He was born at Thebes in Egypt, and at a young age left his pious parents, his inheritance and his acquaintances to dwell in the Egyptian desert, devoting himself to ceaseless prayer. After many years, he reputation spread and, despite his desire for solitude, throngs of pilgrims would seek him out for his prayers and counsel. To escape the attentions of men, he did a surprising thing: he abandoned the desert and moved to Constantinople, settling in the Blachernae district, where, amid the bustle of the city, he was able to pass unnoticed, more secure in his solitude than he had been in the caves of Egypt.

As he grew in obedience to the commandments of Christ, the grace of working miracles grew in him, and once again he gradually became known. Once a blind man cast himself before Patapius on the street, and the Saint cured him instantly by calling on the name of Christ. Once he healed a man crippled by dropsy, anointing him with the oil from a vigil lamp and signing him with the Cross.

After blessing the Church for many years with his prayers and miracles, St Patapius fell asleep in peace, and was buried in the church of the Monastery of the Egyptians near Constantinople. In 1904 his precious and incorrupt relics were uncovered in the course of some building at a small monastery near Corinth. From that time the monastery has been dedicated to St Patapius, and many miracles are worked there.