Omicron has scrambled everything. Daily Covid cases climb to 237,000, more kids land in hospitals and the CDC changes its isolation guidance to 5 days for asymptomatic cases.

Plus, Democrats run over the same old ground. Is President Biden's agenda dead, or can Joe Manchin be swayed? 

And, Democrats have the slimmest of majorities in the U.S. Senate with the balance of power at 50/50. CNN identifies the ten Senate seats most likely to flip in 2022.

On today’s show: Jonathan Martin of the New York Times, Francesca Chambers White House Correspondent, McClatchy, CNN’s Melanie Zanona, CNN’s Elizabeth Cohen, CNN’s Dr. Leana Wen, Dr. Ali Raja of of Massachusetts General Hospital and Democratic Senator Chris Van Hollen.

Hosted by Phil Mattingly, in for John King.

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