Professor Charles Brenner challenges the NAD decline myth and reveals why nicotinamide riboside (NR) works for metabolic stress, not aging. Learn about the Northwestern trial showing NR improved walking speed in peripheral artery disease while metformin failed, eight clinical trials proving anti-inflammatory effects, and why popular biomarker tests are measuring the wrong thing.

In this conversation, Dr. Charles Brenner, professor at City of Hope and discoverer of nicotinamide riboside's therapeutic uses, challenges common assumptions about NAD and aging. He explains why blood NAD stays stable throughout life and how metabolic stress - not aging - depletes the NAD system.

Dr. Brenner discusses Northwestern University's landmark peripheral artery disease trial where NR improved walking speed while placebo patients declined, why metformin failed the same test, and the eight randomized clinical trials showing NR's anti-inflammatory effects. We explore COVID-19's impact on NAD, why NMN may cause neurodegeneration, optimal NR dosing (300mg-1g daily), and bioavailability questions.

He dismantles the biological age testing industry with evidence showing DNA methylation tests measure inflammation, not aging. Learn why Kaiser Permanente ignores trendy biomarkers, which supplements lack safety data, and the evidence-based approach to NAD supplementation for conditions like wound healing, heart failure, and Parkinson's disease.

🌐Links in this video

Dr Brenner's home page https://www.cityofhope.org/research/find-a-scientist/charles-brenner

X (Twitter) https://x.com/CharlesMBrenner/

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

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Could a decline in "plasmalogens" be a missing link in Alzheimer's and aging? Dr. Peter Meikle reveals why this critical brain lipid drops as we age and the surprising foods that might help restore it.

In this interview, we sit down with Dr. Peter Meikle, Head of the Metabolomics Laboratory at the Baker Heart and Diabetes Institute, to explore the critical role of plasmalogens in human health. Plasmalogens are unique phospholipids that act as powerful antioxidants, protecting our cell membranes from oxidative stress. Dr. Meikle explains how plasmalogen levels naturally decline with age and why this drop is strongly associated with Alzheimer's disease, heart disease, and fatty liver.

We dive deep into the genetic connection, specifically how the ApoE4 gene impacts these lipids, and discuss the results of mediation analyses that suggest a causal link to neurodegeneration. Finally, Dr. Meikle shares practical advice on how to boost your levels, debating the trade-offs of dietary sources like eggs and red meat versus supplements like krill oil and shark liver oil, and outlines the future of synthetic plasmalogen therapy.

🌐Links in this video

Dr Meikle's page at Baker https://baker.edu.au/research/staff/peter-meikle

Pelagic AI https://pelagicai.it/

Juvanescence https://juvlabs.com

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Genetics professor Dr. Jan Vijg explains how DNA damage causes aging and why human lifespan may be limited to 115 years. Learn about the 100,000 DNA hits your cells take daily, breakthrough research on the DREAM gene complex that could slow mutation accumulation, and whether we can extend maximum lifespan.

In this conversation, Dr. Jan Vijg, Professor and Chair of Genetics at Albert Einstein College of Medicine, explains how genome instability drives the aging process. We explore how your cells sustain 100,000 DNA lesions daily, the difference between DNA damage and somatic mutations, and why mutations accumulate exponentially with age.

Dr. Vijg discusses his controversial 2016 Nature paper arguing human maximum lifespan is capped at 115 years, and why mean lifespan improvements don't translate to breaking this limit. He shares exciting new research on the DREAM gene complex - a potential master regulator that could enhance DNA repair across multiple pathways simultaneously.

Key topics include: how DNA repair systems decline with age, why long-lived species have better repair mechanisms, tissue-specific mutation rates, the role of SIRT6 and NAD in DNA repair, rare genetic variants in centenarians, and whether pharmacological interventions could slow aging at the cellular level.

🌐Links in this video

Dr Vijg's page at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/11318/jan-vijg

Evidence for a limit to human lifespan https://pubmed.ncbi.nlm.nih.gov/27706136/

The DREAM complex links somatic mutation, lifespan, and disease https://www.biorxiv.org/content/10.1101/2025.09.15.676396v1.full

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Holistic dentist Dr. Namrata Patel reveals how your oral microbiome predicts heart disease, Alzheimer's, and cancer 10-13 years before symptoms appear. Learn about saliva testing, the bacteria that cause systemic inflammation, why tongue exercises reduce sleep apnea 30%, and the daily protocol that protects your healthspan.

