CORRECTION: SS-31 is a synthetic peptide, not an endogenous peptide. MOTS-c is an endougenous peptide.

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What you’re about to watch (or listen to) is a little different than my usual solo deep-dive, and I think you’re going to love it.

A couple months ago, Fountain Life reached out to me after seeing my work on peptides. They wanted help integrating peptides into their membership program, and in return they invited me to actually go through their diagnostics as a member so I could experience the process firsthand. I went to their Orlando, Florida facility and did what would normally take seven or eight different doctor visits and specialists… all in one place, in one morning.

The first part of this episode is a behind-the-scenes walkthrough of my Day 1 testing, including imaging and data collection that gives you a real baseline to work from. If you’re listening to audio-only, I highly recommend watching the video for that segment because it’s very visual. The second part is the main event: a long-form conversation with Fountain Life’s medical director and CEO, Dr. Bill Cap.

In the podcast, we go deep on the real history of peptides, why so much foundational work came out of places like Russia, and why the U.S. is only now starting to catch up. We talk about what’s hype, what’s timeless, and what actually moves the needle when it comes to longevity and performance. We also get into where peptides are headed next, because as we roll into 2026, the peptide landscape may look a little different than what people have gotten used to over the last few years.

We cover a ton of ground: GLP-1s as a legitimate longevity tool when used intelligently, growth hormone peptide strategies and why cycling matters, mitochondrial peptides like SS-31 and MOTS-c, and why “baseline first” is the missing piece for most people who jump into supplements, peptides, and biohacking without understanding what’s going on under the hood.

This isn’t a paid advertisement. I’m documenting what I’m going through, what my results show, and how I’m thinking about using peptides and other interventions based on real data instead of guesswork. If you’ve ever wanted to see what “precision prevention” actually looks like in the real world, this episode is a great place to start.

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Q&A on Peptides, Supplements, and Healing ProtocolsIn this episode, Hunter Williams addresses a variety of audience questions on peptides, amino acids, supplements, and health-related protocols. Hunter talks about the best dosages for peptides like 5-amino, Melanotan, and BPC-157, as well as their applications for muscle gain, fat loss, and healing from injuries. He delves into peptide protocols for conditions such as multiple sclerosis, chronic pain, and seasonal allergies. Hunter offers insights into using essential amino acids and testosterone, discusses the effects of GLP-1s, and touches on flying with peptides, bioavailability, and potential side effects. This episode serves as a comprehensive guide to optimizing health and performance, especially through the lens of peptide and supplement use.00:00 Introduction and Q&A Overview

02:25 Dosing for 5-Amino and Injection Tips

04:02 Flying with Peptides

05:01 Essential Amino Acids and Their Benefits

05:57 Peptide Protocols for Multiple Sclerosis

06:28 B7-33 Peptide Insights

07:24 Testosterone Dosing Before a Date

08:30 Peptide Purity and TFA Concerns

09:19 P21 Peptide for Brain Health

10:06 Metformin and SGLT2 Inhibitors

11:04 Injection Site Issues and Solutions

12:17 VIP Peptide for Erectile Dysfunction

13:28 Stacks for Appetite Control and Muscle Gain

18:42 HPA Axis and Testosterone Support

22:19 Addressing Erectile Function and Blood Pressure

22:27 Peptide Stack for Seasonal Allergies

22:50 Metformin and Blood Sugar Levels

23:40 Growth Hormone Peptides and Pre-Workout Tips

24:52 Cloudy Peptides: Causes and Solutions

26:11 Alcohol and Peptide Interaction

27:47 Melanotan and Vacation Tanning Tips

28:41 Peptides for Bulging Discs and Pain Management

29:38 Timing for Growth Hormone Peptides

30:04 Peptide Recommendations for Energy, Weight Loss, and Muscle Gain

30:41 Peptide Use in Older Adults

31:20 Combining Peptides for Appetite Suppression

32:05 Creatine Benefits for Women in Their Twenties

32:11 Comparing Peptides for Longevity and Fat Burning

33:12 Chronic Pain Management with Peptides

33:41 Addressing Fatigue with Peptides

34:33 Switching Peptides for Better Results

35:17 Peptides and Skin Tone

35:51 Exploring New Peptides for Acne

36:26 NAD+ and Peptide Stacks

37:01 Hypothyroidism and Testosterone Replacement Therapy

37:22 Modafinil for Focus and Neurogenesis

38:00 Peptides for Eye Floaters

38:14 Prostate Health and Peptides

38:36 Critiquing Personal Regimens

38:56 Peptides and Tumor Growth

39:36 Comparing HGH and HGH Fragments

40:21 Testosterone Dosing for Men

41:37 Peptides for Post-Surgery Recovery

41:58 Final Thoughts and Audience Appreciation

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In today’s episode, I’m diving into a mitochondrial peptide that almost nobody is talking about yet, but that I believe is going to become a major player in longevity and brain health over the next decade: Humanin.

