The Hunter Williams Podcast

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links

KPV is the most underrated peptide out there. Almost nobody talks about it. In my opinion it should be one of the most demanded peptides we have. If I had to choose, I'd take it over BPC and TB-500 every single time.Here's why. KPV is a tiny three amino acid fragment of alpha-MSH. It directly blocks NF-kappa B, the master switch your body uses to turn inflammation on. Most peptides work around the edges. KPV shuts the alarm off at the door.In this one I cover all of it. What KPV is and how it works. Who actually benefits. Dosing by tier and by purpose. How to stack it with BPC, TB-500, LL-37, and your GLP-1. What to track on bloodwork. Cycling, sequencing, troubleshooting, and a full FAQ.If you've ever run a protocol that worked and then stalled out, this one is for you. Inflammation is almost always the rate-limiting step in healing.Make sure you're on the email list. And come join us in the Axion Collective for live coaching every Thursday.⚠️ For research and entertainment purposes only. ⚠️

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links

Tesamorelin is one of the few peptides I've seen actually move the needle on body composition. So I made a full masterclass on it.

This is the user's guide as it stands in 2026. I cover what tesamorelin is, how it works, and the best practices I'd recommend for using it.

We get into the growth hormone axis and why a GHRH is different from a GHRP. I break down the clinical data, the 15% visceral fat reduction, the liver fat numbers, and the cognition research almost nobody talks about.

Then we get practical. Dosing, timing, fasted injections, and the cycling patterns I actually use. I share why I stay at one milligram instead of two and what the water retention tradeoff looks like at higher doses.

I also cover stacking with testosterone and GLP-1s, reconstitution, injection technique, side effects, and the people who should skip this one entirely.

I'm honest about the limits too. Some of this evidence is strong and some of it isn't. I tell you which is which.

If you're thinking about tesamorelin or already using it, this is everything I'd want you to know.

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links

Links, cheatsheet, private group and more: https://hunterwilliamshealth.com/links

TB-500 spends way too much time in BPC-157's shadow. I wanted to fix that.

This is my full TB-500 masterclass. I go deep on what this peptide actually does, and why it works so differently than BPC even though we lump them together as the Wolverine stack.

First I clear up the confusion between TB-500 and thymosin beta-4, because most people have no idea what they're actually buying. Then I break down the mechanism in plain language. Think of TB-500 as the foreman on a job site, moving the right materials to the right injury at the right time.

I cover who it's for, who should skip it, and my full dosing tiers from general recovery up to severe injury. We get into cycling, reconstitution, injection technique, and how to stack it with BPC, GHK, and the growth hormone peptides.

I also answer the big questions. Is it legal? Will it cause cancer? Will it touch your hormones? Does it grow hair?

If you want more from me, get on the email list and check out the Axion Collective. Both links are in my bio.

Enjoy this one. I love TB-500.

Taylor and I are back for another Reader Mailbag. This one covers a lot of ground.

We start with anhedonia on GLP-1s because the questions on this have been nonstop. People are experiencing it on Semaglutide, Tirzepatide, and Retatrutide and we break down why it happens, whether it is dose related, and what you can actually do about it.

From there we get into the Reta and heart rate debate, Taylor's GLP rotation strategy, and whether the cardiovascular tradeoffs are actually worth worrying about.

Then Taylor takes over for the hormone optimization section for young women in their twenties and thirties. Her personal story on this one is worth watching alone.

We also cover accidental peptide overdoses, what to do when it happens, and finish with teen acne solutions using peptides and topicals.

Submit your questions for the next episode at the link below.

For research and entertainment purposes only.

Links, cheatsheet, private group and more 👇https://hunterwilliamshealth.com/links

Hey everybody, this is the May 2026 Q&A video, and we made it through a packed hour of your questions. I had so many submitted that I had to print them off and group them by category to get through them all.

All My Links Here: ⁠https://hunterwilliamshealth.com/links⁠

We cover a lot of ground. GLPs and fertility, hunger on retatrutide, dopamine differences between Sema, Tirz, and Retta, GLP side effects and how to manage them. Then we move into hormones and HRT, including the right starting dose of testosterone, kisspeptin for fertility, progesterone dosing for women, and why so many doctors are starting guys way too low.

From there we get into GH peptides and IGF cycling, my full injury healing stack, autoimmune protocols, cognitive stacks for studying, cosmetic questions, heart health, bone density, thyroid, and a long miscellaneous section covering rapamycin, MOTS-c, prostate peptides, traveling with peptides, and more.

I also share the new AI chat tool I built that is trained only on my content. It is at chat.hunterwilliamshealth.com if you want to play with it.

