Your cholesterol numbers can drop while your actual heart attack risk barely moves. That gap sits at the center of this week's Own Your Heart Health, where Dr. Regina Druz unpacks what several major 2026 heart trials showed about statin side effects, LDL cholesterol, and how fast real protection shows up.
 
Dr. Regina starts with a simple cut-finger example to show why a lab number improving in twelve weeks does not mean your arteries have changed. From there she breaks down three separate drug trials. One gave a powerful injectable straight to heart attack patients on their way to the cardiac lab, and the results surprised even her own colleagues.
 
She also covers statin muscle pain and what the trial data actually show about muscle complaints, how Repatha side effects compare, why PCSK9 inhibitors work through a completely different pathway from statins, and how long it can take for cholesterol lowering to translate into a measurable change in heart attack or stroke risk.
 
Dr. Regina also explains the 3% 10-year cardiovascular risk threshold discussed in the new guidelines when weighing statin benefits against diabetes risk, plus how she thinks about LDL levels below 50 mg/dL in her own practice. This episode is for educational purposes, not personal medical advice, so bring your own labs and history to your physician before making any changes. Press play to hear how she weighs those numbers against each patient's individual risk and treatment options.
 
Episode Breakdown:
00:00 Welcome Back and a Disappointing Trial Summer
04:41 Major Adverse Cardiac Events Explained
09:26 The Band-Aid Example and HeartWell Toolkit
14:06 Introducing Three Major Cholesterol Trials
18:54 Four Questions to Ask About Any Trial
23:38 The STAREE Trial and Healthy Older Adults
30:27 The AMUNDSEN Trial and an Acute Heart Attack
35:03 The VESALIUS-CV Trial and Primary Prevention Results
41:51 Statin Versus Repatha Questions Patients Ask Most
46:17 How Low Should LDL Go
 
Links:
<a href='https://go.holisticheartcenters.com/apply'>Schedule a Discovery Call</a>
<a href='https://holisticheartcenters.info/hearthealth'>Access Courses and Events</a>
<a href='https://shop.holisticheartcenters.com/'>Get Heartwell Toolkits</a>
<a href='https://calendly.com/heartcenters'>Schedule a Business Meeting</a>
 
 

Connect with Dr. Regina Druz:
<a href='http://holisticheartcenters.com'>Visit the Holistic Heart Centers website</a>
<a href='https://www.facebook.com/holisticheartcenters'>Follow Holistic Heart Centers on Facebook</a>
<a href='https://x.com/heartCenters'>Follow Holistic Heart Centers on X</a>
<a href='https://www.youtube.com/@reginadruzmd'>Subscribe to Dr. Regina on YouTube</a>
<a href='https://www.instagram.com/dr.reginadruz'>Follow Dr. Regina on Instagram</a>
<a href='https://www.tiktok.com/@holisticheartcenters'>Follow Dr. Regina on TikTok</a>
 
 

Podcast production and show notes provided by <a href='http://hivecast.fm'>HiveCast.fm</a>

Your cholesterol numbers can drop while your actual heart attack risk barely moves. That gap sits at the center of this week's Own Your Heart Health, where Dr. Regina Druz unpacks what several major 2026 heart trials showed about statin side effects, LDL cholesterol, and how fast real protection shows up. Dr. Regina starts with a simple cut-finger example to show why a lab number improving in twelve weeks does not mean your arteries have changed. From there she breaks down three separate drug trials. One gave a powerful injectable straight to heart attack patients on their way to the cardiac lab, and the results surprised even her own colleagues. She also covers statin muscle pain and what the trial data actually show about muscle complaints, how Repatha side effects compare, why PCSK9 inhibitors work through a completely different pathway from statins, and how long it can take for cholesterol lowering to translate into a measurable change in heart attack or stroke risk. Dr. Regina also explains the 3% 10-year cardiovascular risk threshold discussed in the new guidelines when weighing statin benefits against diabetes risk, plus how she thinks about LDL levels below 50 mg/dL in her own practice. This episode is for educational purposes, not personal medical advice, so bring your own labs and history to your physician before making any changes. Press play to hear how she weighs those numbers against each patient's individual risk and treatment options. Episode Breakdown: 00:00 Welcome Back and a Disappointing Trial Summer 04:41 Major Adverse Cardiac Events Explained 09:26 The Band-Aid Example and HeartWell Toolkit 14:06 Introducing Three Major Cholesterol Trials 18:54 Four Questions to Ask About Any Trial 23:38 The STAREE Trial and Healthy Older Adults 30:27 The AMUNDSEN Trial and an Acute Heart Attack 35:03 The VESALIUS-CV Trial and Primary Prevention Results 41:51 Statin Versus Repatha Questions Patients Ask Most 46:17 How Low Should LDL Go Links: Schedule a Discovery Call Access Courses and Events Get Heartwell Toolkits Schedule a Business Meeting Connect with Dr. Regina Druz: Visit the Holistic Heart Centers website Follow Holistic Heart Centers on Facebook Follow Holistic Heart Centers on X Subscribe to Dr. Regina on YouTube Follow Dr. Regina on Instagram Follow Dr. Regina on TikTok Podcast production and show notes provided by HiveCast.fm

