Today, I'm flying solo for a deep—well, more like a just-scratching-the-surface—dive into one of the body's most fascinating hormones: melatonin. After getting so many of your questions about how melatonin really works, whether it's just about sleep, and how it might support healthy aging, I decided to tackle all those hot topics head-on in this episode.

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Melatonin Product mentioned: https://symphonynaturalhealth.com/?_ef_transaction_id=&oid=2&affid=161 and the code is NAT

What we discuss:

Why melatonin is complex; plans for future episodes ... 00:00:42

Melatonin as darkness hormone; comparison with vitamin D ... 00:01:51

Top science-backed facts about melatonin ... 00:03:25

Light exposure's impact and blue light mitigation tips ... 00:05:09

Bioidentical melatonin in plants and animals; supplement notes ... 00:06:41

Production in pineal gland and gut; unique roles ... 00:07:24

Melatonin decline with age and rationale for supplementation ... 00:09:02

Calcified pineal gland and bioregulator benefits ... 00:10:03

Melatonin's antioxidant, skin, mitochondrial, and anti-cancer effects ... 00:10:37

High-dose melatonin in research and cancer ... 00:12:21

Melatonin from food—phytomelatonin vs. synthetic ... 00:18:37

Supplements: dependency, dosing, and genetic factors ... 00:21:57

Practical tips for dosing and timing ... 00:23:22

Potential drug interactions and safety ... 00:27:38

Wide-ranging health impacts and future research ... 00:28:26

Product recommendations and tracking results ... 00:29:55

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Today, I'm welcoming back Dr. Jeffrey Gross, a true pioneer in the regenerative longevity space. You might remember our earlier episode where we explored the transformative science of human exosomes—but today, we're going even further, straight into the fascinating world of plant exosomes.

Visit https://recellnutra.com/?ref=NAT and use code NAT for 10% off

What we discuss:

Plant exosomes intro ... 00:04:23

Gut health/minerals ... 00:05:18

Why plant exosomes ... 00:08:09

Exosomes vs. liposomes ... 00:09:35

Bioavailability ... 00:12:12

Phytonutrients ... 00:17:26

Resveratrol ... 00:18:17

Quercetin ... 00:20:30

Glutathione ... 00:22:01

Antioxidant enzymes ... 00:24:02

Fruit yield per cap ... 00:25:32

Melatonin ... 00:26:55

Oral bioavailability ... 00:29:29

Research summary ... 00:30:10

Sirtuin 1/ROS ... 00:31:29

Prepping for joint regen ... 00:42:05

Cartilage success ... 00:44:00

European edge ... 00:47:48

B vitamins ... 00:48:25

Microbiome ... 00:51:50

Fisetin/dosing ... 00:53:22

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Today, I'm joined by the brilliant Dr. Vincent Pedre, one of the most sought-after experts in functional medicine and an incredible advocate for what he calls "gut-centric medicine." Together, we explore how your emotions and beliefs directly impact your gut, why there is no one-size-fits-all approach to gut healing, and the practical steps you can take to support your body's natural balance.

What we discuss:

Dr. Pedre's personal and medical background ... 00:06:05

Mind-body connection and overcoming fear through meditation ... 00:09:16

Impact of antibiotics and gut health journey ... 00:18:06

Energy healing, boundaries, and the empath-practitioner challenge ... 00:21:05

Gut-brain connection and integrating mindset in healing ... 00:24:45

Mindset, mantras, and patient transformation ... 00:30:04

Personalizing gut protocols and addressing resistance ... 00:39:03

Tools: intuitive eating, true cravings vs. microbiome-driven urges ... 00:47:45

No one-size-fits-all: diversity and personalized gut diets ... 00:54:08

How the Gut Smart Protocol tailors recommendations ... 00:58:54

Probiotics, spore-based options, and gut support basics ... 01:02:48

Coffee as a gut health microhabit (toxins, plastics, quality) ... 01:06:33

Happy Gut Coffee: rationale, tips, and final takeaways ... 01:09:11

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Mitolux NEW Second Generation - This second-generation red and near-infrared light therapy panel hits all the marks. Two new wavelengths—810nm and 940nm—target brain performance, deep muscle recovery, and circulation. I use GAMA mode for focus, and Fireplace 2 to wind down. Get a Mitolux BTS2 Sunlamp for 10% off at https://mitolux.com/NAT10, NAT10 will be automatically applied at checkout.

