National Institute for Health and Care Research

By NIHRScience

National Institute for Health and Care Research episodes

February 24, 2021 Professor Pam Kearns - The CATALYST trial: Accelerating drug development for COVID-19
Professor Pam Kearns, Director of the Cancer Research UK Clinical Trials Unit, University of Birmingham
The CATALYST trial: Accelerating drug development for COVID-19
Transcript: https://docs.google.com/document/d/1h5c5C15kiTqsPEJPoHXkbcDTD_hbhIBNzSQjQavteLk/edit?usp=sharing
11 min
February 22, 2021 Clinicians in Conversation: Rapid developments in the treatment of Viral Hepatitis
View the accessible transcript of this podcast

In this episode we are talking about viral hepatitis. You will hear from Professor Andrew Ustianowski, NIHR's National Specialty Co-Lead for Infection and Professor William Rosenberg, NIHR's National Specialty Lead for Hepatology. They will be taking a look at how the research environment in the UK has enabled rapid developments in the treatment of viral hepatitis with a particular focus on commercial clinical research.

You can listen to all our full collection of #ComplexInnovativeDesign trial podcasts on our website.

To find out more about how the NIHR supports complex and innovative design trials, visit the NIHR website: www.nihr.ac.uk/innovative-trials
9 min
February 17, 2021 Dr Camille Carroll - The role of digital technology, in clinical trials.
Dr Camille Carroll Associate Professor and Honorary Consultant Neurologist Peninsula Medical School (Faculty of Health). NSL for Neurology NIHR CRN
The role of digital technology, such as sensors and wearables, in clinical trials.
Transcript https://docs.google.com/document/d/1OwnBt7efXXCn3-DpefjIukDHtrrXYzEg9XmzXfhZQoc/edit?usp=sharing
16 min
February 10, 2021 Kirsty Wydenbach Challenges and advice for CID trials, and how COVID-19 has impacted the MHRA.
Dr Kirsty Wydenbach deputy unit manager and senior medical assessor at the clinical trials unit in the MHRA
Challenges and advice for complex innovative design trials, and how COVID-19 has impacted on the MHRAs approach.
Transcript:https://docs.google.com/document/d/1HS-c3mR-B4m3RCtRpWHb5kIS8Xv90XJ2IIReWOg4fpw/edit?usp=sharing
13 min
February 08, 2021 Clinicians in Conversation INTEGRATE UK: Harnessing the power of the UK collaborative research culture
View the accessible transcript of this podcast

In this episode you will hear from the national trainee leads for Ear, Nose and Throat (ENT); Jameel Muzzaffar, Rishi Mandavia and Matthew Smith - who is also the co-founder of the INTEGRATE UK Trainee Network. They explain how using an innovative and efficient way of working, devised in the UK, they are able to help answer key research questions in ENT with minimal resources. They showcase the SEASHELL study a national multi-center cohort study of patients with sudden onset central hearing loss in the NHS which as recruited over 650 patients at 75 sites with very little funding.

They also about how the NIHR and the INTEGRATE network provides opportunities for trainees to gain vaulable experience in delivering and coordinating clinical research and helps to develop the next generation of ENT researchers.

You can listen to all our full collection of #ComplexInnovativeDesign trial podcasts on our website.

To find out more about how the NIHR supports complex and innovative design trials, visit: www.nihr.ac.uk/innovative-trials
15 min
February 03, 2021 Yan Yiannakou - Running a wholly virtual trial during the COVID-19 pandemic.
Yan Yiannakou Clinical Director of the NIHR Patient Recruitment Centre – Newcastle
Running a wholly virtual trial during the COVID19 pandemic.
Transcript:
https://docs.google.com/document/d/1_HkW3ixWip1XtrqUAGeiinQX7J3divCC1tKo_X_HUWg/edit?usp=sharing
13 min
January 27, 2021 How the COVID-19 pandemic broke the innovation pain barrier
View the accessible transcript of this podcast

Emma Lowe talks to Professor Allan Gaw about how the UK was able to get world-renowned, innovative platforms trials - such as RECOVERY, REMAP-CAP and PRINCIPLE - up and running at record speed in order to rapidly deliver answers about which medicines were effective in treating COVID.

