How often did human graders agree with software designed to detect and quantify retinal fluid in wet AMD patients using a home OCT prototype? Moderator Sabin Dang, MD, is joined by panelists Lediana Goduni, MD, and Prethy Rao, MD, MPH, to examine how reliable such software was in a prospective observational study. After the break, the group speculates how these new data may affect retina doctors' comfort with home OCT and asks what is the minimum viable image quality required to trust home OCT imaging.  

Were fluid-free visits correlated with outcomes in the HAWK/HARRIER studies? Moderator Katherine Talcott, MD, and panelists Kyle Kovacs, MD, and Rebecca Soares, MD, MPH, summarize data from a study examining this question, review what it means to be "free of fluid," and discuss how these data fit into the overall conversation about fluid toleration in wet AMD. 

Is a solution to extending duration with aflibercept (Eylea, Regeneron) in DME patients an 8-mg dose rather than the typical 2-mg dose? Diana Do, MD, joined us to review data from the PHOTON study, which assessed the safety and efficacy of high-dose aflibercept in DME patients.

And we hear from Jennifer Lim, MD, who summarized data on extending treatment intervals in the phase 3 YOSEMITE and RHINE studies. Could a significant number of DME patients make it to 12—or even 16—weeks before needing another faricimab (Vabysmo, Genentech/Roche) dose? 

How are doctors using faricimab (Vabysmo, Genentech/Roche) in real-world settings? The IRIS Registry has a few answers. We sat down with Durga Borkar, MD, MMCi, to hear what researchers in the FARETINA-AMD study group found regarding dynamics related to faricimab’s use in wet AMD patients since its approval in January of last year. 

We also interviewed Varun Chaudhary, MD, to learn specifically about faricimab treat-and-extend regimens in wet AMD patients who were enrolled in TENAYA and LUCERNE. How many patients achieved treatment intervals of 12 or 16 weeks? 

After years of failed clinical trials, we finally have an approved therapy for geographic atrophy, and more are hopefully on the way. Allen C. Ho, MD, and Robert L. Avery, MD, sit down with Eleonora M. Lad, MD, PhD; Jeffrey S. Heier, MD; and Dilsher Dhoot, MD, to discuss the introduction of geographic atrophy therapies into the retina clinic.

What did an analysis of the Korean National Health Insurance Service database reveal about the link between age-related macular degeneration and depression risk? Moderator Sabin Dang, MD, is joined by panelists Lediana Goduni, MD, and Prethy Rao, MD, MPH, to summarize the study's findings. After the break, the discussion turns to whether depression screening should (or could) occur in retinal clinics, and how optimistic framing of a diagnosis may make a difference in the lives of patients. 

What does an analysis of the Japan-Retinal Detachment Registry reveal about the relationship between duration of macular detachment and visual prognosis? Moderator Priya Vakharia, MD, invites panelists Sruthi Arepalli, MD, and Vaidehi Dedania, MD, to explore the design and findings of a recent paper by Miyake et al on this topic. After the break, they discuss the clinical and medico-legal implications of the paper’s findings. 

Cynthia A. Toth, MD, and Amani A. Fawzi, MD, sit down with experts Philip J. Rosenfeld, MD, PhD; SriniVas Sadda, MD; and Nadia K. Waheed, MD, MPH, to discuss the value of OCT angiography in the retina clinic. From assessing macular neovascularization to tracking treatment effect in patients with plaque choroidal retinopathies, this imaging modality can augment current tools—and even replace them, at times. Hear their pearls, tips, and tricks for integrating OCT angiography into your clinical routine.  

The FDA approval of pegcetacoplan (Syfovre, Apellis Pharmaceuticals) is a historic moment for the field of retina, finally providing a treatment option for patients with geographic atrophy. Allen C. Ho, MD, and Robert L. Avery, MD, share their initial reactions to the approval and discuss the potential effect on patient care and clinical practice. 

Diversity and inclusion in medical practice is essential, and while retina specialists always have their patients’ and colleagues’ best interests at heart, sometimes that message can get lost in translation, especially when it comes to LGBTQ+ sensitivities. Vivienne S. Hau, MD, PhD, and Basil K. Williams Jr, MD, sat down with four experts—Jessica Weinstein, MD; Roberto Diaz-Rohena, MD; Steven Sanislo, MD; and Brandon Johnson, MD—to discuss ways to foster workplace diversity and inclusion for LGBTQ+ patients and physicians.