"A fellow-countryman and friend of St Basil the Great and other great saints of the fourth century, Amphilochius early forsook the bustle of the world and withdrew to a cave where, as a solitary, he lived in asceticism for forty years. The episcopal throne in Iconium then fell empty, and Amphilochius was chosen in a wonderful way and consecrated as Bishop of Iconium. He was a marvellous shepherd and a great defender of the purity of the Orthodox faith, and took part in the Second Ecumenical Council in 381. He fought zealously against Macedonius, and against the Arians and the Eunomians. He personally begged Theodosius the Great to drive the Arians out of every city in the Empire, but the Emperor did not comply with his request. After a few days, Amphilochius came before the Emperor again. When the bishop was taken into the presence-chamber, the Emperor was sitting on his throne with his son Arcadius, whom he had taken as co-Emperor, sitting at his right hand. Entering the room, Amphilochius did reverence to Theodosius, but ignored Arcadius as though he were not there. Infuriated by this, the Emperor Theodosius commanded that Amphilochius be instantly driven from court. The saint then said to the Emperor: 'Do you see, 0 Emperor, how you do not tolerate a slight paid to your son? In the same way, God the Father does not tolerate dishonour paid to His Son, turning with loathing from those who blaspheme against Him, and being angered at that accursed Arian heresy.' Hearing this, the Emperor understood the reason for Amphilochius's seeming disrespect towards his son, and marvelled at his wisdom and daring. Among many other works, Amphilochius wrote several books on the Faith. He entered into rest in 395 in great old age, and went to immortal life." (Prologue)

Saint Amphilocus was a kinsman of St Gregory the Theologian: his father's sister Nonna (August 5) was St Gregory's mother. Amphilocus himself was a lifelong friend of all three of the great Cappadocian Fathers: Sts Basil, Gregory the Theologian and Gregory of Nyssa.