Most people are familiar with mitochondrial peptides like SS-31 or MOTS-c. Humanin is different. It’s an endogenous mitochondrial-derived peptide, meaning your body actually makes it naturally, and it plays a critical role in protecting cells, especially under conditions of stress and aging. What really caught my attention with Humanin is that it appears to sit at the intersection of mitochondrial health, neuroprotection, and longevity signaling.

In this episode, I walk through what Humanin is, how it was discovered, and why researchers originally became interested in it, particularly in the context of Alzheimer’s disease and neurodegeneration. We’ll talk about how Humanin functions as a cellular “distress signal” from the mitochondria, how it blocks apoptosis, protects mitochondrial membranes, and helps cells survive oxidative and metabolic stress.

I also break down how Humanin differs from other mitochondrial peptides like MOTS-c and SS-31, and why I see it as a uniquely powerful option for brain health and cognitive longevity. We’ll look at animal data, observational human data, and fascinating correlations showing that centenarians and their offspring tend to have significantly higher endogenous Humanin levels.

From there, I cover potential benefits across brain health, metabolism, cardiovascular function, and lifespan, along with how I personally think about cycling Humanin alongside other mitochondrial peptides throughout the year. Finally, I share my practical thoughts on dosing, cycling strategies, and who I think Humanin is best suited for, especially as we get more focused on preserving cognitive function as we age.

If you’re interested in mitochondrial health, longevity, brain optimization, or peptide replacement strategies, this episode will give you a solid foundation on why Humanin deserves a spot on your radar.

If you decide to pick one up, you can get $500 off your purchase by using the code HUNTERW at checkout on the Bimini site.

You can check out the different models here. I have the Nanojet Eco (Eco for home, Pro/All-In for facilities).

👉 Bimini products page: https://biminihydrotherapy.com/products/ 

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In this episode, I’m breaking down what has quietly become the number one recovery and biohacking device in my entire house — the Bimini NanoJet oxygen therapy system.

This is not a paid advertisement. I’m not big on filling my house with random gadgets, and I tend to be pretty skeptical of most “biohacking toys.” But after almost a year of using the Bimini device three to four times per week, I can honestly say it’s right up there with medical-grade red light therapy for the impact it’s had on my recovery, sleep, and overall performance.

I start by sharing the story of how I found Bimini at A4M in Las Vegas, saw Kyrie Irving on their booth, and got curious enough to dig into what the tech actually does. From there, I explain in simple language how the NanoJet works: it sits next to your bathtub, recirculates the water, and saturates it with ultra-fine oxygen nanobubbles that are small enough to penetrate your skin and deliver oxygen directly into your tissues — without a mask, chamber, or pressure changes.

Then we dive into my real-world results:

• How I started hitting HRV scores in the 90s and over 100 on my Oura for the first time.

• What happened to my deep sleep and sleep scores when I used it at night.

• The massive difference I feel in soreness and recovery after heavy training days.

• How it’s helped Taylor with plantar fasciitis and why it’s become part of her lower-body recovery.

• And the surprising changes in my skin health, especially on my back, after years of struggling with acne.

From there, I connect the dots with the published data Bimini has commissioned and the broader science on oxygen nanobubbles — including animal studies on wound healing, transdermal delivery studies, and what university sports programs are seeing in their athletes. I also compare NanoJet therapy to hyperbaric oxygen: what’s similar, what’s different, and why, for day-to-day use at home, I think this is a more practical option for most people.

If you’re already dialed in with your training, peptides, and nutrition and you’re looking for that next-level recovery edge, this episode will give you a deep dive into a technology that almost nobody is talking about yet — but probably will be in the next few years.

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In this episode, I’m revisiting one of the most underrated peptides in the entire toolbox: DSIP – Delta Sleep Inducing Peptide.

About a year and a half ago I did a deep dive on DSIP and mostly talked about it as a “sleep peptide.” Since then, I’ve spent a lot more time digging into the literature and experimenting with different dosing protocols myself – and what I’ve found is that DSIP is actually much more of a circadian rhythm peptide than a simple knock-you-out sleep aid.

I walk you through the origin story of DSIP, how Swiss researchers first isolated this nine–amino acid peptide from rabbits in deep delta sleep back in the 1970s, and why it’s so fascinating that it shows up in human brain, plasma, and even breast milk. We talk about the wild fact that DSIP can cross the blood–brain barrier, and why that makes nasal spray formulations surprisingly effective in real-world use.

