Megaloblast. Now there’s a word you don’t hear every day. The root -blast (from the Greek blastos, meaning germ or bud) may be somewhat familiar since we talk about blast cells (very young hematopoietic precursor cells) in hematology. And megalo- (from the Greek megas, meaning large or great) is also used fairly frequently, as in splenomegaly (enlargement of the spleen). So does “megaloblast” just mean a large, immature cell? We’ll answer this question, and many more, in this discussion of megaloblastic anemia.

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