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📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
Today, I’m joined by Dr. Henry Mahncke, an innovative neuroscientist and the CEO of BrainHQ, who has dedicated over two decades to uncovering the powerful ways targeted training can help the brain process information faster and more efficiently. In our conversation, Dr. Mahncke shares his deeply personal motivation behind this work, recalling early experiences with his grandfather’s cognitive decline and how witnessing that loss inspired a lifelong mission to challenge outdated beliefs about the aging brain.
Visit BrainHQ.com/nat, and register for free with no credit card and receive one exercise per day, plus access to the BrainHQ brain-health blog.
Episode Timestamps:
The brain is not a fixed organ ... 00:00:00
Personal story: family and early memories of dementia ... 00:06:06
Origins of the myth that adult brains can’t change ... 00:08:30
Breakthrough research on neuroplasticity at UCSF ... 00:09:29
How processing speed underpins healthy cognitive function ... 00:16:37
Noisy, slow processing as a hallmark of aging brains ... 00:18:14
Speed training to synchronize and strengthen neural networks ... 00:19:32
Brain training as underlying “strength training” for cognition ... 00:20:40
Problems with current dementia research funding priorities ... 00:21:33
ACTIVE study: speed training reduces Alzheimer’s risk ... 00:24:46
Everyday, real-world benefits of brain training ... 00:28:04
Why brain training isn’t just crosswords and games ... 00:30:00
Neurochemistry of attention, reward, and adaptive challenge ... 00:31:16
Scientific rigor and industry skepticism ... 00:56:53
Expanding use: from seniors to athletes and special forces ... 01:00:12
Personal evolution in thinking about brain health ... 01:03:29
Brain training as an essential pillar for longevity ... 01:06:42
Learn more from Dr. Henry Mahncke below:
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Dr. Bill Lawrence Episode
Today, I'm joined by Michael Feldstein, founder of Jasper and co-founder of Kindling Academy, who has spent years sounding the alarm about the hidden dangers lurking in our indoor air. Michael has a unique ability to connect the dots between our everyday exposures—to things like synthetic fragrances, mold, and poor air quality—and our long-term health, performance, and even the well-being of our children.
Go to http://Jaspr.co/nat and use code NAT for the next two weeks for $350 dollars off!
Learn more from Michael Feldstein below:
Episode Timestamps:
Welcome, guest intro, and focus on reducing environmental toxins ... 00:00:00
Rising awareness of indoor air and fragrance toxicity ... 00:06:07
Synthetic fragrance compared to secondhand smoke ... 00:10:18
Labeling, hidden chemicals, and home fragrance exposures ... 00:14:06
Market trends: Americans spend more to pollute air than clean it ... 00:17:19
Cumulative toxic exposures and easy home interventions ... 00:23:23
Steps for better sleep and air quality without big spending ... 00:25:14
Air quality often ignored in wellness and medicine ... 00:29:31
Selecting monitors and purifiers that actually work ... 00:40:54
Kindling Academy: principles of a healthier school ... 00:45:57
Air quality, absenteeism, and school performance ... 00:51:01
Empowering children through environment and agency ... 01:00:00
Balanced prevention vs. fear in wellness ... 01:03:00
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Dr. Bill Lawrence Episode
📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
This week, I’m bringing you a special episode—a quarterly recap packed with some of the most fascinating conversations I’ve had recently on the future of health and longevity. From cutting-edge personalized skincare and breakthroughs in genetic responses to GLP-1 medications, to what you can really do about microplastics in your body, these are moments that genuinely excited me about where we’re headed.
Listen to the FULL episodes Mentioned:
Episode Timestamps:
Welcome and episode recap intro ... 00:00:00
Dr. Teo Soleymani: future of personalized skincare ... 00:05:12
Personalized genomics in dermatology and oncology ... 00:06:53
Emerging stem cell and anti-aging skin treatments ... 00:07:27
Precision dermatology and personalized approaches ... 00:09:37
Dr. Nora Abdul-Hussein: genetic variation in GLP-1 response ... 00:10:13
GLP-1 receptor gene and weight loss/nausea findings ... 00:11:19
Dosing implications and setting expectations for GLP-1s ... 00:13:14
Combining genetic and clinical factors in personalized care ... 00:15:44
Avoiding genetic determinism in medical language ... 00:17:03
Microplastics: widespread exposure and reducing risks ... 00:19:33
Emotional impact and hope for change in food systems ... 00:21:43
Bryce Applebaum: distinction between vision and eyesight ... 00:25:29
Preventing and reversing age-related vision decline ... 00:26:53
Women’s health, breast cancer, and self-care challenges ... 00:30:15
Feminist issues and autonomy in cancer care ... 00:31:45
Cancer as an opportunity for post-traumatic growth ... 00:36:25
Sarah Kennedy: clinical trials on natural appetite regulation ... 00:38:13
Long-term effects and usage patterns of Calocurb ... 00:39:14
Gut-brain axis, hunger hormones, and behavioral change ... 00:40:19
Our Amazing Sponsors:
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Dr. Bill Lawrence Episode
📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
Today, I’m joined by the insightful Dr. Victoria Mazzei, an integrative medicine physician and author of Heal Faster, for a conversation that’s all about practical recovery—when real life throws you a curveball. Dr. Mazzei brings decades of clinical wisdom to the table, blending cutting-edge science with the fundamentals of what our bodies actually need to heal after surgery, illness, or injury. She opens up about the untapped potential of preparing your body—physically, emotionally, and nutritionally—well before you ever reach an operating room.
