John O’Keefe (City College, 1963) describes his discovery of the brain’s “internal GPS,” which won him a 2014 Nobel Prize, and discusses his formative years as a CUNY undergraduate. The son of Irish immigrants, born in Harlem and raised in the South Bronx, he transferred to CUNY from a private college that he had attended at night while working to support himself during the day. But at CUNY, he could afford the day program with far less time devoted to outside work. Deeply curious, O’Keefe explored philosophy and film courses, among others, graduating with more than 40 credits beyond the requirements of his psychology major.