Compounding evidence from experimental, epidemiological and clinical studies indicate that cerebral amyloid plaque formation, vascular dysfunction and reduced cerebral blood flow (CBF) all play important roles in the cognitive decline associated with aging and aging-related diseases. Recently, hyperbaric oxygen therapy (HBOT) was shown to improve cognitive performance in animal models of Alzheimer’s disease (AD) and in human patients. However, previous research has not directly shown how, or if, HBOT mitigates cerebrovascular dysfunction in AD.

“Therefore, we investigated the effects of HBOT on CBF and cognitive decline in the 5XFAD mouse model of AD that presents aggressive accumulation of amyloid load, cerebrovascular abnormalities and cognitive impairment, as well as in elderly individuals suffering from significant memory loss.”

Researchers from Tel Aviv University and Shamir (Assaf Harofeh) Medical Center conducted a new research study in an effort to better understand the underlying mechanisms of HBOT-mediated effects. They authored a trending research paper, published by Aging (Aging-US) in August 2021, entitled, “Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients.”

Full blog - https://www.impactjournals.com/journals/blog/aging/trending-with-impact-new-hyperbaric-oxygen-hbot-study-breaks-ground/

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203485

DOI - https://doi.org/10.18632/aging.203485

Full text - https://www.aging-us.com/article/203485/text

Correspondence to: Uri Ashery email: [email protected]

Keywords: Alzheimer's disease, hyperbaric oxygen therapy, vascular dysfunction, cerebral blood flow, amyloid burden, aging

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at http://www.Aging-US.com​​ or connect with us on:

Twitter - https://twitter.com/AgingJrnl

Facebook - https://www.facebook.com/AgingUS/

SoundCloud - https://soundcloud.com/aging-us​

YouTube - https://www.youtube.com/agingus​

LinkedIn - https://www.linkedin.com/company/aging​

Aging-US is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​​ or connect with @ImpactJrnls

Media Contact

18009220957