Over the human lifespan, our cells encounter numerous stressors that can trigger an intrinsic defense mechanism called cellular senescence. Cellular senescence is characterized by irreversible growth arrest and can act as a safeguard against cancer. However, when senescent cells accumulate in various tissues as we age, it can contribute to tissue degeneration and chronic diseases.

The senescence-associated secretory phenotype (SASP), a hallmark of senescent cells, plays a critical role by secreting inflammatory factors, proteases, and growth factors, disrupting tissue balance and fueling pathological conditions. Consequently, selectively eliminating senescent cells has emerged as a promising therapeutic strategy, potentially restoring tissue function and mitigating age-related disorders.

Full blog - https://aging-us.org/2024/07/links-between-exercise-senescence-and-lung-health/

Research Paper DOI - https://doi.org/10.18632/aging.205976

Corresponding author - Masataka Sugimoto - [email protected]

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Keywords - aging, senescence, exercise, PEDF, myokine, COPD

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