Highlights from the March 3rd issue of CMAJ, presented by Dr. Kirsten Patrick, deputy editor, and Dr. Domhnall MacAuley, associate editor. In this issue: seasonal variation of nocturnal leg cramps, concerns over the use of quinine to treat leg cramps, quality indicators of pharmacotherapy, dangers of trimethoprim-sulfamethoxazole co-prescribed with spironolactone, IV immunoglobulin as therapy, human myiasis in Canada, use of primary care EMR data for research, and more. Full issue table of contents: http://www.cmaj.ca/content/187/4.toc