EP. 207: A new study on tirzepatide just dropped, and some obesity experts claim it confirms that the drug works only by reducing calories. After reading the full paper myself, I’ve got a different take. In this episode, I unpack what the study actually shows—like how tirzepatide increases fat oxidation without impacting metabolic adaptation—and why the “calories in, calories out” story doesn’t tell the whole truth. There’s more going on here, and you deserve the full picture.
Topics Covered:
Does tirzepatide help with metabolic health beyond calorie restriction leading to weight loss?How does it affect metabolic adaptation in people with obesity?Can it boost fat oxidation?Is the “calories in, calories out” model outdated for GLP-1s?What does this mean for long-term metabolic health?Qualia | Go to qualialife.com/DRTYNA for up to 50% off your purchase and use code DRTYNA for an additional 15%
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On This Episode We Cover:
00:00:00 – Introduction 00:02:44 – Obesity study on GLP1s and weight loss00:04:21 – Calories in vs. calories out00:05:44 – Resting metabolic rate00:09:25 – Metabolic adaptation during dieting00:12:11 – Tirzepatide dosing in clinical studies00:15:49 – Maintaining weight loss00:18:15 – GLP1s & increased fat oxidation00:19:14 – GLP1 microdosing myths00:26:06 – Metabolic rate drops vs. metabolic improvements00:29:51 – Lessons from the Biggest Loser study00:34:20 – Study Comparation00:35:25 – Weight loss, inflammation, and aging00:36:35 – Health autonomy 00:40:23 – Caloric restriction and the CALERIE studyTirzepatide Did Not Impact Metabolic Adaptation In People With Obesity, But Increased Fat OxidationPersistent Metabolic Adaptation 6 Years After The Biggest Loser CompetitionComprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE)GLP-1s Done Right UniversityDr. Tyna’s Strength CornerMetabolic Revamp Toolkit + MasterclassGLP1s Uncovered (Free Class)EP. 202 | The Fight for Affordable GLP1s & the Truth About Big Pharma | Dave Knapp
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