Back in the 1980s, when Shimon Sakaguchi was a young researcher in immunology, he found it difficult to get his research funded. Now, his pioneering work which explains how our immune system knows when and what to attack, has won him a Nobel prize.

Sakaguchi, along with American researchers Mary Brunkow and Fred Ramsdell, were jointly awarded the 2025 Nobel prize in physiology or medicine for the work on regulatory T-cells, known as T-regs for short, a special class of immune cells which prevent our immune system from attacking our own body.

In this episode Sakaguchi tells The Conversation about his journey of discovery and the potential treatments it could unlock.

This episode was produced by Mend Mariwany, Katie Flood and Gemma Ware. Sound design and mixing by Michelle Macklem and theme music by Neeta Sarl. Read the full credits for this episode and sign up here for a free daily newsletter from The Conversation.

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