Your cholesterol numbers can drop while your actual heart attack risk barely moves. That gap sits at the center of this week's Own Your Heart Health, where Dr. Regina Druz unpacks what several major 2026 heart trials showed about statin side effects, LDL cholesterol, and how fast real protection shows up.
&nbsp;
Dr. Regina starts with a simple cut-finger example to show why a lab number improving in twelve weeks does not mean your arteries have changed. From there she breaks down three separate drug trials. One gave a powerful injectable straight to heart attack patients on their way to the cardiac lab, and the results surprised even her own colleagues.
&nbsp;
She also covers statin muscle pain and what the trial data actually show about muscle complaints, how Repatha side effects compare, why PCSK9 inhibitors work through a completely different pathway from statins, and how long it can take for cholesterol lowering to translate into a measurable change in heart attack or stroke risk.
&nbsp;
Dr. Regina also explains the 3% 10-year cardiovascular risk threshold discussed in the new guidelines when weighing statin benefits against diabetes risk, plus how she thinks about LDL levels below 50 mg/dL in her own practice. This episode is for educational purposes, not personal medical advice, so bring your own labs and history to your physician before making any changes. Press play to hear how she weighs those numbers against each patient's individual risk and treatment options.
&nbsp;
Episode Breakdown:
00:00 Welcome Back and a Disappointing Trial Summer
04:41 Major Adverse Cardiac Events Explained
09:26 The Band-Aid Example and HeartWell Toolkit
14:06 Introducing Three Major Cholesterol Trials
18:54 Four Questions to Ask About Any Trial
23:38 The STAREE Trial and Healthy Older Adults
30:27 The AMUNDSEN Trial and an Acute Heart Attack
35:03 The VESALIUS-CV Trial and Primary Prevention Results
41:51 Statin Versus Repatha Questions Patients Ask Most
46:17 How Low Should LDL Go
&nbsp;
Links:
<a href="https://go.holisticheartcenters.com/apply" rel="noopener noreferrer">Schedule a Discovery Call</a>
<a href="https://holisticheartcenters.info/hearthealth" rel="noopener noreferrer">Access Courses and Events</a>
<a href="https://shop.holisticheartcenters.com/" rel="noopener noreferrer">Get Heartwell Toolkits</a>
<a href="https://calendly.com/heartcenters" rel="noopener noreferrer">Schedule a Business Meeting</a>
 
 

Connect with Dr. Regina Druz:
<a href="http://holisticheartcenters.com" rel="noopener noreferrer">Visit the Holistic Heart Centers website</a>
<a href="https://www.facebook.com/holisticheartcenters" rel="noopener noreferrer">Follow Holistic Heart Centers on Facebook</a>
<a href="https://x.com/heartCenters" rel="noopener noreferrer">Follow Holistic Heart Centers on X</a>
<a href="https://www.youtube.com/@reginadruzmd" rel="noopener noreferrer">Subscribe to Dr. Regina on YouTube</a>
<a href="https://www.instagram.com/dr.reginadruz" rel="noopener noreferrer">Follow Dr. Regina on Instagram</a>
<a href="https://www.tiktok.com/@holisticheartcenters" rel="noopener noreferrer">Follow Dr. Regina on TikTok</a>
 
 

Podcast production and show notes provided by <a href="http://hivecast.fm" rel="noopener noreferrer">HiveCast.fm</a>

The Drug Worked. Did You?

Expert insights and actionable steps to reverse and prevent heart disease. Dr. Regina Druz (Cornell/Duke trained MD) is the leading holistic cardiologist, who brings clinical practice wisdom to the science of medicine, enabling listeners to take ownership over their heart health. The episodes focus on the root cause drivers of heart disease, delving deep into metabolic health, hormonal changes, inflammation, toxicities, stress and sleep, and the lifestyle strategies to achieve optimal health, longevity and vitality.

Expert insights and actionable steps to reverse and prevent heart disease. Dr. Regina Druz (Cornell/Duke trained MD) is the leading holistic cardiologist, who brings clinical practice wisdom to the science of medicine, enabling listeners to take ownership over their heart health. The episodes focus on the root cause drivers of heart disease, delving deep into metabolic health, hormonal changes, inflammation, toxicities, stress and sleep, and the lifestyle strategies to achieve optimal health, longevity and vitality.

Own Your Heart Health with Dr. Regina Druz - Trailer

Own your heart health — with clarity, confidence, and science that works.

I’m Dr. Regina Druz, Cornell- and Duke-trained cardiologist and a national leader in holistic, root-cause cardiology.
This channel cuts through outdated advice to bring you expert insights and actionable strategies to reverse and prevent heart disease — naturally and effectively.

You’ll discover:

How to lower blood pressure without confusion

The truth about cholesterol, statins, and alternatives

How metabolic health, hormones, sleep, and stress drive heart disease

Lifestyle solutions that fuel longevity, vitality, and freedom from fear

Through focused playlists and myth-busting content, you’ll gain the tools to: 
✅ Understand your real risks
✅ Take control of your health journey
✅ Live longer, stronger, and better

Subscribe today and join a community where your heart health — and your future — are the priority.

Health & Fitness

Own your heart health — with clarity, confidence, and science that works. I’m Dr. Regina Druz, Cornell- and Duke-trained cardiologist and a national leader in holistic, root-cause cardiology. This channel cuts through outdated advice to bring you expert insights and actionable strategies to reverse and prevent heart disease — naturally and effectively. You’ll discover: How to lower blood pressure without confusion The truth about cholesterol, statins, and alternatives How metabolic health, hormones, sleep, and stress drive heart disease Lifestyle solutions that fuel longevity, vitality, and freedom from fear Through focused playlists and myth-busting content, you’ll gain the tools to: ✅ Understand your real risks ✅ Take control of your health journey ✅ Live longer, stronger, and better Subscribe today and join a community where your heart health — and your future — are the priority.

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