In this episode of SurgOnc Today, Dr. Julie Hallet and Dr. Patricio Polanco, Chair and Vice-Chair of the SSO HPB Disease Site Working Group review key updates and takeaways from the recent AHPBA Annual Meeting held in March 2025 in Miami. They are joined by Dr. Ryan Ellis and Dr. Michael Lidsky to review clinical trials on locally advanced pancreas cancer, hepatic artery infusion pump, colorectal liver metastases, and pancreas neuroendocrine tumors.