Thanks for submitting these. Keep them coming. See you in June.

⚠️ For research and entertainment purposes only. ⚠️

All links here: ⁠https://hunterwilliamshealth.com/links

SS-31 continues to be one of my favorite peptides of all time, and the more data that comes out on it, the more I think every person over 25 has a use case for it.

In this masterclass, I'm breaking down everything I know about SS-31. We cover what it actually does at the cellular level, why it's the first FDA-approved mitochondrial peptide, and why it works differently than almost every other peptide out there. No receptor binding. It goes inside your cells, binds to cardiolipin, and stabilizes the structure of your mitochondria.

I walk through the three dosing tiers I use with people, my take on cycling, why I run SS-31 before MOTS-c, how to stack it with GLPs, GH peptides, and the healing peptides, and what to actually track when you're on it. I also cover the troubleshooting stuff people ask me about constantly. Why don't I feel anything? Should I cycle? What about the headaches in the first two weeks?

If you're a clinician or just researching for yourself, this is the complete user's guide.

For entertainment purposes only.

Timestamps

00:00 Intro

01:00 What this masterclass covers

03:18 Why SS-31 matters and what makes it different

03:46 FDA approval and the Forzenity brand name

04:50 Peptide foundations and how SS-31 is made

05:52 The SS-31 sequence and the Seto-Schiller naming origin

06:40 Mitochondria 101 and why ATP matters

07:28 Mitochondrial dysfunction across chronic disease

08:34 Cardiolipin, cristae, and Barth syndrome

09:34 Why SS-31 is not a direct antioxidant

10:46 How SS-31 actually works (the upstream Godfather effect)

11:12 Why no receptor means no desensitization

13:36 Who SS-31 is for (mid-30s, athletes, post-illness, metabolic dysfunction)

14:24 Who should skip it

15:34 The three-tier dosing ladder

16:54 The FDA-approved 40mg dose and diminishing returns

19:08 Dosing by goal (longevity, performance, recovery, healing)

19:48 Cycling logic and the 8-12 week framework

20:22 When to dose (morning vs night)

21:24 What to expect and when (week-by-week timeline)

22:20 Why cycle if it doesn't desensitize

24:24 SS-31 before MOTS-c (the structural engineer vs operations manager)

26:18 Reconstitution and injection technique

28:22 What to track (subjective markers and biomarkers)

29:18 Stacking with MOTS-c, Humanin, BPC, GH peptides, and GLPs

31:28 Stacking for cognition and visceral fat

32:26 Troubleshooting "I don't feel anything"

33:54 Injection site reactions

34:36 When to discontinue and the first-two-week headache window

35:52 FAQ (legality, MitoQ comparison, oral routes, intranasal)

36:54 Use cases (weight loss, long COVID, athletic performance, TRT, kids)

37:54 Research grade vs pharmaceutical cost difference

38:22 Future outlook (AMD, sarcopenia, SBT-272, oral bioavailability)

40:30 Final thoughts and where SS-31 sits in the broader picture

42:20 Closing

All links here: ⁠https://hunterwilliamshealth.com/links

Timestamps:

00:00 Intro

01:00 Why I'm making this video

04:00 The plan: peptides with direct anti-cancer evidence

06:02 AOD-9604 and HGH Frag 176-191

07:42 BPC-157

09:54 DSIP (Delta Sleep Inducing Peptide)

11:08 Epitalon

12:30 Follistatin 344

13:30 GHK-Cu

14:36 Kisspeptin

15:58 KPV

17:18 LL-37

18:46 Melanotan 2

19:58 MOTS-c

21:12 Retatrutide

22:34 Semaglutide

23:40 SS-31

24:38 Thymalin

25:26 Thymosin Alpha-1

27:00 Tirzepatide

27:30 VIP (Vasoactive Intestinal Peptide)

28:06 Bottom line and closing thoughts

Description

If you spend any time in the peptide social media world, you've heard it. "Peptides cause cancer." It's the easiest way to scare someone off something, and a lot of people do it without ever showing you a single study.

So I went and pulled the studies. In this video I walk through every peptide on the popular research peptide list that actually has direct anti-cancer evidence in the published literature. Not theory. Not mechanism guesses. Actual studies in cells, animals, and in some cases, humans.

You'll see what the research says about BPC-157, GHK-Cu, Epitalon, KPV, LL-37, Thymosin Alpha-1, MOTS-c, semaglutide, tirzepatide, retatrutide, and a handful more. Some of this evidence is strong. Some is preliminary. I'm honest about both.

