In this episode of HSS Presents, Dr. Mary “Peggy” Crow hosts a compelling discussion with Drs. Kyriakos Kirou and Robert Spiera on cutting-edge cellular therapies transforming the treatment of autoimmune rheumatic diseases. The panel delves into the science and clinical promise of CAR T-cell therapy and bispecific T-cell engagers (BiTEs), exploring how these oncology-derived approaches are being applied to conditions like lupus, scleroderma, myositis, and ANCA-associated vasculitis. They discuss the mechanisms of action, safety considerations, and patient selection, while also highlighting the goal of achieving long-term, drug-free remission through immune system “reset.” This thought-provoking episode offers a glimpse into the future of precision immunology and the evolving role of living cellular therapies in rheumatology.