He was from Adrianopolis in Bythinia, and took up the ascetical life at a young age. After many spiritual struggles he took up residence on a pillar, where he dwelt for fifty-three years. Crowds came to seek his intercession and counsel, and in time a women's monastery was founded near the pillar. At times an unearthly light was seen to radiate from the top of the pillar, accompanied by thunder and lightning. He owned nothing, and once threw his only tunic down to a poor man in need, leaving himself completely exposed to the elements until a recluse dwelling nearby saw his condition and came to his help.

After fifty-three years, Alypius suffered a stroke which paralyzed half his body, but he continued to live on the pillar for another fourteen years, giving up his soul to God at the age of ninety-nine.