From there, we get into mechanisms: DSIP’s ability to lower ACTH and cortisol, act as a “stress-limiting” factor, nudge growth hormone a bit, modulate pain pathways, and influence neurotransmitters like Substance P. I break down why I see it as a multi-system modulator that gently rebalances the body’s own sleep circuitry instead of sedating you like Ambien.

We cover the human data from the 1980s – the insomnia trials where DSIP normalized sleep architecture, the European study using DSIP in alcohol and opiate withdrawal with surprisingly high success rates, and a small pilot in chronic pain and tinnitus where most patients had meaningful relief.

Then I share how I actually use it: my preferred subcutaneous dosing range of 100–500 mcg, why I think 2–3 hours before bed on an empty-ish stomach works best, and how I’m planning to use DSIP more aggressively for jet lag and circadian realignment when I travel. I also talk about my wife’s experience (she loves DSIP) versus mine (I don’t struggle with sleep, but I still see it as a staple tool).

Finally, I touch on safety, the immunogenicity caveat, and why DSIP probably isn’t a top-5 peptide—but is absolutely one I’ll always keep in the house.

If you want more conversations like this and direct Q&A access, make sure you’re on my email list and check out The Axion Collective, my private community for peptide researchers and optimization nerds.

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In this episode, I’m diving into something that I honestly didn’t realize was as big of an issue as it is until it hit my own family: lung health. Earlier this year my father-in-law was hospitalized with what the doctors loosely labeled as COPD—trouble breathing, fluid in the lungs, inflammation, all the scary stuff that makes you realize how fragile life can be. When he finally got home from the hospital, I put him on a very specific peptide stack designed for deep respiratory repair, and the results were nothing short of incredible.

That experience inspired today’s episode. I walk you through the exact peptide stack we used to regenerate lung tissue, modulate inflammation, and get him back on his feet WAY faster than the standard prognosis. We’re talking about Bronchogen, Chonluten, VIP (Vasoactive Intestinal Peptide), TB-500, and GHK-Cu—each of them working on different mechanistic pathways ranging from DNA-level gene expression to immune modulation to fibrosis prevention.

You’ll hear the science, the clinical evidence, the dosing, and—maybe most importantly—why this stack worked so well for a real human being in a real crisis. And yes, even if you’re “healthy,” these peptides have profound regenerative and anti-aging properties for the lungs that make them worth understanding.

Chronic respiratory disease is the third leading cause of death worldwide. Over 454 million people suffer from lung-related conditions. And when you see those numbers—and then see firsthand how quickly lung tissue can repair with the right tools—you start to understand why peptide-based regenerative medicine is the future.

Whether you’re dealing with COPD, bronchitis, long-haul viral issues, inflammation, fibrosis, smoker’s lungs, or you simply want to bulletproof your respiratory system as you age… this episode is for you.

As always, make sure you’re on my email list so you stay connected no matter what platform bans me next. That’s where all my best content lives, including updates when I release episodes like this one.

I’m so grateful for each and every one of you who listens, comments, uses my codes, and shares this work. This truly is a dream come true, and your support allows me to bring the highest-quality peptide and hormone optimization content to the world.

Strap in—and let’s get into the peptide stack for lung health.

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In today’s episode, I’m diving deep into what might be one of the most overlooked pillars of longevity and metabolic optimization: liver health. Over the last few months I’ve been creating peptide stacks for specific organs and systems, and this one might be the most impactful yet.

Most people never think about their liver unless something goes really wrong. But here’s the wild thing: 30% of the global population now has NAFLD—non-alcoholic fatty liver disease. Nearly a billion people worldwide. Kids, teenagers, adults, high performers, people who “eat healthy”—no one’s immune to the toxic environment and metabolic pressure our livers are facing today.

So in this episode, I walk you step-by-step through the 12-week peptide protocol I’ve built for rejuvenating liver function, reducing liver fat, lowering inflammation, reversing fibrosis, and supporting long-term metabolic health—even if you don’t have diagnosed liver disease.

We break down each peptide, why it works, the mechanisms involved, and the actual data showing how dramatic these interventions can be. Some of them you’ve heard me talk about before. Others might surprise you with how profoundly they interact with liver tissue at the cellular and mitochondrial level.

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In today’s episode I’m diving into one of the most important studies we’ve ever seen on GLP-1s — and honestly, one of the most important in metabolic medicine in the last decade. A brand-new analysis just dropped on over 86,000 patients, tracked for up to 10 years, looking at the relationship between GLP-1 agonists and cancer risk. The numbers are staggering. We’re talking 17 percent lower overall cancer risk, 25 percent lower endometrial cancer, 47 percent lower ovarian cancer, and even a 31 percent reduction in brain tumors in people using GLP-1 medications.

