The Hunter Williams Podcast

All Links Here: https://hunterwilliamshealth.com/links

If you do everything right and still feel off, this episode is for you.

I sat down with Peter Cowan, a quantum biology practitioner and environmental health investigator who got chronically sick from EMF exposure, walked away from Silicon Valley, and spent years figuring out why on his own. Peter's Substack series on the San Francisco 49ers, who practice and play right next to a power substation, is some of the most compelling EMF research I've seen anywhere.

We covered the EMF checklist anyone can run at home, the mitochondrial mechanism behind oxidative stress from magnetic fields, how EMF disrupts the cortisol and melatonin cycle that drives your testosterone, why pre-sunrise workouts under fluorescent lights are doing more damage than most people realize, and the three-pronged light protocol that took Peter's testosterone from 437 to over 800.

Follow Peter: https://peteranthonycowan.substack.com/

For research and entertainment purposes only.

👇 ALL MY LINKS IN ONE PLACE

https://hunterwilliamshealth.com/links

👇 ALL MY LINKS IN ONE PLACE

https://hunterwilliamshealth.com/links

PE-22-28 is one of those peptides almost nobody is talking about, and I think that's a shame. In this episode I walk you through what it is, how it works, and why I'd put it in the antidepressant category before I'd call it a true nootropic.

I get into the background as an optimized analogue of spadin, the TREK-1 channel inhibition that drives the effect, and the downstream impact on BDNF, synaptogenesis, and neuroinflammation. I also cover the part most people care about: the rapid antidepressant onset, usually around four days, versus the three to four weeks you wait on a typical SSRI.

From there I share the dosing protocol I've been using on myself, including a four-on, three-off cycle to keep tolerance low, plus what I've noticed in terms of mood, mental energy, and the lack of any real come-down or withdrawal.

I'm not saying this is a cure for depression. Depression is multifaceted and deserves a multifaceted approach. But if you need something to help get you out of the hole and back into the habits that actually move the needle, PE-22-28 is worth knowing about.

Hunter and Taylor are back for another deep dive Reader Mailbag. Real questions, real answers, no shortcuts.

This week: traveling with peptides and TRT through customs, fixing glutathione injection pain, melanatan 1 vs 2 and skin cancer risk, severe female insomnia and perimenopause sleep protocols, retatrutide plateaus and GLP-1 desensitization, and how to actually build a peptide stack using the bleeding neck framework.

Whether you're new to peptides or deep in your optimization journey this one has something for everyone.

Submit your questions for the next episode at the link below.

For research and entertainment purposes only.

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👇 ALL MY LINKS IN ONE PLACE

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GLP-1s like retatrutide are the kings of fat loss. No argument there. But what do you actually do when you're cycling off, when GLP-1s aren't on the table, or when you want to stack something alongside your GLP-1 so you don't have to escalate the dose?

In this video I rank 20 non-GLP-1 fat loss compounds from F-tier to S-tier. Most are peptides. A few are small molecules. Some I use all the time. Some I would never touch.

I cover the mechanisms, the dosing protocols I actually run, the side effects I've personally experienced, and where each one fits in a real fat loss program. You'll get my honest take on adipotide, AOD-9604, sermorelin, setmelanotide, tesofensine, SS-31, cagrilintide, IGF-1 LR3, cardarine, CJC/ipamorelin, MOTS-c, 5-amino-1MQ, BAM15, SLU-PP-332, ATX-304, mirabegron, albuterol, HGH, and tesamorelin.

Hormones and lifestyle come first. Always. But once those are dialed in, these are the tools worth knowing about.

If you want my peptide cheat sheet and links to everything I use, check the description 

below. And if you want to ask me questions directly, come hang out in the Axion Collective.

All links here: https://hunterwilliamshealth.com/links

👇 ALL MY LINKS IN ONE PLACE

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Low-dose naltrexone is one of my favorite compounds out there, and in this updated 2026 episode I'm breaking down why it deserves a spot in your protocol. I cover the four mechanisms that make LDN work: the endorphin rebound, the OGF/OGFR axis, TLR4 antagonism, and broad anti-inflammatory signaling. Then I get into where LDN actually shines clinically. Autoimmune conditions like Hashimoto's and Crohn's. Chronic pain and fibromyalgia. Depression. PCOS and fertility. Even skin issues like acne, which I've personally dealt with for years.

But the part I'm most excited about is how LDN stacks with hormones and peptides. I walk through why it pairs so well with TRT, estrogen, and thyroid optimization, and then I get into specific peptide combos including BPC-157, TB-500, thymosin alpha-1, KPV, SS-31, and GLP-1 agonists. I also share why LDN might let you stay at lower GLP-1 doses for longer.

I cover dosing, titration, side effects, and my own experience cycling versus staying on continuously. If you're already optimizing with peptides and hormones, LDN might be that last five to ten percent that makes everything else work better.

00:00 – Intro and why LDN deserves an updated episode

02:22 – Why LDN belongs in your protocol (40-year safety record, broad benefits)

03:44 – The history of LDN and Dr. Bernard Bihari's HIV discovery

05:42 – The four mechanisms of action explained

06:30 – The OGF/OGFR axis and cancer applications

07:30 – TLR4 antagonism and the immune benefits

09:24 – Where LDN shines: autoimmune, pain, gut, depression, PCOS, skin

13:14 – Dosing, titration, and timing (night vs morning)

15:06 – Side effects, contraindications, and safety

16:14 – LDN and hormone replacement therapy synergy

18:34 – LDN for men on TRT, sexual function, and cortisol

20:48 – LDN stacked with peptides (BPC-157, TB-500, KPV, SS-31, GLP-1s, TA-1)

28:38 – My personal take on cycling vs daily use

30:16 – Closing thoughts

Timestamps

Every question that came in over the last month. No filters, no shortcuts. This is the April 2026 edition of the solo Q&A and Hunter covers everything from women's hormone optimization and PCOS to vasectomy impacts on men's health, peptides for neurological conditions, bioregulator cycling protocols, and everything in between.

