And I’ll even touch on when I’d consider stacking them with Thymosin Alpha-1 if you’re trying to cover every base for immune protection.

Before we jump in — thank you. Seriously. As we wrap up 2025, I’ve been overwhelmed with gratitude for the messages from people telling me they’re getting real results. I don’t exist without you guys. Also make sure you’re on the email list (link in the description) so we can stay connected no matter what happens on social platforms. And if you want direct access to me, live calls, and real-time feedback on your protocols, check out the Axion Collective — it’s the community I’m putting everything into.

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In today’s episode, I’m breaking down one of the most common—and most misunderstood—questions I get about testosterone therapy: intramuscular (IM) injections versus subcutaneous (SubQ) injections.

Right out of the gate, I want to be clear about something—there is no single “right” answer here. There are different bodies, different lifestyles, different physiologies, and different goals. What I do have is experience, data, and a strong personal preference that I explain openly throughout this episode.

I walk through the actual pharmacokinetics and pharmacodynamics behind IM versus SubQ testosterone—how absorption differs, how peak-to-trough curves behave, how injection frequency changes everything, and why the conversation shifts entirely once you move into every-other-day or daily microdosing instead of once-weekly injections.

We also get into topics most people gloss over or oversimplify: estradiol conversion, hematocrit changes, mood and cognitive stability, libido and sexual function, injection site reactions, mast cell activation, carrier oils, body fat considerations, and why some people feel incredible on one method and awful on the other.

Importantly, this episode is not just for men. I spend time addressing testosterone therapy for women, dosing considerations, concentration issues, and why delivery method matters just as much—if not more—when female physiology is involved.

At the end of the day, my goal isn’t to convince you to inject the way I do. My goal is to give you enough context, data, and real-world nuance so you can make an informed decision, experiment intelligently, and work with your labs instead of against them.

As always, I’m incredibly grateful to be able to do this work and to have a community that actually wants to understand hormones at a deeper level. If you want to stay connected, the email list is where I share things I often can’t say—or haven’t filmed yet.

CORRECTION: SS-31 is a synthetic peptide, not an endogenous peptide. MOTS-c is an endougenous peptide.

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What you’re about to watch (or listen to) is a little different than my usual solo deep-dive, and I think you’re going to love it.

A couple months ago, Fountain Life reached out to me after seeing my work on peptides. They wanted help integrating peptides into their membership program, and in return they invited me to actually go through their diagnostics as a member so I could experience the process firsthand. I went to their Orlando, Florida facility and did what would normally take seven or eight different doctor visits and specialists… all in one place, in one morning.

The first part of this episode is a behind-the-scenes walkthrough of my Day 1 testing, including imaging and data collection that gives you a real baseline to work from. If you’re listening to audio-only, I highly recommend watching the video for that segment because it’s very visual. The second part is the main event: a long-form conversation with Fountain Life’s medical director and CEO, Dr. Bill Cap.

In the podcast, we go deep on the real history of peptides, why so much foundational work came out of places like Russia, and why the U.S. is only now starting to catch up. We talk about what’s hype, what’s timeless, and what actually moves the needle when it comes to longevity and performance. We also get into where peptides are headed next, because as we roll into 2026, the peptide landscape may look a little different than what people have gotten used to over the last few years.

We cover a ton of ground: GLP-1s as a legitimate longevity tool when used intelligently, growth hormone peptide strategies and why cycling matters, mitochondrial peptides like SS-31 and MOTS-c, and why “baseline first” is the missing piece for most people who jump into supplements, peptides, and biohacking without understanding what’s going on under the hood.

This isn’t a paid advertisement. I’m documenting what I’m going through, what my results show, and how I’m thinking about using peptides and other interventions based on real data instead of guesswork. If you’ve ever wanted to see what “precision prevention” actually looks like in the real world, this episode is a great place to start.

