In this episode, we review the key maternal infections that can occur during pregnancy, focusing on prevention, early detection, and appropriate treatment to protect both mother and fetus. Based on ATI Chapter 8, we’ll cover screening recommendations and clinical management for infections like HIV, syphilis, gonorrhea, chlamydia, hepatitis, and Group B strep, as well as TORCH infections, trichomoniasis, bacterial vaginosis, candidiasis, and COVID-19. We break down risk factors, signs and symptoms, diagnostic testing, and treatment options—emphasizing which medications are safe during pregnancy. This is a critical review for exam prep, clinical safety, and patient education.