ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson

Here's a great episode from another show on Kaleidoscope's network, What Could Go Right? 
What happens when our biological need for certainty clashes with an increasingly unpredictable world? Simone Stolzoff, author of How to Not Know, joins host Zachary Karabell to discuss why our modern intolerance for uncertainty is fueling a global anxiety crisis. Rather than seeing the unknown as a threat, Stolzoff argues that uncertainty is the fundamental birthplace of scientific breakthroughs, original art, and human progress.

Stolzoff and Karabell explore how to navigate everything from the climate crisis and the AI revolution to high-stakes parenting and career choices through the framework that the false certainty we cling to might actually be detrimental to our success.

While acknowledging the hard truths of today's world, Stolzoff explains why "action absorbs anxiety" and makes the case for diversifying our identities so we remain adaptable in the face of an unwritten future.

What Could Go Right? is produced by The Progress Network and Kaleidoscope.

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What if someone told you that you could skip years of therapy with a few mental tricks? It sounded impossible… until we found Neuro-Linguistic Programming. NLP is a form of hypnosis beloved by everyone from sex cults to the U.S. military to fortune 500 companies–yet almost no one knows it exists. 

Long before she co-founded NXIVM, hypnotist Nancy Salzman encountered NLP as a radical method for reprogramming the mind. Her story leads us to its inventor, Richard Bandler, a volatile, self-made guru. As we dig into how it took hold in so many places, we face an unsettling possibility: NLP might actually work.

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In the four years since the book’s publication, CRISPR has revolutionized the world of medical treatments and possibilities. But our world has changed drastically, too. As AI’s impact grows, U.S scientists are facing funding cuts like never before. For our final episode, we bring you a live conversation between Walter Isaacson and Jennifer Doudna at the New Orleans Book Festival. In her own words, you’ll hear Doudna explain how CRISPR blossomed from an idea to a phenomenon, and the challenges scientists faces in this politically fraught moment.

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As the gene editing field kept growing, so did the dangers. Back in 2018, Jennifer Doudna received an email from a Chinese scientist claiming that he had genetically edited two twin babies. The news reverberated across the world and made Doudna and her colleagues urgently consider the implications of what their discovery could mean for humanity. 

Walter Isaacson sits down with Evan and tells him why the field has always been ripe with ethical questions, and how the COVID-19 pandemic pushed researchers to recalibrate their priorities.

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Jennifer Doudna thought she had won the race. She thought she had beaten out all scientific competitors when she and her co-author had shocked the world with their groundbreaking technology for gene editing. But turned out, the race had just gotten fiercer. 

Walter Isaacson sits down with Evan to talk about how one of the most cutthroat scientific competitions in biotech got started around one goal — making CRISPR work for humans, and getting the credit for it.

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Back in the 1990s, a young microbiologist in Alicante, Spain became obsessed with a strange pattern he observed in the genes of tiny organisms — a series of inexplicable clusters. And he wasn’t alone. All around the world, a network of scientists were growing curious as to what these genetic knots could be and all of their potential functions. Their curiosity would prove to be the foundation for a history altering discovery: the ability to edit our genetic code.  

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Earlier this year, when the world learned the news of baby KJ successfully undergoing the first personalized genetic treatment, it represented a milestone for researchers and patients. But behind this scientific feat there’s the story of the technology that made it possible, CRISPR, and one of the key pioneers behind it — Jennifer Doudna. 

Evan sits down with Walter Isaacson to understand how Doudna’s upbringing in Hilo, Hawaii influenced her trajectory as a gene editing scientist. And how the history of gene editing might have started with understanding DNA, but soon after, it became clear the real secret lay with its underrated sibling molecule, RNA.

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Walter Isaacson - bestselling biographer behind Musk, Einstein and Steve Jobs - in conversation with Evan Ratliff brings you behind the scenes of The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. The story of the third great technological revolution in modern times.  

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In this final episode of our series, host Evan Ratliff and biographer Walter Isaacson discuss Benjamin Franklin's remarkable late-in-life achievements-- from his last anonymous essay, to the way he empowered George Washington, to his evolution on slavery, to the beautiful way Philadelphia mourned its favorite son... oh, and they discuss Ben Franklin's favorite magic trick, too! 

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After retiring at the age of 42, Ben Franklin immersed himself in politics, taking on enormous diplomatic challenges on behalf of Pennsylvania and the colonies. In this episode, we dive into Franklin the talented statesman-- a man who emerged from his mission in England with a taste for revenge, charmed the French into supporting a burgeoning nation, and somehow found time to get involved in every revolutionary tract-- from Common Sense to the Constitution... in between playing chess in the bathtub!   

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