In this conversation, holistic dentist Dr. Namrata Patel explains how your mouth is an early warning system for chronic disease. We explore the specific bacteria that cause heart attacks, diabetes, cancer, and Alzheimer's - and how saliva testing can detect these risks years before blood tests show problems.

Dr. Patel shares breakthrough research on myofunctional therapy, showing how simple tongue exercises can reduce sleep apnea by 30%. We discuss the connection between dry mouth, nitric oxide production, and systemic inflammation, plus why conventional mouthwash may be destroying beneficial bacteria.

Key topics include: the optimal daily oral care protocol, how to monitor your oral health at home, the truth about root canals and hidden infections, when to see a functional dentist versus conventional dentist, and why oral health becomes more critical after age 40. Whether you have perfect teeth or chronic health conditions, this episode reveals how your mouth impacts your longevity.

🌐Links in this video

Green Dentistry Home Page https://sfgreendentist.com/

Dr Patel's book on Amazon:

Age With Style: Your Guide To A Youthful Smile & Healthy Living https://amzn.to/49AdQn5

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Clinical psychologist Dr. Lloyd Glauberman reveals why smart, motivated people struggle to maintain healthy habits - and the 3 things you knew as an infant that could transform your health. Learn about lifestyle intelligence, the metabolism changes after 40, and why sustaining change is harder than starting.

In this conversation, clinical psychologist Dr. Lloyd Glauberman explains the hidden psychological barriers preventing lasting health changes. We explore how family and culture "hypnotically" program us away from natural eating, sleeping, and movement patterns we understood as infants.

Dr. Glauberman introduces the concept of Lifestyle Intelligence - managing the three core elements of health: nutrition, sleep, and exercise. He explains why metabolism slows with age, causing 20+ pound weight gain even without behavior changes, and shares practical strategies for sustaining lifestyle modifications long-term.

Key topics include: the role of sleep as the "lynchpin" for health, why perfectionism sabotages progress, how digital devices create modern trance states, and the surprising calculation showing how every meal adds or subtracts time from your life. Whether you're struggling to start or maintain health changes, this episode provides actionable psychological insights for lasting transformation.

🌐Links in this video

Lifestyle Intelligence website https://lifestyleintelligencelq.com/

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Duke Professor reveals how 90-year-olds tripled their muscle strength in just 10 weeks - and why we've been measuring muscle mass wrong for decades. Dr. William Evans explains the revolutionary new test that predicts disability, mortality, and even Alzheimer's risk. Learn the exact protocols for maintaining muscle mass as you age, the truth about protein requirements, and why your doctor isn't testing for sarcopenia. Plus: critical warnings about GLP-1 weight loss drugs and muscle loss in older adults.

Dr. William Evans is a professor of medicine at Duke University whose pioneering research established sarcopenia as a recognized medical condition. In this episode, he reveals groundbreaking findings about muscle mass and aging that challenge decades of scientific assumptions.

Dr. Evans explains why traditional methods like DEXA scans have been measuring the wrong thing, and introduces his revolutionary creatine-based test that accurately measures muscle mass with just a single urine sample. His research on over 4,000 people proves that muscle mass is central to how we age - affecting everything from physical disability to cognitive function and mortality risk.

We discuss practical strategies for maintaining muscle, including resistance training protocols, optimal protein intake for older adults, and the concerning effects of GLP-1 weight loss drugs on muscle preservation. Dr. Evans also shares insights on hormone therapy, the future of muscle-building drugs, and why exercise remains the single most important intervention for healthy aging and Alzheimer's prevention.

🌐Links in this video

Dr Evans page at Duke University https://medicine.duke.edu/profile/william-joseph-evans

Short Physical Performance Battery https://www.physio-pedia.com/Short_Physical_Performance_Battery

MyoCorp website https://myocorps.com/

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

44% of supplements FAIL testing! Dr. Glenn, Head of Science at SuppCo, reveals which supplements don't contain what they say, how to spot red flags, and why even expensive brands might be lying about what's in the bottle. Learn the 3 essential rules before buying ANY supplement.

Think your supplements contain what they claim? Think again. Dr. Glenn, Head of Science at SuppCo, drops a bombshell: 44% of supplements they've tested have failed - meaning they contain less than 95% of the active ingredient listed on the label. Many have ZERO active ingredients at all.

