Harriet Jane Lawrence was one of the first female pathologists in the U.S. In the early 1900s she worked in Portland, Oregon, where she hunted microbes and developed vaccines and serum therapies with the help of 200 guinea pigs that she kept in her garage. Her work on a vaccine during the 1918 influenza pandemic earned her presidential recognition and has had a lasting impact on medicine.

Known as “America’s first female cryptanalyst,” Elizebeth Smith Friedman was a master codebreaker who played a pivotal role in both world wars, but for many years, no one knew what she had done—not even her own family.

Elizebeth didn’t set out to be a codebreaker. In 1917, she was a 23-year-old English lit major, looking for an interesting job. That all changed when an eccentric millionaire whisked her off to his lavish country estate and recruited her to work on his passion project: finding the secret codes in Shakespeare’s plays. Elizabeth scoured the texts alongside a tiny team of self-taught codebreakers. No hidden messages surfaced. But soon, the U.S. government came knocking with a slightly higher priority mission. Perhaps her greatest coup was when she uncovered a Nazi spy ring in North America during World War II. J. Edgar Hoover took credit on behalf of the FBI, while Friedman signed an NDA, never speaking of her achievements, and fell into obscurity. Records of what she had done were found in the National Archives annex in College Park, Maryland.

Christine Essenberg had an unusual life and an unusual career trajectory. She was married, then divorced, and earned her PhD in zoology from University of California, Berkeley at age 41. She went on to become one of the early researchers at what is now The Scripps Institution of Oceanography. We know the story of Christine Essenberg only because of a serendipitous find. Host Katie Hafner, searching in an archive jammed with the papers of male scientists, came across a slim folder, "Folder 29", in the back of a box at UC San Diego Special Collections & Archives. Just eight pages as a jumping-off point to flesh out a life, which raises the question: How many other unknown women scientists are out there, hidden away in boxes? This is the story of Christine Essenberg's own journey from researcher to teacher. It’s the first discovery of what we’re calling The Folder 29 Project, a research initiative to uncover the work of lost women of science, hidden in the archives of universities across the country.

Born in 1850, Sarah Loguen found her calling as a child, when she helped her parents and Harriet Tubman bandage the leg of an injured person escaping slavery. When the Civil War ended and Reconstruction opened up opportunities for African Americans, Loguen became one of the first Black women to earn a medical license. But quickly, racist Jim Crow laws prevailed. At the urging of family friend Frederick Douglass, Loguen married and, with her new husband, set sail for the Dominican Republic where more was possible for a person of color. This is her story. 

In the late 1920s, Lillian Gilbreth enlisted her children — she had 11— in an experiment: bake a strawberry shortcake in record time. Kitchens at the time tended to have haphazard configurations—pots and pans could be at one end of the kitchen, the stove in another, and the utensils in another room altogether—but Lillian figured that with a well-designed kitchen, she could slash baking time dramatically and make cooks’ lives easier. And if anyone was going to hack the kitchen, Lillian Gilbreth was the woman for the job.

Lillian and her late husband, Frank, were absolute fiends for efficiency. They’d used the study of “time and motion” to dissect the activities of factory and office workers, and had made a business of optimizing efficiency in the workplace. Now widowed, Lillian Gilbreth, was set to tackle efficiency in the home when their clients would continue working with her and the business failed. Her innovations—she’s widely credited with inventing the pedal trash can and refrigerator door shelves—live with us to this day.

We continue the story of Jewish physicist Lise Meitner, the first person to understand that the atom had been split. This is the second in a two-part series featuring new letters from and to Lise Meitner translated by author Marissa Moss, author of The Woman who Split the Atom: The Life of Lise Meitner (2022). The letters show the fraught and complex relationship between Otto Hahn and Meitner and the role that antisemitism played in the decision to give the Nobel Prize in 1944 to Hahn and not Meitner.

After the discovery of nuclear fission, Meitner grappled with its implication: the advent of nuclear weapons and who would get credit for the discovery of nuclear fission. This would lead to a breakdown of Meitner and Hahn’s decades-long scientific collaboration. Meitner, who had fled Germany because of the Nazis, was horrified at the thought of an atomic bomb. She also faulted Hahn for not speaking out about Nazi atrocities, and questioned his character, though she remained loyal to him to the end. It was their working relationship that defined her life.

New translations of hundreds of letters explain, in a two-part episode of Lost Women of Science, why physicist Lise Meitner was not awarded the Nobel Prize in 1944 for splitting the atom. Instead, it was given to her long-time collaborator, chemist Otto Hahn.

Lise Meitner was born in Vienna in November of 1878 and moved to Berlin before the first World War where she started work with Hahn. When Marissa Moss came to research her biography of Meitner, The Woman who Split the Atom: The Life of Lise Meitner (2022), she found thousands of her letters in the Cambridge University archive, many of which had never been translated.

In this episode we're diving into one particularly illuminating aspect of Meitner's story: her letters with Hahn, which reveal not only that it was Meitner who discovered nuclear fission, when she interpreted experiments that Hahn could not understand, but also her fraught relationship with Hahn. She went to great lengths through her letters to understand his refusal to give her credit for her work before and after the 1944 Nobel Prize was awarded. This first episode takes us up to the end of World War Two.

In the early 1990s, two physicists, Ruth Howes and Caroline Herzenberg, began looking into a question that had aroused their curiosity: Just who were the female scientists who worked on the Manhattan Project?

Nearly ten years and hundreds of interviews later, they documented hundreds of women across a broad spectrum of scientific fields — physics, chemistry, biology, mathematics — who played crucial roles in the top-secret race to build a nuclear weapon that would end World War II.

Since the film Oppenheimer came out earlier this summer, Their Day in the Sun: Women of the Manhattan Project has enjoyed a revival of sorts as new attention is paid to the women for whom recognition is long overdue.

Katharine “Kay” Way was a nuclear physicist who worked at multiple Manhattan Project sites. She was an expert in radioactive decay. But after the atomic bombs were dropped on Japan, she became increasingly concerned about the ethics of the nuclear weapons. Dr. Way signed the Szilard Petition and  worked to spread awareness of the moral responsibility surrounding atomic weaponry, including co-editing the influential One World or None: a Report to the Public on the Full Meaning of the Atomic Bomb, remaining an outspoken advocate for fairness and justice.

Lilli Hornig was only 23 years old when she arrived at Los Alamos to contribute to the development of an atomic bomb that would end World War II. A talented chemist, Lilli battled sexism throughout her career and remained a steadfast advocate for female scientists like herself.

Lilli is the only female scientist named in Christopher Nolan’s film Oppenheimer. But the character is a blur, popping up here and there to say they didn’t teach typing in her graduate chemistry program at Harvard, when asked whether she could be a typist, or to rib a colleague, telling him that her reproductive system was better protected from radiation than his. The real Hornig worked closely on plutonium research and was part of the team that developed and tested the mechanism for the plutonium weapon in the Trinity test.