In our recent podcast episode with Dr. Petra Cerna, an expert on feline mycobacteria, we delved into various aspects of this intriguing topic. Dr. Cerna, who trained under Dr. Susan Little, shared her profound motto: persist. We explored regional concerns such as mycobacterium avium in the US and mycobacterium bovis in the UK, where deer and rodents serve as reservoirs. Our discussion covered key points on diagnosis and therapeutic approaches for managing these infections in feline populations.