Episode Timestamps:
Introduction: Extending Healthspan and Episode Focus ... 00:00:00
Prehabilitation: preparing body and mind for surgery ... 00:05:07
Why supplements are stopped before surgery ... 00:06:31
Building resilience with nutrition, sleep, and fitness ... 00:07:29
Starting healing before surgery with protein and micronutrients ... 00:07:54
Managing anesthesia, pain, and non-opioid strategies ... 00:09:54
Integrative pain solutions: acupuncture, imagery, and devices ... 00:11:30
Science behind prehab for faster and safer recovery ... 00:13:04
Physical, emotional, and nutritional pre-op readiness ... 00:14:41
Psychological prep for breast cancer and cardiac surgery ... 00:20:43
Role of food sensitivities and elimination diets ... 00:28:20
Reversing frailty: protein and resistance training ... 00:37:47
Essential amino acids and antioxidants for healing ... 00:41:09
Supplements to avoid and importance of transparency ... 00:46:19
When to restart supplements after surgery ... 00:51:11
Inflammation's healing role, and when to use ice ... 00:54:05
Environmental toxins, hormone disruption, and healing ... 01:00:11
Detox principles: reduce exposure, support elimination ... 01:06:28
Vagus nerve, stress, and enhancing recovery with breathwork ... 01:09:25
Learn more from Dr. Victoria Maizes below:
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Dr. Bill Lawrence Episode
📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
Today, I’m joined by the extraordinary Dr. Richard Horowitz, a board-certified internist, renowned Lyme disease specialist, and the author of Ending Chronic Illness—a book that’s become my new favorite reference guide for understanding the true roots of chronic disease. Dr. Richard Horowitz opens up about his journey from treating diabetes in upstate New York to becoming a medical detective in the heart of the country’s largest Lyme-endemic area, where standard medical training simply wasn’t enough. Patient by patient, he pieced together a radical new model for uncovering where inflammation really comes from—one that’s now transforming lives well beyond Lyme.
Take this FREE Questionnaire https://cangetbetter.com/symptoms/ to determine your likelihood of having Lyme and associated tick-borne disorders. His book then lays out what kind of testing and care could help.
Episode Timestamps:
Episode introduction and guest background ... 00:00:00
How Dr. Horowitz’s approach began with key patient cases ... 00:04:59
Developing the 16-point MSIDS model for inflammation ... 00:09:39
Impact of emotional trauma and mind-body connection ... 00:13:11
Addressing vagus nerve dysfunction and healing ... 00:15:22
Overlap among chronic diseases and resilience ... 00:24:41
The 16 factors behind chronic illness ... 00:25:32
Accelerated aging and inflammaging ... 00:27:13
Can healing reverse biological age? ... 00:28:06
Understanding inflammation’s dual role ... 00:33:08
Immune dysfunction and chronic illness ... 00:34:38
Annual checkups: new biomarkers and prevention ... 00:37:24
Alzheimer’s disease, infection, and amyloid ... 00:47:48
Practical use of the MSIDS model for symptoms ... 00:58:34
Essential lifestyle habits for healthspan ... 01:16:59
Learn more from Dr. Richard Horowitz below:
Our Amazing Sponsors:
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Original Instagram
Backup Instagram
Dr. Bill Lawrence Episode
📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
Today, I’m joined by Oliver Amdrup-Chamby, co-founder and CEO of Puori, for a lively and practical conversation about one of the hottest topics in health right now: protein. We dig into what “quality protein” actually means, why flashy marketing claims on snacks and cereals are often misleading, and how to know if your protein source is giving your body what it really needs—especially as you age.
Visit puori.com/NAT and use code NAT at checkout for 32% off Puori PW1 Grass-Fed Whey Protein when you start a subscription, plus a free shaker worth $30.
