Pearl Jam frontman Eddie Vedder joins the guys to reflect on the early Seattle grunge scene, his first Saturday Night Live appearance in 1991 with David Spade, and how he pulled off the unheard-of feat of performing three songs in one night. He draws surprising parallels between music and stand-up comedy before diving into his new Netflix documentary on epidermolysis bullosa, Matter of Time. The conversation wraps with stories about his “cameo” in Hugh Jackman’s Song Sung Blue and how Martin Short once convinced him to quit smoking.

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