We covered:

Fasted training

Protein timing

and many more fitness topics!

Hear Dr. Lauren Colenso-Semple and Dr. Stacy Sims discuss outcomes versus mechanisms and much more

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Takeaways

• The podcast features Dr. Grant Tinsley, a body composition expert.
• The discussion revolves around a case series on body composition effects.
• GLP-1 receptor agonists are a focus of the research.
• The importance of resistance training in weight loss is emphasized.
• Patient case studies provide insights into individual experiences.
• The first patient lost a significant amount of fat mass while preserving lean mass.
• The second patient achieved remarkable body composition changes in a short time.
• The third patient showed positive changes over a longer duration.
• The need for more randomized trials is highlighted.
• The conversation underscores the role of exercise and nutrition in weight management.
  
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Takeaways

Direct-to-consumer lab testing is on the rise, with significant marketing efforts behind it.

Many patients feel brushed off by traditional healthcare providers, leading them to seek alternative testing options.

Communication between patients and healthcare providers is often inadequate, contributing to misunderstandings about health.

Over-testing can lead to unnecessary anxiety and misinterpretation of results.

Fitness influencers often promote lab testing without proper medical training, which can be harmful.

There is a need for ethical practices in lab testing and patient care.

Patients should be cautious of companies that upsell supplements based on lab results.

The healthcare system often fails to provide adequate time for patient concerns to be addressed.

Understanding lab results requires skilled interpretation, which is often lacking in direct-to-consumer models.

A collaborative approach among healthcare professionals is necessary to improve patient outcomes.

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In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the recent changes in obesity medication coverage, particularly focusing on the CVS Caremark decision to drop ZEPBound from their formulary in favor of Wegovi. They explore the implications of this decision for patients and providers, the role of pharmacy benefit managers (PBMs) in healthcare, and the ongoing advocacy efforts to ensure access to effective obesity treatments. The conversation highlights the complexities of insurance coverage, the need for patient-centered care, and the importance of making medications more affordable.

- The recent changes in obesity medication coverage have raised concerns among providers and patients.

- CVS Caremark's decision to drop ZEPBound has sparked a petition advocating for better access to medications.

- Pharmacy Benefit Managers (PBMs) play a significant role in determining medication coverage and costs.

- There is a need for more nuanced insurance policies that consider patient needs and clinical severity.

- Advocacy efforts are crucial in reversing negative trends in medication coverage.

- Patients often face challenges with prior authorization processes when switching medications.

- The cost of obesity medications is a significant barrier to access for many patients.

- Insurance companies are increasingly dropping coverage for anti-obesity medications, impacting patient care.

- The conversation emphasizes the importance of patient-centered care in obesity treatment.

- There is a call for making obesity medications more affordable and accessible to patients.

https://www.change.org/p/stop-cvs-caremark-s-zepbound-ban-restore-coverage-of-the-superior-obesity-medication

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In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the Surpass CVOT trial, which evaluates the cardiovascular outcomes of Monjaro compared to Dulaglutide (Trulicity). They delve into the significance of the trial, the implications of the results, and the potential benefits of Monjaro for patients with type 2 diabetes and cardiovascular risks. The conversation highlights the importance of understanding cardiovascular outcome trials and the evolving landscape of diabetes medications.

Takeaways: 

The Surpass CVOT trial compares Mounjaro to Dulaglutide.

Dulaglutide has shown cardiovascular benefits in previous trials.

The trial results indicate Monjaro is at least not inferior to Dulaglutide.

There is a trend towards better cardiovascular outcomes with Mounjaro.

Weight loss and glycemic control are significant benefits of Mounjaro.

The trial did not include a placebo, but used a putative analysis.

The results are reassuring for patients at high cardiovascular risk.

The conversation emphasizes the importance of comprehensive treatment for metabolic diseases.

The hosts express enthusiasm for the potential of Mounjaro.

Future discussions will delve deeper into the trial's findings.

How the STEP-UP trial came to life,  and what made the 7.2mg dose possible

What the data actually says about weight loss and side effects at higher doses

Why trial design, pharmacokinetics, and estimands matter more than you think

What’s coming next in obesity meds: duals, triples, and even antagonists

The real talk on intermittent fasting, access issues, and preaching vs. science

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Takeaways

• The study examines the overlap between clinical and anthropometric obesity.
• Anthropometric measures include waist circumference, waist-to-hip ratio, and BMI.
• Challenges exist in applying the Lancet Commission's definitions in clinical practice.
• Metabolically healthy obesity is a debated topic in obesity research.
• The study highlights the importance of data from the All of Us Research Program.
• There is a significant prevalence of preclinical obesity in individuals with normal BMI.
• The classification of obesity may need to shift focus towards overweight individuals.
• The study's findings suggest a need for more nuanced definitions of obesity-related diseases.
• Future research will explore the transition from preclinical to clinical obesity.
• The conversation emphasizes the importance of real-world data in understanding obesity.

Click here to see the study

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Learn what age-related macular degeneration (AMD) is

What causes AMD

The types of AMD

The update on NAION - listen to last year's podcast all about it

Why we aren't too concerned

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Click to read the JAMA AMD article

Click to read the Ophthalmology journal AMD article

• Menopausal hormonal therapy should not be a blanket recommendation for everyone going through menopause
• Weight management in women is influenced by hormonal changes throughout life stages.
• Retrospective analyses can provide insights but have limitations.
• The wellness industry often oversimplifies complex medical issues.
• Hormonal replacement therapy may have subtle benefits for weight management.
• Confounding factors like SSRIs can complicate weight loss efforts.
• A holistic approach is essential for managing women's health during menopause.
• Education and awareness are crucial for women navigating menopause.
• Future research should focus on randomized controlled trials for better clarity.
• Understanding individual patient experiences is key to effective treatment.

Click here to see her study

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• Dr. Grant Tinsley joins the discussion as the body composition expert.
• Myostatin is a key regulator of muscle growth.
• Wendy Whippete the most jacked muscled up dog
• The concern of GLP-1 receptor agonists and muscle mass loss.
• Overview of Courage trial looking at semaglutide and trevogrumab and lean mass loss
• Upcoming Believe trial coming out (bimagrumab and semaglutide)
• Exercise remains crucial for muscle health and function.
• MRI data from SURPASS MRI provides new insights into muscle volume changes.
• The combination of medications may have varying effects on muscle mass.
• Caution is advised regarding the long-term effects of new drugs.
• Clinical benefits of medications often outweigh concerns about muscle loss.
• Future research will explore the synergy between exercise and medication.

Other docs who lift podcasts with Dr. Grant:

Tirzepatide muscle loss

Lean mass loss and GLP-1 meds