JACI: In Practice Editor Robert Zeiger describes the October issue, the theme of which is “Preschool Wheezing”. Theme topics covered include risk factors and mechanisms leading to preschool recurrent wheeze and asthma, phenotype-based management of recurrent preschool wheezing and asthma, controversies in the management of preschool asthma, and the impact of social drivers of health on recurrent preschool wheeze. Dr. Zeiger then presents the Highlights of the Original Articles in the issue, which are on the topics of Asthma, Atopic Dermatitis, Drug Allergy, Food Allergy, Inborn Errors of Immunity, Inducible Laryngeal Obstruction, and Rhinitis.