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In this episode, I sit down with Dr. Ian White—one of the most exciting researchers in regenerative medicine today. If you're even a little bit curious about how to hack aging or have heard the buzz about things like plasma exchanges, exosomes, or why on earth lobsters never seem to grow old, you're in for a treat.

What we discuss:

Expanding autologous hematopoietic stem cells and FDA challenges ... 00:08:28

Heterochronic parabiosis, plasma exchange, and aging signals ... 00:17:35

Nature's clues: Lobsters, jellyfish, and biological age reset ... 00:24:02

Entropy, epigenetics, and limiting factors in aging ... 00:27:56

Vision: Youthful healthspan, not just longer lifespan ... 00:32:43

Amniotic fluid as a source of rejuvenation ... 00:36:01

Therapeutic results: burns, ulcers, and immune modulation ... 01:03:18

Exosomes vs. stem cells: Definitions and market problems ... 01:02:31

How exosomes function and the importance of source ... 00:51:23

Ensuring safe and effective regenerative therapies ... 01:00:10

Guidance for patients interested in exosome therapy ... 01:09:42

Dr. White's research legacy and goals ... 01:14:04

Our Amazing Sponsors:

Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there.

NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase.

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Today, I've got something special for you: a solo episode where I look back at the past six months and handpick the five episodes and ideas that truly changed the game for me—and, based on your feedback, for many of you too.

Episodes from this podcast:

#300: Breast Cancer Overdiagnosis, Mammogram Myths, The REAL Risks For Women And Bold NEW Alternatives With Dr. Jenn Simmons

#302: If You Have Creeky or Painful Joints and BIG Dreams of Staying Active, These Nonsurgical Solutions Are The NEW Way Forward - With Dr. Jeff Gross

#309: Cordycepin and Methylene Blue: Two Game-Changers For Better Energy, Focus, Sleep, and So Much More With Dr. Scott Sherr

#312: Age-Defying Bone Health: Preventing Osteoporosis with Science-Backed Interventions and Reversal Techniques You Can Try TODAY With Doug Lucas

#318: Lies He Taught In Medical School: The METABOLIC Secret To Reversing Chronic Disease with Dr. Robert Lufkin

What I discuss:

Exosomes for regeneration: cartilage, bone, and joint repair ... 00:02:19

Exosomes vs. PRP and stem cells—key differences ... 00:05:20

Managing inflammation before regenerative treatments ... 00:06:09

Exosomes in neurology & anti-aging ... 00:07:01

Regulation, safety, and advances in exosome therapy ... 00:08:33

Mammogram controversy: risks, overdiagnosis, and dense breasts ... 00:10:00

Alternatives: QT scan benefits and radiation-free screening ... 00:15:21

Optimizing mitochondrial health—importance & methylene blue ... 00:18:28

Widespread mitochondrial dysfunction & modern disruptors ... 00:21:03

How methylene blue supports energy & cautions ... 00:23:17

Bone health: density vs. quality, collagen, and vibration plates ... 00:31:17

Mechanical input & gaps in traditional osteoporosis care ... 00:34:22

Lifestyle reversal of chronic disease ... 00:37:15

Medical system limitations & patient health agency ... 00:39:25

Fasting and metabolic health—power & nuance ... 00:48:06

Our Amazing Sponsors:

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I'm your host, Nathalie Niddam, and today I'm thrilled to bring you a truly fascinating conversation with Dr. Stephanie Canestraro—a chiropractor, functional medicine practitioner, and someone with an incredible personal story about overcoming chronic illness. Dr. Canestraro works with elite athletes, including NHL players, but her expertise comes from her own journey through mysterious health challenges that eventually led her to discover the vital role of the lymphatic system.