Episode Timestamps:
Welcome and listener engagement ... 00:00:00
Essential amino acids and importance of quality ... 00:07:09
Animal vs. plant protein efficacy ... 00:08:20
Marketing claims vs. real protein value ... 00:09:00
Carb-heavy diets and satiety challenges ... 00:12:51
Simple tips to boost protein at meals ... 00:14:35
Leucine, muscle synthesis, and healthy aging ... 00:17:48
Protein shakes for convenience and supplementation ... 00:19:57
DIAAS and measuring protein quality ... 00:41:57
Challenges for plant-based diets and key nutrients ... 00:43:34
Collagen’s value for tendons, gut, skin ... 00:48:10
Supplement as food: ease and convenience ... 00:53:05
Importance of batch testing for purity ... 00:56:16
Emerging regulation for transparency in protein products ... 01:00:05
Longevity protocol: resistance training, protein goals, quality ... 01:05:55
Action steps: smarter protein choices, label literacy ... 01:09:53
Learn more from Oliver Amdrup-Chamby below:
Our Amazing Sponsors:
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Backup Instagram
Dr. Bill Lawrence Episode
📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
Today, I’m joined by the insightful Dr. Michael Ruscio, a leading voice in integrative and functional medicine with an extraordinary depth of clinical and personal experience. Dr. Ruscio opens up about his 2-year journey battling intestinal parasites, back-to-back mold exposures, and chronic infections—experiences that completely reshaped his approach to mold, fungal overgrowth, biofilms, and the immune system.
Free Mold Assessment Guide: https://drruscio.com/guides/get-home-mold-guide/. More Info at DrRuscio.com.
Episode Timestamps:
Welcome and Introduction ... 00:00:00
Mold Triggers and Environmental Exposure ... 00:06:25
Limitations of High-Dose Binder Therapy ... 00:13:32
Approach to Food-Related Mold Sources ... 00:15:00
Resilience, Mycobium, and Clinical Blind Spots ... 00:16:42
Need for Better Diagnostic Testing ... 00:17:27
4-Part Diagnostic Framework for Mold ... 00:20:34
Importance of Sinus Symptoms and CT Scans ... 00:21:04
Mold’s Neurological Impact via Sinuses ... 00:27:04
Candida: Commensal vs. Pathogenic ... 00:30:15
Assessing the Cause and Timeline of Overgrowth ... 00:32:52
Clarifying Types of Fungal Infections ... 00:38:00
Natural and Pharmaceutical Antifungals ... 00:42:23
Sinus Treatment Challenges and Solutions ... 00:44:14
Posaconazole Outcomes in Sinus Fungus ... 00:45:41
Is There a "Normal" Amount of Fungus? ... 00:48:15
Mast Cell Activation and Extreme Food Reactivity ... 00:52:08
How to Navigate Mold and Yeast Testing ... 01:02:26
SSRD Diet, Probiotics, and Gut Reset Tactics ... 01:06:42
Herbals, Biofilms, and Clinical Protocols ... 01:08:38
Integrating Pharmaceuticals and Naturals ... 01:10:05
Importance of Finishing Antifungal Courses ... 01:11:05
Habits and Practices That Build Gut Resilience ... 01:16:49
Learn more from Dr. Michael Ruscio below:
Our Amazing Sponsors:
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Original Instagram
Backup Instagram
Dr. Bill Lawrence Episode
📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
Today, I’m joined by the remarkable Dr. Nathan Goodyear, a physician whose journey has taken him from conventional obstetrics and gynecology to the forefront of integrative oncology and systems biology. In our conversation, Dr. Goodyear reveals how his direct patient experience, a pivotal encounter with the immune impacts of vaginal mesh, and even his own personal health challenges led him to question medical dogma and dive into critical thinking and innovative cancer care.
Episode Timestamps:
Introduction to cancer and longevity overlap ... 00:00:00
Bridging integrative and conventional cancer care ... 00:05:00
War mentality in cancer treatment and its effects ... 00:06:37
Pivotal career shift and lessons from vaginal mesh ... 00:09:26
Critical thinking and innovation in medicine ... 00:11:27
Terrain, immune system, and chronic disease ... 00:12:40
Collaboration with Dr. Williams—debate for better patient outcomes ... 00:15:28
Discovery of the abscopal effect and immune engagement ... 00:20:21
Breaking down cancer “capsule” myths and tumor microenvironment ... 00:27:06
How tumors evade immune detection and why it matters ... 00:34:06
Limitations of systemic therapy and tumor-as-vaccine approach ... 00:36:12
Does everyone’s immune system have potential for this approach? ... 00:40:19
Crossover between cancer, aging, and longevity systems ... 00:44:10
Family, lifestyle, and community in prevention ... 00:55:13
Testosterone, cancer risk, and medical nuance ... 01:01:07
Innovative therapies: Liver, bone, and metastasis ... 01:06:19
Expanding access and right-to-try for patients ... 01:13:19
Closing thoughts and resources ... 01:16:11
Learn more from Dr. Nathan Goodyear below:
Website: https://williamscancerinstitute.com/
X: https://x.com/jasonwilliamsmd
YouTube: https://www.youtube.com/channel/UCgTNcIGyNcmZGjFJTy5Mh3Q
Instagram: https://www.instagram.com/williamscancerinstitute1?igsh=MXh4dTN0bHBvemlu
Facebook: https://www.facebook.com/immunotherapyforcancer1
Our Amazing Sponsors:
Nat's Links:
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Original Instagram
Backup Instagram
Dr. Bill Lawrence Episode
📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
Today, I’m joined by Dr. David Rabin, a triple-threat psychiatrist, neuroscientist, and author of A Simple Guide to Being Alive. In this episode, Dr. Rabin brings a refreshingly human perspective to one of life’s biggest questions: What does it really mean to be alive? We dive into why so many of us have been taught to treat our emotions as problems to fix, rather than signals to listen to, and explore the invisible cost of misunderstanding our own nervous systems.