This episode is something I’ve wanted to make for a long time. It’s rare that a single study forces you to zoom out and rethink the entire future of chronic disease, but this one does. I walk you through the data, the methodology, why the findings matter, and why this aligns with what I see every day in real-world metabolic optimization work. You’ll hear my perspective on correlation versus causation, how obesity mechanistically drives cancer, and why weight-loss drugs like GLP-1s might play a far bigger role in prevention and longevity than anyone expected.

This isn’t fear-based content. It’s the opposite. It’s hope. It’s the beginning of a shift away from reactionary medicine and toward upstream prevention. Whether you love GLP-1s, hate them, or are just curious, this episode is the clearest look yet at where the evidence is pointing. And as always, I finish with my reflections on why I’m so grateful to get to do this work and share these ideas with you.

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In this episode, I tackle one of the most persistent myths in the testosterone world. We are talking about estrogen – and why it is not the enemy for men on testosterone therapy.

I was inspired to record this after hearing that the FDA removed the black box warning from estrogen therapy for women. That got me thinking about how, in the men’s world, estrogen has been turned into this evil hormone that must be crushed at all costs. For a lot of guys, the moment they get prescribed testosterone, they’re automatically handed an aromatase inhibitor with zero thought or nuance. I think that’s a huge mistake.

In this conversation, I walk through why routine estrogen suppression is almost never necessary for the average man on TRT and how that “block estrogen at all costs” mindset came straight out of bodybuilding folklore and bro science. I break down the clinical data showing that low estrogen in men leads to more body fat, worse bone density, lower libido, more mood issues, and worse cardiovascular health – the exact problems TRT is supposed to fix.

We get into how estradiol supports bone mineral density, fat metabolism, sexual function, brain health, and endothelial function. I also share some of my own labs and experience, plus why chasing “perfect” lab ranges while ignoring symptoms leads so many men into trouble. High-normal estrogen alongside high-normal testosterone is not only normal, it is often protective.

Finally, I lay out a better framework: fix insulin resistance, improve lifestyle, let the body aromatize naturally, and reserve aromatase inhibitors as a true last resort. If you’re on TRT, thinking about starting, or have been scared into believing estrogen is out to ruin your life, this episode will give you a completely different lens to see your hormones through.

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In today’s episode I dive deep into a topic that almost nobody talks about even though it affects tens of millions of people every single year. We’re breaking down the full peptide stack for kidney health and renal longevity. When I first got into biohacking I didn’t think much about kidneys at all. I assumed they just silently did their thing in the background. But over the years, as I started working with more people and publishing more content, I realized how common kidney dysfunction is and how quickly it can go downhill if you don’t catch it early. That’s when I went down the rabbit hole of what actually causes kidney decline and what we can do to strengthen and protect renal function long before a diagnosis ever shows up.

Inside this episode I walk through the most important vulnerabilities the kidneys face as we age. These are things like oxidative stress, mitochondrial breakdown, metabolic strain, hypertension, hyperglycemia, inflammation, structural damage to the filtration barrier, and even vascular deterioration. Most people don’t realize the kidneys use up to ten percent of the body’s entire oxygen supply which makes them extremely sensitive to damage. I explain exactly how these vulnerabilities accumulate over time and why proactive support is just as important for someone who is “normal” as it is for someone with early-stage CKD.

From there I walk you step-by-step through the five-peptide kidney restoration protocol I put together. This stack includes SS-31, Jardiance, glutathione, ARA-290, and MOTS-C. I explain what each one does, why it matters, the exact dose and frequency I recommend, and what role it plays in repairing, protecting, and unloading the kidneys. I talk about mitochondrial protection, reducing hyperfiltration, lowering mechanical stress, restoring antioxidant defenses, repairing microvasculature, activating AMPK, improving metabolic flexibility, and reversing early fibrosis. This isn’t theory. I’ve watched these compounds move the needle for real people in the real world.

I also walk you through the synergy of the full stack. When these agents work together, they offload the metabolic burden on the kidneys while strengthening the cellular machinery that has to keep you alive for decades. I compare it to walking around with a sixty-pound weight vest: eventually that load catches up. This protocol systematically removes that load while improving the kidney’s structural resilience at the same time.

At the end I cover what to monitor on bloodwork, how to cycle the protocol, what can be used long-term, and the signs you want to get in front of before they spiral into full kidney disease. Whether you have diagnosed kidney problems or you simply want to protect your renal function as part of your longevity plan, this episode gives you a blueprint you can use immediately.

As always, make sure you are on my email list so you never miss my content even if platforms delete me. Thank you for being here and letting me bring this information to you. I have so much gratitude for everyone supporting the channel. Enjoy the episode and share it with anyone who needs it.