The management of locally advanced extremity soft tissue sarcomas require a multidisciplinary approach. Surgery remains the standard of care for cure, however, other loco-regional treatments including radiation and isolated limb perfusion as well as systemic treatments have been utilized to reduce local and distant recurrence risk. In this podcast, we will focus on the multidisciplinary approach for locally advanced extremity sarcomas. We will highlight the role of limb-sparing resections versus amputations.