Head to apolloneuro.com/NAT and use code NAT for $99 off and 1 year Smart Vibes Ai
Episode Timestamps:
Welcome, guest intro, and episode setup ... 00:00:00
Modern medicine’s blind spots: nervous system and trauma ... 00:04:09
Root cause over symptom management in mental health ... 00:06:07
What’s missing in medical education – why write the book ... 00:10:06
Learning, stress, and the importance of feeling safe ... 00:11:11
Screens, technology, and nervous system disconnection ... 00:17:01
Novelty, anxiety, and why newness can trigger fear ... 00:18:53
Reframing anxiety as helpful – the ABC method ... 00:21:13
Why suppressing emotion makes us stuck ... 00:26:37
Chronic stress: performance, burnout, and body costs ... 00:28:28
Right and wrong questions: self-judgment vs. self-care ... 00:36:22
Distress versus eustress, hormesis, and resilience ... 00:39:17
The health and longevity power of soothing touch and intimacy ... 00:46:24
Pets, connection, and Apollo Neuro technology ... 00:51:03
How Apollo supports vagus nerve health ... 00:54:22
Using, learning from, and eventually relying less on Apollo ... 01:09:00
HRV, vagus nerve activity, and democratizing longevity ... 01:14:44
Playful nervous system comparisons (laughter, dance, etc.) ... 01:21:09
The greatest lesson: science, togetherness, and ending loneliness ... 01:23:39
Our Amazing Sponsors:
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Original Instagram
Backup Instagram
Dr. Bill Lawrence Episode
📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/.
Today, I’m joined by Sarah Kennedy of CaloCurb, a remarkable veterinarian-turned-nutrition expert who brings decades of hands-on research and real-world insight to the weight loss conversation. Sarah shares her unique journey from studying animal nutrition—where performance and health are paramount—to spearheading groundbreaking human clinical trials in appetite regulation, hunger hormones, and innovative, natural GLP-1 strategies.
Learn more about Calocurb at https://www.calocurb.com/?sca_ref=12093749.1gzbGYmTyb and use code NAT for 10% off.
Episode Timestamps:
Welcome and gratitude for listeners ... 00:00:00
Calocurb and GLP-1 context ... 00:02:07
Bitter taste receptors and appetite suppression ... 00:17:13
Discovery of hops as key bitter extract ... 00:20:13
Human trials: hormone changes and calorie reduction ... 00:21:00Comparison to pharmaceutical GLP-1s ... 00:21:44
Appetite studies: women vs. men ... 00:25:15
Recent clinical trial: fat loss, muscle preservation ... 00:28:37
Mechanisms: natural vs. synthetic hormone activation ... 00:31:38
Lasting effects after stopping Calocurb ... 00:34:16
Practical use cases: intermittent fasting, holidays, maintenance ... 00:36:33
Comparison: behavioral effects and food noise ... 00:37:03
Side effects: GI motility, constipation, and laxative effect ... 00:45:03
Calocurb vs. other "GLP-1" supplements ... 00:51:53
Blood sugar effects and limitations ... 00:55:51
Managing late eating and habit change ... 00:59:10
Safety considerations (GI conditions, pregnancy) ... 01:03:23
Older adults, menopause, and ongoing research ... 01:04:50
PYY, muscle satellite cells, and aging ... 01:07:36
Why it's hard to "just use food" for appetite control ... 01:08:41
Coming off pharmaceuticals: rebooting gut-brain axis ... 01:10:25
Open research questions and clinical focus ... 01:12:30
Natural vs. synthetic: critical difference explained ... 01:14:26
Sarah Kennedy's personal experience with food and Calocurb ... 01:16:16
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