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Q&A on Peptides, Supplements, and Healing ProtocolsIn this episode, Hunter Williams addresses a variety of audience questions on peptides, amino acids, supplements, and health-related protocols. Hunter talks about the best dosages for peptides like 5-amino, Melanotan, and BPC-157, as well as their applications for muscle gain, fat loss, and healing from injuries. He delves into peptide protocols for conditions such as multiple sclerosis, chronic pain, and seasonal allergies. Hunter offers insights into using essential amino acids and testosterone, discusses the effects of GLP-1s, and touches on flying with peptides, bioavailability, and potential side effects. This episode serves as a comprehensive guide to optimizing health and performance, especially through the lens of peptide and supplement use.00:00 Introduction and Q&A Overview

02:25 Dosing for 5-Amino and Injection Tips

04:02 Flying with Peptides

05:01 Essential Amino Acids and Their Benefits

05:57 Peptide Protocols for Multiple Sclerosis

06:28 B7-33 Peptide Insights

07:24 Testosterone Dosing Before a Date

08:30 Peptide Purity and TFA Concerns

09:19 P21 Peptide for Brain Health

10:06 Metformin and SGLT2 Inhibitors

11:04 Injection Site Issues and Solutions

12:17 VIP Peptide for Erectile Dysfunction

13:28 Stacks for Appetite Control and Muscle Gain

18:42 HPA Axis and Testosterone Support

22:19 Addressing Erectile Function and Blood Pressure

22:27 Peptide Stack for Seasonal Allergies

22:50 Metformin and Blood Sugar Levels

23:40 Growth Hormone Peptides and Pre-Workout Tips

24:52 Cloudy Peptides: Causes and Solutions

26:11 Alcohol and Peptide Interaction

27:47 Melanotan and Vacation Tanning Tips

28:41 Peptides for Bulging Discs and Pain Management

29:38 Timing for Growth Hormone Peptides

30:04 Peptide Recommendations for Energy, Weight Loss, and Muscle Gain

30:41 Peptide Use in Older Adults

31:20 Combining Peptides for Appetite Suppression

32:05 Creatine Benefits for Women in Their Twenties

32:11 Comparing Peptides for Longevity and Fat Burning

33:12 Chronic Pain Management with Peptides

33:41 Addressing Fatigue with Peptides

34:33 Switching Peptides for Better Results

35:17 Peptides and Skin Tone

35:51 Exploring New Peptides for Acne

36:26 NAD+ and Peptide Stacks

37:01 Hypothyroidism and Testosterone Replacement Therapy

37:22 Modafinil for Focus and Neurogenesis

38:00 Peptides for Eye Floaters

38:14 Prostate Health and Peptides

38:36 Critiquing Personal Regimens

38:56 Peptides and Tumor Growth

39:36 Comparing HGH and HGH Fragments

40:21 Testosterone Dosing for Men

41:37 Peptides for Post-Surgery Recovery

41:58 Final Thoughts and Audience Appreciation

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In today’s episode, I’m diving into a mitochondrial peptide that almost nobody is talking about yet, but that I believe is going to become a major player in longevity and brain health over the next decade: Humanin.

Most people are familiar with mitochondrial peptides like SS-31 or MOTS-c. Humanin is different. It’s an endogenous mitochondrial-derived peptide, meaning your body actually makes it naturally, and it plays a critical role in protecting cells, especially under conditions of stress and aging. What really caught my attention with Humanin is that it appears to sit at the intersection of mitochondrial health, neuroprotection, and longevity signaling.

In this episode, I walk through what Humanin is, how it was discovered, and why researchers originally became interested in it, particularly in the context of Alzheimer’s disease and neurodegeneration. We’ll talk about how Humanin functions as a cellular “distress signal” from the mitochondria, how it blocks apoptosis, protects mitochondrial membranes, and helps cells survive oxidative and metabolic stress.

I also break down how Humanin differs from other mitochondrial peptides like MOTS-c and SS-31, and why I see it as a uniquely powerful option for brain health and cognitive longevity. We’ll look at animal data, observational human data, and fascinating correlations showing that centenarians and their offspring tend to have significantly higher endogenous Humanin levels.

From there, I cover potential benefits across brain health, metabolism, cardiovascular function, and lifespan, along with how I personally think about cycling Humanin alongside other mitochondrial peptides throughout the year. Finally, I share my practical thoughts on dosing, cycling strategies, and who I think Humanin is best suited for, especially as we get more focused on preserving cognitive function as we age.

If you’re interested in mitochondrial health, longevity, brain optimization, or peptide replacement strategies, this episode will give you a solid foundation on why Humanin deserves a spot on your radar.