In 2000 and 2011, Drs. Douglas Hanahan and Robert Weinberg authored two papers which stand as the original hallmarks of cancer. Since then, the hallmarks of cancer have been used as a critical framework to develop effective new cancer theranostics. In 2013, López-Otín et al. used the hallmarks of cancer in an effort to construct hallmarks of aging. However, in 2021, Drs. David Gems and João Pedro de Magalhães authored a paper critiquing the hallmarks of aging as a paradigm and urging researchers to move beyond the hallmarks to better understand the process of aging.

On May 9, 2022, Dr. Mikhail Blagosklonny published an original review paper in Aging (Aging-US) Volume 14, Issue 9, entitled, “Hallmarks of cancer and hallmarks of aging.” Dr. Blagosklonny expands on Gems and de Magalhães’ sentiment and writes that “canonic hallmarks of aging are superficial imitations of the hallmarks of cancer.” He takes their work to the next level by offering his own original concept that rearranges the hallmarks of cancer and the hallmarks of aging based on the hierarchical principle and the hyperfunction theory of aging.

“According to hyperfunction theory, aging is a continuation of developmental and reproductive programs that were not turned off upon their completion.”

Full blog - https://aging-us.org/2022/05/an-original-review-on-the-hallmarks-of-cancer-and-aging/

DOI - https://doi.org/10.18632/aging.204082

Corresponding author - Mikhail V. Blagosklonny - [email protected], [email protected]

Press release - https://aging-us.com/news_room/hallmarks-of-cancer-and-hallmarks-of-aging-reviewed

Keywords - aging, oncology, carcinogenesis, geroscience, mTOR, rapamycin, hyperfunction theory

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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