In this episode of the Talking Biotech podcast, Dr. Roger Cone discusses the complexities of obesity and eating disorders, emphasizing the role of brain circuits in regulating feeding behaviors. He explains the significance of GLP-1 agonists and melanocortin receptors in developing therapeutic approaches for conditions like obesity, anorexia, and cachexia. The conversation highlights the potential of combining these therapies to enhance treatment efficacy and the implications for public health. But most importantly, the approaches offer potential new therapies to address anorexia and cachexia that may prove to be as effective as GLP1 agonists have been for addressing obesity.