Ophthalmology Journal

Uveitis is a heterogenous group of inflammatory eye diseases for which current cytokine-targeted immune therapies are effective for only a subset of patients. Dr. Edmund Tsui is joined by Dr. Lynn M. Hassman and MD/PhD student Joseph B. Lin to explore potential common underlying mechanisms that exist for immune cell recruitment in uveitis in their Ophthalmology Science article, "Aqueous macrophages contribute to conserved CCL2 and CXCL10 gradients in uveitis"

Aqueous Macrophages Contribute to Conserved CCL2 and CXCL10 Gradients in Uveitis. Lin, Joseph B. et al. Ophthalmology Science, Volume 4, Issue 4.

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Vitamin A deficiency is the leading cause of preventable childhood blindness worldwide, but how does this deficiency present itself in a clinical setting? Dr. Drew Carey finds out as he interviews Dr. Nieraj Jain, author of "Characteristics of Vitamin A Deficiency Retinopathy at a Tertiary Referral Center in the United States."

Characteristics of Vitamin A Deficiency Retinopathy at a Tertiary Referral Center in the United States. Levine, David A. et al. Ophthalmology Retina, Volume 8, Issue 2, 126 - 136

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An analysis of the IRIS® Registry shows IOL exchanges are increasing over time with vision improving 60% of the time, but worse visual outcomes associated with greater age, worse baseline vision, Black race, Hispanic ethnicity, Medicaid insurance, smoking, and concurrent vitrectomy.

Dr. Matt Feng sits with authors Drs. David F. Chang and Fasika A. Woreta to discuss these findings and more from their Ophthalmology article, "Visual Acuity Outcomes and Complications after Intraocular Lens Exchange: An IRIS® Registry (Intelligent Research in Sight) Analysis."

Visual Acuity Outcomes and Complications after Intraocular Lens Exchange. Son, Hyeck-Soo et al. Ophthalmology, Volume 131, Issue 4, 403 – 411.

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The Department of Health and Human Services, Health Resources and Services Administration's Health Workforce Simulation Model forecasts a sizeable shortage of ophthalmology supply relative to demand by the year 2035, with substantial geographic disparities.

Dr. Edmund Tsui is here with author Dr. Sean T. Berkowitz to breakdown the implications of this shortage from his recent Ophthalmology article, Ophthalmology Workforce Projections in the United States, 2020 to 2035.

Ophthalmology Workforce Projections in the United States, 2020 to 2035. Berkowitz, Sean T. et al. Ophthalmology, Volume 131, Issue 2, 133 – 139.

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Scleral buckling is a common surgical procedure for the repair of rhegmatogenous retinal detachment. The association between scleral buckling and angle-closure glaucoma is well-documented. However,the influence of scleral buckling on the development and progression of open-angle glaucoma is less well understood.

Dr. Lori Provencher interviews Dr. Arthur J. Sit on the effect of scleral buckle surgery on ocular biomechanics and aqueous humor dynamics from his Ophthalmology Glaucoma article, "The Effect of Scleral Buckle Surgery on Tonographic Outflow Facility, Positional Intraocular Pressure, and Ocular Biomechanics."

The Effect of Scleral Buckle Surgery on Tonographic Outflow Facility, Positional Intraocular Pressure, and Ocular Biomechanics. Lyons, Lance J. et al. Ophthalmology Glaucoma, Volume 7, Issue 1, 1 – 7.

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Neuro-ophthalmology consultations are critical to the diagnosis and management in the hospital setting. Prompt consultation prevents diagnostic errors and improves patient outcomes. The scarcity of neuro-ophthalmologists means that the increasing outpatient demand cannot be met, prompting many emergency department referrals by non–neuro-ophthalmologists.

Dr. Drew Carey discusses this shortage of neuro-ophthalmologists and the need for technological and diagnostic aids for greater outpatient access with Dr. Valérie Biousse, author of "Neuro-ophthalmology Emergency Department and Inpatient Consultations at a Large Academic Referral Center."

Neuro-ophthalmology Emergency Department and Inpatient Consultations at a Large Academic Referral Center. Okrent Smolar, Avital Lily et al. Ophthalmology, Volume 130, Issue 12, 1304 – 1312

Syphilis is often known as the "the great masquerader" because it can mimic symptoms and look like a wide array of other diseases. Dr. Edmund Tsui interviews Dr. Michael Huvard to get to the bottom of how acute syphilitic posterior placoid chorioretinopathy presents itself in eyes and the outcomes for these patients, from his Ophthalmology article "Clinical Characteristics and Visual Outcomes of Acute Syphilitic Posterior Placoid Chorioretinopathy"

Clinical Characteristics and Visual Outcomes of Acute Syphilitic Posterior Placoid Chorioretinopathy. Mirzania, Delaram et al. Ophthalmology Retina, Volume 7, Issue 12, 1080 - 1086

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Dr. Drew Carey sits down with Dr. Thomas V. Johnson to discuss the work of the RReSTORe Consortium in the field of regenerative medicine as applied to optic neuropathies from his Ophthalmology Science article, "The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, & Optic Nerve Regeneration (RReSTORe) Consortium."

For more of the Ophthalmology Science special issue on Neuroprotection, Neuroenhancement, and Neuroregeneration visit https://www.ophthalmologyscience.org/xops-vsi-neuroprotection

For more information on the RReSTORe Consortium visit: https://www.johnsonlab.co/rrestore-home/rrestore-main-page/

The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium. Johnson, Thomas V. et al. Ophthalmology Science, Volume 3, Issue 4.

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Endothelial keratoplasty (EK) procedures have become the preferred method of corneal transplantation in the United States. As the frequency of EKs increase, so do associated costs.

Dr. Matt Feng interviews Drs. David S. Portney and Shahzad I. Mian about their recent analysis

to assess for differences in surgical costs and surgery length based on type of EK, use of preloaded grafts, and performance of simultaneous cataract surgery with EK from their Ophthalmology article "Cost Drivers of Endothelial Keratoplasty: A Time-Driven Activity-Based Costing Analysis."

Cost Drivers of Endothelial Keratoplasty. Goldstein, Jenna K. et al. Ophthalmology, Volume 130, Issue 10, 1073 – 1079.

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The Primary Tube Versus Trabeculectomy Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube shunt surgery and trabeculectomy with mitomycin C in eyes without previous ocular surgery. Dr. Lori Provencher sits down with authors Dr. Sara J. Coulon and Dr. Steven J. Gedde to discuss the results of this trial from their Ophthalmology Glaucoma article, "Outcomes of Glaucoma Reoperations in the Primary Tube Versus Trabeculectomy Study."

Outcomes of Glaucoma Reoperations in the Primary Tube Versus Trabeculectomy Study. Coulon, Sara J.Gedde, Steven J. et al. Ophthalmology Glaucoma, Volume 6, Issue 4, 422 – 431.