Dr. Eric Plaisance explains how exogenous ketones may provide fasting benefits without dietary restriction - the hormetic effects of mimicking starvation while fed. Plus: ketone salts vs esters, his personal protocol, and why performance claims don't hold up.

Dr. Eric Plaisance, Associate Professor at University of Alabama Birmingham, has spent over a decade studying exogenous ketone esters. His most intriguing finding? Ketones may allow us to "mimic a starvation environment when we're not starving" - potentially triggering the same hormetic benefits as fasting without dietary restriction. In this conversation, we explore the anti-inflammatory effects of ketones, the promising research in liver health and cancer, and the practical differences between ketone salts, esters, and MCT oil. Dr. Plaisance shares his personal ketone protocol (including why he takes them before workouts during time-restricted eating), optimal dosing strategies, and why the athletic performance marketing claims don't match the research. We also discuss who should actually consider ketone supplementation versus who should save their money. A grounded, evidence-based perspective on one of longevity's most debated supplements.

🌐Links in this video

Dr Plaisance's page at Alabama University https://scholars.uab.edu/2392-eric-plaisance

*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder

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Dr. Mary Newport shares groundbreaking research analyzing cholesterol profiles across 40 years of studies, challenging conventional wisdom about saturated fat and heart health. We discuss her findings on MCT oil for brain health, the 288 caregiver reports showing cognitive improvements, and practical protocols for using coconut oil and ketones.

Dr. Mary Newport, physician and Alzheimer's researcher, joins us to discuss her latest research that challenges decades of assumptions about coconut oil and saturated fat. In this interview, we explore: • Her comprehensive analysis of 26 studies spanning 40 years (984 lipid profiles) showing coconut oil's unexpected effects on cholesterol • The 288 caregiver reports documenting improvements in memory, cognition, and daily function • How medium-chain triglycerides (MCTs) may provide an alternative fuel source for aging brains • Practical protocols for incorporating coconut oil and MCT oil into your diet • The controversial history of dietary fat guidelines and the trans fat problem • Why the medical establishment has been slow to acknowledge ketone research Dr. Newport's work began with her husband Steve's dramatic response to coconut oil after his early-onset Alzheimer's diagnosis. Her research has since expanded to include hundreds of case reports and comprehensive lipid analysis.

🌐Links in this video

🔗 Dr. Newport's website: https://coconutketones.com/ Coalition for Metabolic Health https://coalitionformetabolichealth.org/ Analysis of 26 Studies of the Impact of Coconut Oil on Lipid Parameters: Beyond Total and LDL Cholesterol https://www.mdpi.com/2072-6643/17/3/514 Ketogenic strategies for Alzheimer’s disease and other memory impairments: History, rationale, and 288 caregiver case reports https://esmed.org/MRA/mra/article/view/5316

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DESCRIPTION

Leading hairrestoration surgeon Dr. Alan Bauman reveals the science behind hair loss,graying, and the evidence-based treatments that actually work—from medicationsto regenerative therapies.

Dr. Alan Baumanis a board-certified hair restoration physician who has treated over 30,000patients and performed 14,000+ hair transplants in his 28-year career. In thisconversation, we explore the biological mechanisms behind hair loss andgraying, why you can lose 50% of your hair density before noticing it, and thepractical interventions that work.

We discuss theevidence for medications like minoxidil and finasteride, regenerative therapiesincluding PRP and exosomes, low-level laser therapy, and the role of lifestylefactors like nutrition, stress, and sleep. Dr. Bauman explains genetic testingfor hair loss predisposition, the truth about DHT-blocking shampoos, whetherhair coloring damages follicles, and when to consider surgical options.

Key takeaway:"Time equals follicles"—early intervention is critical because oncehair follicles are damaged, reversal becomes increasingly difficult. Whetheryou're experiencing thinning or want to protect your hair long-term, thisepisode provides actionable, science-based strategies.

🌐Links in this video

Bauman Medical website https://www.baumanmedical.com/

LinkedIn https://www.linkedin.com/in/alanjbauman/

Instagram https://www.instagram.com/baumanmedical/

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Dr. Henry Mahncke reveals how an NIH-funded study showed brain training reversed brain aging markers by 10 years, why speed-based training is uniquely effective, and the future of brain health interventions.