She reflects on how the uptake and acceptance of forward-thinking trial designs and delivery techniques accelerated during the pandemic as innovation went mainstream. She also zooms in on other stand out features such as the flexibility of the regulators, the ingenious use of data to direct and manange research resources, and the shift in mindset which saw decentralised and virtual trials being delivered in peoples homes.

This podcast is part of our 'Persectives from the Pandemic' series looking at the delivery of Complex and Innovative Design (CID) trials in the COVID-19 pandemic. You can access the full series of #ComplexInnovativeDesign trial podcasts on our website: www.nihr.ac.uk/documents/delivering-complex-and-innovative-trials-podcast-collection/29517

To find out more about how the NIHR supports complex and innovative design trials, visit: www.nihr.ac.uk/innovative-trials

You can listen to all our full collection of #ComplexInnovativeDesign trial podcasts on our website.
13 min
January 27, 2021 Emma Lowe - Innovation in clinical research during the COVID pandemic
Emma Lowe - acting head of research policy for clinical research and growth at the UK department of health and social care (DHSC) - focus on the Innovation in delivery of research studies during the COVID pandemic.
Transcript: https://docs.google.com/document/d/13XO3AK7ar2co34e0zT-jPWZ-iI88xavLaqzXo0O09DE/edit?usp=sharing
13 min
January 18, 2021 Trailer - Innovation in Trial Design and Study Delivery during the COVID pandemic Podcast Series II
Following on from our first round of podcasts that evolved from the recommendations in the paper; Effective delivery of Complex Innovative Design (CID) cancer trials- a consensus statement focusing on complex innovative design trials the NIHR CRN coordinating center has again collaborated with the Health Research Authority and in this series, the NIHR Office for Clinical Research Infrastructure. This time, we will be discussing some of the key learning points from the COVID-19 pandemic, such as: -
Has the recent success using innovative design and delivery of research studies during the COVID pandemic been part due to the advance of innovation in trials pre-COVID-19?
Could Continuous Improvement mean innovation in COVID-19 research inform studies post the pandemic? And how can we evidence this?
The general learnings and happenings throughout the COVID-19 pandemic, and we will be building on the further questions around the management and delivery of innovative design trials during the pandemic.
From Weds 27th January we will roll out a weekly podcast here aimed at anyone with an interest in designing, delivering or reviewing Innovation in Trail Design and Study Delivery. They are presented by experienced research professionals from across the research environment.
The research delivery infrastructure in the UK provided by the NIHR, working closely with the NHS, regulators and stakeholders, continues to deliver unparalleled clinical research activity to address the COVID-19 pandemic. Agility, coordination and innovation are core attributes that are driving this impact made by our clinical research. They are also attributes that will ensure the UK can regrow the comprehensive health and social care research portfolio as soon as the harm of the COVID-19 pandemic upon health and social care is overcome. Drawing upon proven research infrastructure and our culture of continuous improvement from recent experience (such as those shared in this podcast series) provides this platform for future success.
2 min
January 06, 2021 The advantages of the adaptive platform trial design
View the accessible transcript of this podcast

Professor David Sebag Montefiore talks to Professor Allan Gaw about the advantages of the adaptive platform trial design.

He zooms in on the PLATO trial (PersonaLising Anal cancer radioTherapy dose) explaining how a traditional approach would have required three separate clinical trial proposals, three separate applications, and three separate trials with three separate teams to manage them. In contrast, the platform approach enabled one research team to answer multiple research questions within one overarching trial platform.

To find out more about how the NIHR supports complex and innovative design trials, visit the NIHR website: www.nihr.ac.uk/innovative-trials

This podcast is part of our pre-pandemic series of podcasts on Complex and Innovative Design (CID) trials. You can listen to all our full collection of #ComplexInnovativeDesign trial podcasts on our website.
19 min

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The National Institute for Health and Care Research (NIHR): funding, enabling and delivering world-class health and care research that transforms people's lives. Visit our website: www.nihr.ac.uk