In this eye-opening interview, Dr. Glenn exposes the dark side of the $70 billion supplement industry, including creatine gummies on Amazon with no creatine, urolithin A products with less than 1% of the active ingredient, and why products with better reviews often contain nothing at all.

Learn which certifications actually matter (NSF, USP, cGMP), the red flags to watch for when shopping, why gummies are particularly risky, and how SuppCo's trust score system helps consumers navigate the overwhelming world of supplements. Plus, get Dr. Glenn's 3 essential tips every supplement buyer needs to know before making their next purchase.

🌐Links in this video

SuppCo website : https://supp.co/home/today

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Methylene blue was the first synthetic medicine ever created. 140 years later, we're discovering it might be one of the most powerful tools for brain health and longevity. Here's what the research actually shows.

Dr. Francisco Gonzalez-Lima has spent decades researching methylene blue, the first synthetic medicine in history. In this conversation, he explains how this unique compound enhances mitochondrial function, increases cellular energy production, and reduces oxidative stress; all at very low doses.

We discuss the critical importance of dose (low dose benefits, high dose harms), why pharmaceutical-grade purity matters, and how to personalize your dosing using a simple urine test. Dr. Gonzalez-Lima also addresses common misconceptions from failed Alzheimer's trials and explains why those studies used the wrong approach.

Looking ahead, he shares his plans to combine methylene blue with near-infrared light therapy and MCT oil for his upcoming clinical trial on mild cognitive impairment. Whether you're interested in cognitive enhancement, neuroprotection, or healthy aging, this is essential viewing.

🌐Links in this video

Dr Gonzalez-Lima's page https://liberalarts.utexas.edu/psychology/faculty/fg

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Hearing loss isn't just about your ears—it's about your brain. Dr. Ben Thompson reveals how treating hearing loss can reduce cognitive decline by 48% and shares breakthrough protocols for tinnitus recovery that actually work.

Audiologist Dr. Ben Thompson explains the critical connection between hearing health and cognitive function, discussing the landmark ACHIEVE study that showed hearing treatment reduced cognitive decline by 48% in at-risk older adults.

Learn how the ear and brain work together, what causes age-related hearing loss, and why the cochlea's hair cells don't regenerate. Dr. Thompson covers the biggest threats to your hearing (hint: it's not just aging), how to protect yourself from noise damage, and the truth about tinnitus, including why most people are told there's nothing they can do when effective treatments exist.

Discover how modern hearing aid technology has evolved beyond bulky devices to sleek, smartphone-integrated systems that actively separate speech from background noise. Whether you're experiencing hearing changes yourself or have aging family members, this conversation offers practical insights on preserving both hearing and cognitive health for the long term.

🌐Links in this video

Treble Health web page: https://treblehealth.com/

Treble Health YouTube Channel https://www.youtube.com/@treblehealth

Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial

https://pubmed.ncbi.nlm.nih.gov/37478886/

The ACHIEVE study page https://www.achievestudy.org/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

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https://www.choosemuse.com

All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

NAD+ Anti-Aging Breakthrough: How This Molecule Could Reverse Aging and Treat Alzheimer's Disease | Clinical Trial Results from Leading Longevity Researcher Dr. Evandro Fang

Some links are affiliate links so we will earn a commission when they are used to purchase products.

Dr. Evandro Fang from the University of Oslo reveals groundbreaking research on NAD+ and its role in combating aging and neurodegenerative diseases. In this interview, Dr. Fang discusses his lab's pioneering work on mitophagy (mitochondrial cleanup) and how NAD+ precursors like NR and NMN have shown remarkable results in clinical trials for premature aging disorders. He shares dramatic case studies, including a 3-year-old Austrian boy who regained motor skills after NAD+ treatment, and explains the molecular mechanisms behind aging at the cellular level. The conversation covers his upcoming Phase 2 clinical trial using Urolithin A for Alzheimer's disease, the challenges of translating longevity research into approved therapies, and combination approaches involving exercise and caloric restriction. Dr. Fang provides practical insights into current NAD+ supplementation evidence while addressing safety concerns and optimal dosing strategies. This technical but accessible discussion offers valuable perspectives on the future of anti-aging medicine and therapeutic interventions for age-related diseases.

🌐Links in this video

Dr Fang's page https://evandrofanglab.com/

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw

https://www.choosemuse.com

All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN

Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)

Renue by Science all 10% discount with code MHS https://renuebyscience.com/

Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan