Matthew Alper presents his theory that religious experience and belief in God originate from specific brain structures and neurological functions. Alper discusses evidence that the brain evolved mechanisms generating spiritual experiences for evolutionary survival advantages. The conversation explores neuroscience research identifying brain regions activated during religious experiences, meditation, and prayer. Alper examines universal patterns in religious belief across cultures suggesting hardwired neurological origins rather than divine revelation. The discussion addresses the controversial implications of this materialist explanation for spirituality and whether it invalidates religious truth claims. Alper explores why natural selection might favor individuals and groups with strong religious beliefs and experiences. The broadcast examines studies of temporal lobe stimulation producing mystical experiences and near-death phenomena. Alper discusses the relationship between epilepsy, temporal lobe disorders, and heightened religiosity in some individuals. The conversation tackles whether understanding the neurology of spiritual experience enriches or diminishes the meaning people find in religion.