A long mishnah - on the affect of pigul when it only affects part of the "permitter" - matirin - namely, by burning one part, the rest becomes permitted for consumption. Including a dispute between Rabbi Meir and the sages -- which leads to other areas of dispute between them. And further, a dispute between Rav and Shmuel about the dispute of Rabbi Meir and the sages. Also, the 43 (or 47 or 48) presentations of blood from the animal sacrifices of Yom Kippur. Also, a sesame seed and the smallest amount of potential pigul. Plus, a rejection of Rabbi Meir's views here.