What we discuss:

Dr. Canestraro's personal health journey and lymphatic issues ... 00:07:58

Explanation of the lymphatic system ... 00:10:33

Superficial vs. deep lymphatics and fascia's role ... 00:15:20

Personal stories of lymphatic stagnation and deep lymph solutions ... 00:17:03

Why movement isn't always enough for lymph flow ... 00:2447

Modern challenges: EMFs, toxins, fascia, and liver ... 00:25:00

Lymph, anxiety, and the vagus nerve ... 00:35:40

Tools and approaches for lymph support ... 00:39:22

Body-wide impact of fascia ... 00:43:47

Frequency medicine and resilience strategies ... 00:51:16

Our Amazing Sponsors:

Bio-Shield by Young Goose - It's a broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light—aka the stuff pouring out of your laptop right now. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.

Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there.

OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order.

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In this episode, I'm thrilled to sit down with Dr. Robert Melillo, a clinical neuroscientist with nearly 40 years of experience decoding the mysteries of the brain and how our modern lifestyle—and especially technology—are changing it.

If you've ever worried about what all that screen time means for your kids' developing brains (or your own), this conversation is going to give you a whole new perspective.

What we discuss:

Left/right brain imbalance and modern tech's impact ... 00:12:31

Gut health, peptides, and foundational health tips ... 00:05:37

Dr. Melillo's journey, research, and clinical experience ... 00:08:04

Technology's rapid evolution vs. brain adaptation ... 00:12:31

Making brain health more accessible ... 00:15:39

Biohacking brain interventions: risks and basics ... 00:17:34

ADHD, OCD, and the connectivity problem ... 00:20:14

How brain imbalances manifest and can be changed ... 00:23:45

Root causes: movement, milestones, and environment ... 00:39:09

Functional treatment: targeted, practical steps ... 00:47:25

Technology, lifestyle, and the left-brain epidemic ... 00:55:50

Correcting imbalances at any age ... 01:06:02

Dr. Melillo's resources and how to learn more ... 01:14:38

Our Amazing Sponsors:

CAROL Bike: With its cutting-edge, science-backed method, CAROL Bike can boost your VO2max by 12% in just 8 weeks—essentially rewinding your fitness clock by a decade. The folks at CAROL Bike are offering a 100-day FREE trial! Visit http://carolbike.pxf.io/Nat or use code NAT100 for a free 100-day trial.

Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. The ingredients are unmatched! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off.

Berkeley Life: Nitric oxide is key for blood flow, energy, brain clarity, and even healthy blood pressure. When you subscribe at BerkeleyLife.com/NAT, you'll get a free tube of 50 nitric oxide test strips with your first delivery, so you can track how your body responds. Visit BerkeleyLife.com/NAT and click "Subscribe" to get started.

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Today I'm joined by my friend and fellow biohacker, Dave Korsunsky, founder of Heads Up Health. In this episode, we take you on a journey through the evolution of biohacking—from the early days when continuous glucose monitors were a novelty and cryotherapy sounded like science fiction, all the way to the sophisticated, data-driven tools we have at our fingertips today.

What we discuss:

Dave's journey: Heads Up Health and the rise of health data ... 00:08:18

Making sense of health metrics: Knowing if protocols work ... 00:10:06

GLP-1s: muscle loss risks, proper technique, and hydration ... 00:16:18

Clinical stories: HRV, autoimmune disease, and diabetes management ... 00:25:57

The foundational power of sleep, hydration, and micro-experiments ... 00:34:14

Core metrics: HRV, blood sugar, sleep, and their significance ... 00:40:46

The promise and impact of new longevity diagnostics ... 00:50:42

No-equipment longevity tests: grip, hang, balance, sit-to-stand ... 01:00:31

Aggregate your data and run micro-experiments ... 01:05:25

Our Amazing Sponsors:

Bio-Shield by Young Goose - It's a broad-spectrum serum that protects against UVA/UVB, infrared, AND high-energy visible (HEV) light—aka the stuff pouring out of your laptop right now. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer.

