Linda Moulton Howe investigates bioterrorism threats before Chris Ruddy discusses investigative journalism. Howe examines the anthrax letters targeting media and government officials in October 2001. The conversation explores the weaponization of anthrax and the expertise required to produce weapons-grade spores. Howe discusses whether the anthrax attacks connect to September 11th or represent a separate threat. Ruddy examines investigative journalism in the internet age and the changing media landscape. The discussion addresses bioterrorism preparedness and the public health response to anthrax exposure. Howe investigates the origin of the anthrax used in the letters and evidence about the perpetrator. Ruddy discusses his investigative work on various stories and the challenges of finding truth in complex events. The broadcast explores the fear and disruption bioterrorism creates beyond the actual casualties. Howe examines worst-case bioterrorism scenarios and the potential for catastrophic releases of engineered pathogens. The conversation addresses the investigation into who sent the anthrax letters and their motivations.