This is not medical advice and I'm not telling you peptides cure cancer. That's not what the data says and that's not what I'm claiming. What I am saying is that the next time someone hits you with a 60 second clip telling you peptides cause cancer, you'll have something more substantial to weigh it against.

All study links below.

📚 Studies Referenced (in order of appearance)

AOD-9604 / HGH Frag 176-191 

https://pmc.ncbi.nlm.nih.gov/articles/PMC9249349/

BPC-157 https://journals.lww.com/melanomaresearch/citation/2004/08000/bpc_157_inhibits_cell_growth_and_vegf_signalling.50.aspx https://pubmed.ncbi.nlm.nih.gov/29886825/

DSIP

https://pubmed.ncbi.nlm.nih.gov/12782416/

Epitalon 

https://pubmed.ncbi.nlm.nih.gov/14501183/ https://pubmed.ncbi.nlm.nih.gov/12209581/ https://pubmed.ncbi.nlm.nih.gov/12049808/

Follistatin 344 

https://pmc.ncbi.nlm.nih.gov/articles/PMC9633376/

GHK-Cu 

https://neoplasiaresearch.com/index.php/jao/article/view/217 https://www.lidsen.com/journals/genetics/genetics-05-02-128

Kisspeptin 

https://pubmed.ncbi.nlm.nih.gov/8944003/ https://pubmed.ncbi.nlm.nih.gov/28944853/

KPV 

https://pmc.ncbi.nlm.nih.gov/articles/PMC4957955/

LL-37 

https://pmc.ncbi.nlm.nih.gov/articles/PMC3910284/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3659029/

Melanotan 2 

https://pmc.ncbi.nlm.nih.gov/articles/PMC7013727/

MOTS-c 

https://pmc.ncbi.nlm.nih.gov/articles/PMC11578304/

Retatrutide 

https://pmc.ncbi.nlm.nih.gov/articles/PMC11908972/

Semaglutide 

https://pmc.ncbi.nlm.nih.gov/articles/PMC11227080/ https://pubmed.ncbi.nlm.nih.gov/38683947/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12587238/

SS-31 

https://pmc.ncbi.nlm.nih.gov/articles/PMC7923037/

Thymalin 

https://pubmed.ncbi.nlm.nih.gov/6752596/ https://pubmed.ncbi.nlm.nih.gov/29797130/

Thymosin Alpha-1 

https://pubmed.ncbi.nlm.nih.gov/8652276/ https://pmc.ncbi.nlm.nih.gov/articles/PMC2748379/ https://pubmed.ncbi.nlm.nih.gov/20194853/ https://pubmed.ncbi.nlm.nih.gov/27900029/ https://pubmed.ncbi.nlm.nih.gov/30063847/

Tirzepatide 

https://www.biorxiv.org/content/10.1101/2024.01.20.576484v1 https://aacrjournals.org/cancerres/article/84/6_Supplement/2188/738498/Abstract-2188-Tirzepatide-treatment-restores

VIP

https://pmc.ncbi.nlm.nih.gov/articles/PMC6317926/

All links here: https://hunterwilliamshealth.com/links

00:00 — Intro and why I'm doing these masterclasses

02:42 — What we're covering and the regulatory timeline

04:04 — The two users: weight loss vs longevity

05:30 — What Retatrutide actually does (the three receptors)

06:50 — Why the glucagon receptor makes Retatrutide different

07:54 — Weight loss trial data (1mg to 12mg)

10:50 — The longevity data: liver fat, ApoB, blood pressure

13:14 — Who the lean biohacker user is

13:50 — The titration playbook

15:32 — Once weekly vs split dosing

19:50 — Morning vs night injections

21:02 — How far to push the dose (why 8mg is the ceiling)

22:50 — How long to stay on and the regain problem

25:44 — Longevity maintenance protocol

26:34 — Lean user protocol

27:24 — Protein and training are non-negotiable

29:06 — Side effects and how to manage them

30:20 — The heart rate question and why I use taurine

32:00 — The weird skin sensitivity issue

33:48 — Pairing Retatrutide with testosterone

35:56 — Drug interactions (blood pressure, thyroid, insulin)

37:02 — Metrics that matter

38:42 — How to cycle off correctly

39:54 — The most common mistakes

40:42 — How to start, what to do if you plateau

43:04 — Should you switch from Tirzepatide?

45:28 — Combining Retatrutide with other peptides

46:50 — The Ten Commandments of Retatrutide use

47:50 — The bottom line

Today's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide.

I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first.

If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients.

Let me know what you think. I plan on doing many more of these on every peptide that matters.

⚠️ For research and entertainment purposes only. ⚠️