This article investigates the evolutionary history of zoonotic viruses to determine if they must adapt within animal hosts before infecting humans. By analyzing the natural selection patterns of major pathogens like SARS-CoV-2, Ebola, and influenza, researchers found that most viruses do not require significant genetic changes to become capable of human-to-human transmission. Instead, many viruses...去小宇宙查看完整单集简介
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This research introduces a novel ferritin aggregation cell engager (FACE) designed to enhance CAR T cell therapy for patients with refractory leukemias. By utilizing the high expression of CD71 receptors on both cancer and therapeutic cells, this platform stabley anchors to CAR T cells to improve their binding strength and sensitivity to low-density antigens. This approach successfully overcomes a...去小宇宙查看完整单集简介
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The article investigates how β-hydroxybutyrate (BHB), a ketone body produced during a ketogenic diet, enhances the effectiveness of CAR T cell therapy in treating cancer. Through various mouse models and human volunteer data, researchers demonstrated that BHB metabolically reprograms T cells by fueling the TCA cycle and increasing ATP production. This boost in energy leads to superior tumor contro...去小宇宙查看完整单集简介
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This study presents a comprehensive multi-omic analysis of 110 healthy individuals to map the natural variation of the human immune system and its relationship with the gut microbiome. Researchers identified two primary axes of immunological variability driven by interferon response signatures, which are critical for antiviral defense and therapy outcomes. One specific axis, termed Immune and Micr...去小宇宙查看完整单集简介
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Researchers have developed "optovolution," a groundbreaking method for the continuous directed evolution of complex, multi-state protein functions using light-responsive selection pressure. By genetically engineering budding yeast to link a protein of interest to essential cell-cycle regulators, the team created a system where cells only proliferate if the protein correctly switches between "on" a...去小宇宙查看完整单集简介
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This research identifies ROCK2 as a critical driver of liver fibrosis, specifically appearing in elevated levels within the vascular endothelial cells and hepatic stellate cells of diseased livers. Scientists developed TDI01, a highly selective and potent inhibitor designed to block this protein’s activity and restore healthy vessel function. The study demonstrates that TDI01 successfully reduces ...去小宇宙查看完整单集简介
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Researchers have identified α-KG as a key metabolite that naturally combats the pathological vasodilation and erythema associated with rosacea. By activating the OXGR1 receptor in vascular smooth muscle cells, this metabolite triggers a signaling axis that promotes vasoconstriction and reduces skin redness. Detailed cryo-EM imaging revealed a unique bipartite-acid pocket within the receptor, expla...去小宇宙查看完整单集简介
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This research identifies SelO as a conserved mitochondrial enzyme that regulates energy metabolism by hydrolyzing NAD+ into NMN and AMP. Using structural analysis of the bacterial homolog ydiU, scientists discovered that this activity is driven by a unique C-terminal selenocysteine residue and is triggered by increases in mitochondrial pH. The study demonstrates that SelO directly associates with ...去小宇宙查看完整单集简介
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This research study identifies sildenafil as a potential treatment for Leigh syndrome, a currently untreatable and severe mitochondrial disorder. By screening thousands of existing drugs on patient-derived stem cells, scientists discovered that this PDE5 inhibitor can correct cellular defects, such as abnormal mitochondrial membrane potential and impaired calcium regulation. The drug demonstrated ...去小宇宙查看完整单集简介
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The paper introduces stVCR, a generative deep-learning framework designed to reconstruct the continuous spatiotemporal dynamics of single cells from discrete snapshots. Because traditional spatial transcriptomics involves destructive sequencing, it typically produces unpaired "pictures" of biological processes rather than a continuous "video." To bridge this gap, stVCR utilizes dynamic optimal tra...去小宇宙查看完整单集简介
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