This podcast covers the essential role of glucose as an energy source for several tissues. Most notably, red blood cells and the brain. Red blood cells are entirely dependent on glucose for their energy needs while the brain is highly dependent on glucose for its energy. Glucose in the bloodstream is produced by the liver and maintained around 80-100mg/dl during fasting to provide red blood cells and the brain with their energy needs.

This podcast covers the four different classes of receptors that illicit intracellular signals, including steroid receptors, ion channel receptors, receptor enzymes, and G-protein coupled receptors.

This episode summarizes the key effects on carbohydrate and lipid metabolism, including the processes that are activated by insulin and the ones inhibited by it.

This podcast describes 4 distinct types of enzyme inhibitors and their mechanism of inhibition, including: substrate analogues, toxins, allosteric inhibitors, and heavy metals.

This podcast covers the regulation of pyruvate kinase allosterically and by hormone-dependent (insulin & glucagon) covalent modification.

This podcast covers the metabolic changes in various organs and key organ uses of the available nutrients in the bloodstream.

With the exception of ketone bodies, the brain is entirely dependent on glucose as an energy source under most circumstances. Glucose is oxidized all the way to CO2 by the brain, producing up to 38 ATPs. This catabolism is dependent on oxygen, which is used to convert the energy in NADH and FADH2 to ATP through the Electron Transport Chain and Oxidative Phosphorylation.

This podcast covers the digestion of the major dietary fat, triacylglycerol, including digestion uptake into intestinal mucosa, delivery through the bloodstream, uptake and storage of fatty acids from chylomicrons in the bloodstream.

This podcast describes the transport of ammonia produced in peripheral tissues by incorporating it into glutamine through glutamine synthase. Glutamine is transported in the bloodstream to either the liver or kidney for further metabolism.