What will it take for No. 5 Michigan to defeat No. 14 Penn State? The game might be at home, and the Nittany Lions may have already lost two games, but are they formidable or more like Wisconsin and Michigan State? 

We give our three keys to the game, go through our Vegas-style over/under picks and pick against the spread, and give our final thoughts on both teams and how we expect the game to go, including our final score prediction.

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