For research and entertainment purposes only.

0:00 — Intro & How Hunter Organizes Q&A Questions1:21 — Email List & Axion Collective2:17 — Category: Women's Health & Hormones2:21 — Kisspeptin Added to TRT — Does It Help Libido & Muscle for Women?3:43 — Free Testosterone Doubled on GHK-Cu But Feeling Nothing — Reduce HRT?4:39 — What Are Truly Optimal Estrogen & Testosterone Levels for Women?5:58 — Peptides for Women Focused on Health Optimization & Longevity6:41 — Deep Dive on PCOS for Women in Their Late Teens & Early Twenties7:44 — Can Peptides Help Bring Up a Low White Blood Cell Count?8:18 — No-Sting Reconstitution Water & GHK-Cu — Buccal Strips vs Injections11:03 — Category: Men's Health11:03 — Vasectomy Impact on Men's Health & Bioregulators Before & After12:05 — Hit a Plateau on Testosterone — What to Look at Next?12:28 — Best Peptides for Post Cycle Therapy13:33 — PEG-MGF for Real World Use as a Healing Peptide14:41 — Category: Specific Disease States14:50 — Peptide Protocol for Hepatitis C15:23 — Peptides That Help With High Blood Pressure16:28 — Myelin Regeneration & Protection for MS17:10 — FND Diagnosis After Ischemic Stroke — What Peptides Might Help?17:58 — Kidney Transplant & Anti-Rejection Meds — Peptides Worth Exploring?18:57 — Dihexa for Alzheimer's Protocols & Stacks19:35 — Urolithin A & P-21 for an 87-Year-Old With Neurodegenerative Issues20:25 — Amidated vs Non-Amidated P-21 — Does It Matter & How to Dose?21:27 — Does Retatrutide Count Toward the 15mg Weekly Tirzepatide Max?22:17 — Is Metformin Still the Best Longevity Compound?23:10 — Category: Performance & Mitochondrial Health23:15 — Are There People Who Don't Respond to MOTS-C?24:31 — L-Carnitine Timing Around Thyroid Meds & Does Glutathione Cause Gray Hair?25:53 — Had Great Results on 250mcg SLU — Go Higher or Diminishing Returns?26:51 — BAM-15 & SLU Dosing, Cycling & Peptide Refrigeration Shelf Life28:22 — Category: Growth Hormone Peptides28:30 — Optimal Tesamorelin Dose for Non-HIV Use, Stacking With Ipamorelin & Storage30:59 — MK-677 Deep Dive — Using It on Breaks From CJC & Ipamorelin32:05 — Anaphylactic Reactions to Sermorelin After a Year of Use — What Causes This?33:38 — GHK & AHK for Hair Loss, Gray Hair Reversal & Skincare34:32 — Category: Stacking Protocols34:38 — Guidelines for Introducing & Stacking Peptides — Protocol or Symptom Based?36:01 — SLU-PP-332 Pills vs Injection — Which Is Better?36:24 — Best Practice for Reconstituting Ara-290 for Chronic Neuropathy37:20 — Could Thymosin Alpha-1 Trigger a Negative Immune Response & Spike CRP?38:33 — Yearly Bioregulator Cycling Protocol Document40:51 — Closing Thoughts & Thank You

👇 ALL MY LINKS IN ONE PLACE

https://hunterwilliamshealth.com/links

Hunter and Taylor are back for another Reader Mailbag — six questions, real answers, no shortcuts.

This week: building a peptide protocol for autoimmune disease in women, Hunter and Taylor's personal fertility journey on TRT, how to think about peptides and cancer risk, optimizing health for seniors stuck on statins, muscle preservation for perimenopausal women on GLPs, and everything you need to know about reconstitution, mixing peptides, and nasal sprays.

Submit your questions for the next episode at the link in the show notes.

For research and entertainment purposes only.

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In today's episode, we're taking a detour from our usual peptide discussions to dive into one of my absolute favorite biohacking devices: the carbon dioxide therapy inhaler from CarboGenetics. I know what you're thinking—why would we want to inhale CO2 when we usually focus on getting more oxygen? It all comes down to a fascinating physiological mechanism called the Bohr effect. I'll break down the science of how inhaling small amounts of carbon dioxide actually forces your hemoglobin to release more oxygen into your tissues, significantly boosting cerebral blood flow, accelerating wound healing, and enhancing exercise performance. 

We'll explore the history of CO2 therapy, from ancient volcanic vents to modern clinical studies showing impressive results in tumor oxygenation and hearing recovery. I'll also share my personal routine for using the device, including the optimal concentrations and timing for morning wakefulness, pre-workout endurance, and afternoon brain energy. Whether you're a hard-charging entrepreneur looking to regulate your nervous system or an athlete wanting an edge in the gym, this affordable biohack might just be the missing piece in your wellness routine. Tune in to learn how to harness the power of the carbonated body!

Buy Carbogenetics Here(code HUNTERW for 15% off): https://carbogenetics.com/co2inhaler/

The Carbonated Body Book: https://thecarbonatedbody.com/

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