Troscriptions - Blue Cannatine - think of it as a small but mighty brain boost that melts in your mouth. A precise blend of methylene blue, caffeine, CBD, and microdosed nicotine gives me steady energy, focus, and mental clarity without the usual ups and downs. Try it for yourself at troscriptions.com and use code NAT10 for 10% off. Get in the zone and stay there.

OraltidePro - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), Helps with enamel remineralization, Reduces bacteria growth and etching and Fills slots in damaged enamel. check out OraltidePro at profound-health.com and use code NAT15 for 15% off your first order.

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Welcome back to the Longevity Podcast! I'm your host, Nathalie Niddam—a nutritionist, human potential and epigenetic coach, and devoted biohacker. Today, I'm tackling one of your most-requested topics: Thymosin Alpha 1, a peptide that keeps lighting up conversations in my communities.

Resources from the episode:

Thymosin alpha 1: A comprehensive review of the literature

What we discuss:

Overview of Thymosin alpha-1 ... 00:02:16

Medical uses, orphan drug status, and immune effects ... 00:03:53

Contraindications and vaccine adjuvant potential ... 00:05:01

Benefits in sepsis, infections, and elderly ... 00:07:40

Mechanisms of action and immune modulation ... 00:08:31

Antimicrobial properties and hospital study highlights ... 00:09:13

Support in aging, cancer, chemo, and mold toxicity ... 00:09:53

Cautions for autoimmune and sensitive individuals ... 00:13:04

Potential cancer therapy support and anti-inflammatory effects ... 00:14:48

Wound healing, safety, and administration ... 00:20:23

Risks, final cautions, and practitioner advice ... 00:23:15

App resource, newsletter, and wrap-up ... 00:25:24

Our Amazing Sponsors:

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Welcome back to the Longevity Podcast! In this episode, I have the pleasure of sitting down with James Strole, a beacon in the radical longevity space and the visionary founder behind People Unlimited and RAADfest. James shares the personal journey that led him into the world of life extension—shaped by a spiritually open-minded mother, a pivotal loss, and a lifelong desire to challenge the idea that aging is inevitable.

Get 10% off your tickets to RAADfest using code: "niddam"

What we discuss:

James Strole's personal journey to radical longevity ... 00:04:00

Spiritual roots and early inspiration ... 00:10:00

Transition from spiritual to scientific approaches ... 00:13:00

Launching RAADfest and the shift toward hard science ... 00:16:00

Evolution of the longevity movement over the decade ... 00:21:00

Access to longevity innovations and RAAD Clinics ... 00:22:00

Most exciting developments: gene therapy and age reversal ... 00:24:00

Daily longevity pillars: diet, movement, mindset ... 00:26:00

Mindset and embracing the possibility of immortality ... 00:35:00

Overcoming skepticism and "against nature" arguments ... 00:41:00

Societal implications of extreme longevity ... 00:44:00

Are we at the tipping point? The "era of immortality" ... 00:47:00

Advice for newcomers: join the conversation and community ... 00:50:00

Our Amazing Sponsors:

NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase.

Mitoblue by Wizard Sciences - Everything in the formula is there to help you think clearer, move better, and stay resilient—mentally and physically - Methylene Blue, NMN, PQQ, Apigenin and Ginseng

Go to wizardsciences.com and look for MitoBlue. Use code NAT15 at checkout to get 15% off your purchase.

Mimio: A supplement that gives you all the cellular, metabolic, and longevity benefits of a prolonged fast—even on the days when you're eating normally. Visit mimiohealth.com/nat and use code NAT FOR 20% off your first single purchase or subscription order.

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