Dr. Henry Mahncke, CEO of Posit Science and creator of BrainHQ, discusses the groundbreaking INHANCE study that used PET scans to show brain training can reverse brain aging by 10 years. In this wide-ranging conversation, Dr. Mahncke explains how their adaptive brain training exercises increase acetylcholine—a crucial neurochemical that declines with age and is depleted in Alzheimer's disease. He addresses common criticisms of brain training, explaining why speed and accuracy training is fundamentally different from memorization exercises, and shares surprising insights including why Tom Brady uses brain training. We discuss optimal dosing (30 minutes daily works well), the role of sleep in brain plasticity, supplementation with compounds like phosphatidylcholine, and whether this should be a lifelong practice. Dr. Mahncke makes the case that we're at the beginning of a "brain health revolution" where maintaining cognitive function should be as routine as physical exercise

🌐Links in this video

Brain HQ website https://www.brainhq.com/ The trial on clinical trials https://clinicaltrials.gov/study/NCT04149457 Effects of Computerized Cognitive Training on Vesicular Acetylcholine Transporter Levels using [18F]Fluoroethoxybenzovesamicol Positron Emission Tomography in Healthy Older Adults: Results from the Improving Neurological Health in Aging via Neuroplasticity-based Computerized Exercise (INHANCE) Randomized Clinical Trial https://games.jmir.org/2025/1/e75161

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Dr. John Cramer, 92-year-old nuclear physicist, discusses participating in the first mitochondrial transplant trial for aging and his longevity theory.

Dr. John Cramer is a 92-year-old emeritus professor at the University of Washington who has spent decades researching nuclear physics and quantum mechanics. Now, he's turned his attention to longevity, and he's not just theorizing. Dr. Cramer is participating in Mitrix's groundbreaking mitochondrial transplantation trial, which aims to replace damaged mitochondrial DNA with healthy versions grown in bioreactors.

In this conversation, Dr. Cramer explains why he believes mitochondrial dysfunction is the root cause of aging, not just another hallmark. He discusses how energy depletion cascades into all other aging symptoms, why previous interventions like telomere extension haven't delivered, and what markers will be tracked throughout his trial. He also shares his personal longevity protocol, including rapamycin, senolytics, and hyperbaric oxygen therapy.

This is one of the first detailed discussions of autologous mitochondrial transplantation for aging in humans.

🌐Links in this video

Mitrix Bio website https://mitrix.bio

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Mayo Clinic's Dr. Sundeep Khosler discusses findings from the first major randomized controlled trial of senolytics in humans, revealing why cellular aging varies dramatically between individuals and what this means for longevity interventions.

Dr. Sundeep Khosler, a physician-researcher at the Mayo Clinic, leads some of the first human clinical trials testing senolytics for aging and age-related diseases. In this conversation, he shares critical findings from their 60-person randomized controlled trial that challenge assumptions about how we age at the cellular level.

The study revealed that senescent cell burden varies dramatically between individuals, with significant implications for who might benefit from senolytic interventions. While overall results showed modest improvements in bone formation markers, women with the highest senescent cell burden (measured through blood biomarkers) showed dramatic 60% improvements—suggesting aging interventions may require personalized approaches rather than universal protocols.

Dr. Khosler discusses the development of blood-based biomarkers for measuring senescent cell burden, explains why age 70 appears to be a critical threshold, and addresses the gap between promising animal studies and human translation. He provides evidence-based guidance on what people can do now, explains why he doesn't recommend current senolytics outside clinical trials, and discusses FDA-approved medications that may impact cellular aging as secondary benefits.

This interview offers a balanced, nuanced perspective on where senolytic research actually stands, moving beyond hype to understand both the promise and limitations of targeting senescent cells for healthspan.

🌐Links in this video

Dr Khosla's page at the Mayo Clinic https://www.mayo.edu/research/faculty/khosla-sundeep-m-d/bio-00078126

Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial

https://pubmed.ncbi.nlm.nih.gov/38956196/

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

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Professor Charles Brenner challenges the NAD decline myth and reveals why nicotinamide riboside (NR) works for metabolic stress, not aging. Learn about the Northwestern trial showing NR improved walking speed in peripheral artery disease while metformin failed, eight clinical trials proving anti-inflammatory effects, and why popular biomarker tests are measuring the wrong thing.

In this conversation, Dr. Charles Brenner, professor at City of Hope and discoverer of nicotinamide riboside's therapeutic uses, challenges common assumptions about NAD and aging. He explains why blood NAD stays stable throughout life and how metabolic stress - not aging - depletes the NAD system.

Dr. Brenner discusses Northwestern University's landmark peripheral artery disease trial where NR improved walking speed while placebo patients declined, why metformin failed the same test, and the eight randomized clinical trials showing NR's anti-inflammatory effects. We explore COVID-19's impact on NAD, why NMN may cause neurodegeneration, optimal NR dosing (300mg-1g daily), and bioavailability questions.

