Mark Ruffalo and Woody Harrelson join this week to reminisce about their misadventures in New Orleans! Mark also talks to Ted and Woody about overcoming the tragic death of his best friend, high school theater memories, how he literally fleshed out his character in the hit HBO Max show “Task,” the importance of speaking out against injustice, and more. 

This episode contains a brief discussion of suicide. If you or someone you know needs support now, call or text 988 or chat 988lifeline.org.

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The Emmy-nominated Kathryn Hahn (The Studio, Wanda Vision, Transparent) talks to Ted about why she didn’t expect a career in comedy, her early years doing theater in Cleveland, spirituality, her view of the end of life, retirement goals, and more! 

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Chelsea Handler got where she is by trusting her gut. The comedian, bestselling author, and podcaster talks to Ted Danson about how she feels at 50, the time Jane Fonda called her out, what she loves about writing books, the importance of not selling out, and her thoughts about finding a life companion.

Chelsea will be performing all over the U.S. on her High and Mighty Tour which begins February 2026. Dates can be found on ChelseaHandler.com.

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Ted Danson and his old friend Howie Mandel are covering all the bases this week, from health concerns to personal finance! Howie shares about the origins of his glove bit, how comedy gave him a sense of belonging, his investments in new tech, and how his judging on “America’s Got Talent” has evolved over the years.

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Patton Oswalt has a certain fearlessness, whether he’s doing standup for a sellout crowd or speaking his mind about what he sees in the world. He talks with Ted Danson about the role of comedy in dark times, why he loved Ted in “Body Heat” and “Damages,” his worries for the next generation, and what’s been giving him hope lately.

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Listen to this episode to find out how Rob Reiner made Ted Danson cry! The legendary director and writer talks with Ted about the little-known origins of Spinal Tap, the long-awaited sequel, learning the ropes from his father Carl Reiner, how “Stand by Me” changed his career arc, meeting his wife on the set of “When Harry Met Sally,” and how he became politically engaged.

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Ted Danson is grateful for any chance to reconnect with his dear friend, actor Kate Mara. Kate talks with Ted about the correct pronunciation of her last name, what it was like acting with her sister Rooney in a Werner Herzog film, growing up in an NFL family, how she and her husband Jamie Bell got together, and more. 

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Ted Danson catches up with his pandemic buddy, the fantastic actor Tony Hale. Tony talks with Ted about his “Arrested Development” break, co-starring with D’Arcy Carden in the new film “Sketch,” his unique character type, dealing with anxiety on stage, what faith means to him, and more.

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Actor, writer, and director Charlie Day talks with Ted Danson about the process of creating “It’s Always Sunny in Philadelphia,” why he sometimes goes by “Charlie Trombone,” overcoming typecasting, meeting his wife Mary Elizabeth Ellis, his relationship with Guillermo del Toro, and working with Ethan Coen on the new film “Honey Don’t!”

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Judd Apatow has spent his life obsessed with the sweet science of being funny. He joins Ted Danson to talk about his upcoming book, working with Garry Shandling and Rip Torn, documenting the lives of his comedy heroes, executive producing “Freaks and Geeks,” and what it feels like coming up on the 20th anniversary of "The 40-Year-Old Virgin.”

 

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