He dismantles the biological age testing industry with evidence showing DNA methylation tests measure inflammation, not aging. Learn why Kaiser Permanente ignores trendy biomarkers, which supplements lack safety data, and the evidence-based approach to NAD supplementation for conditions like wound healing, heart failure, and Parkinson's disease.

🌐Links in this video

Dr Brenner's home page https://www.cityofhope.org/research/find-a-scientist/charles-brenner

X (Twitter) https://x.com/CharlesMBrenner/

Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Could a decline in "plasmalogens" be a missing link in Alzheimer's and aging? Dr. Peter Meikle reveals why this critical brain lipid drops as we age and the surprising foods that might help restore it.

In this interview, we sit down with Dr. Peter Meikle, Head of the Metabolomics Laboratory at the Baker Heart and Diabetes Institute, to explore the critical role of plasmalogens in human health. Plasmalogens are unique phospholipids that act as powerful antioxidants, protecting our cell membranes from oxidative stress. Dr. Meikle explains how plasmalogen levels naturally decline with age and why this drop is strongly associated with Alzheimer's disease, heart disease, and fatty liver.

We dive deep into the genetic connection, specifically how the ApoE4 gene impacts these lipids, and discuss the results of mediation analyses that suggest a causal link to neurodegeneration. Finally, Dr. Meikle shares practical advice on how to boost your levels, debating the trade-offs of dietary sources like eggs and red meat versus supplements like krill oil and shark liver oil, and outlines the future of synthetic plasmalogen therapy.

🌐Links in this video

Dr Meikle's page at Baker https://baker.edu.au/research/staff/peter-meikle

Pelagic AI https://pelagicai.it/

Juvanescence https://juvlabs.com

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Genetics professor Dr. Jan Vijg explains how DNA damage causes aging and why human lifespan may be limited to 115 years. Learn about the 100,000 DNA hits your cells take daily, breakthrough research on the DREAM gene complex that could slow mutation accumulation, and whether we can extend maximum lifespan.

In this conversation, Dr. Jan Vijg, Professor and Chair of Genetics at Albert Einstein College of Medicine, explains how genome instability drives the aging process. We explore how your cells sustain 100,000 DNA lesions daily, the difference between DNA damage and somatic mutations, and why mutations accumulate exponentially with age.

Dr. Vijg discusses his controversial 2016 Nature paper arguing human maximum lifespan is capped at 115 years, and why mean lifespan improvements don't translate to breaking this limit. He shares exciting new research on the DREAM gene complex - a potential master regulator that could enhance DNA repair across multiple pathways simultaneously.

Key topics include: how DNA repair systems decline with age, why long-lived species have better repair mechanisms, tissue-specific mutation rates, the role of SIRT6 and NAD in DNA repair, rare genetic variants in centenarians, and whether pharmacological interventions could slow aging at the cellular level.

🌐Links in this video

Dr Vijg's page at Albert Einstein College of Medicine https://einsteinmed.edu/faculty/11318/jan-vijg

Evidence for a limit to human lifespan https://pubmed.ncbi.nlm.nih.gov/27706136/

The DREAM complex links somatic mutation, lifespan, and disease https://www.biorxiv.org/content/10.1101/2025.09.15.676396v1.full

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If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Holistic dentist Dr. Namrata Patel reveals how your oral microbiome predicts heart disease, Alzheimer's, and cancer 10-13 years before symptoms appear. Learn about saliva testing, the bacteria that cause systemic inflammation, why tongue exercises reduce sleep apnea 30%, and the daily protocol that protects your healthspan.

In this conversation, holistic dentist Dr. Namrata Patel explains how your mouth is an early warning system for chronic disease. We explore the specific bacteria that cause heart attacks, diabetes, cancer, and Alzheimer's - and how saliva testing can detect these risks years before blood tests show problems.

Dr. Patel shares breakthrough research on myofunctional therapy, showing how simple tongue exercises can reduce sleep apnea by 30%. We discuss the connection between dry mouth, nitric oxide production, and systemic inflammation, plus why conventional mouthwash may be destroying beneficial bacteria.

Key topics include: the optimal daily oral care protocol, how to monitor your oral health at home, the truth about root canals and hidden infections, when to see a functional dentist versus conventional dentist, and why oral health becomes more critical after age 40. Whether you have perfect teeth or chronic health conditions, this episode reveals how your mouth impacts your longevity.

🌐Links in this video

Green Dentistry Home Page https://sfgreendentist.com/

Dr Patel's book on Amazon:

Age With Style: Your Guide To A Youthful Smile & Healthy Living https://amzn.to/49AdQn5

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Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN

If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan

You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan