This week we delve into the world of partial heart transplantation when we review a recent paper that discusses the rationale for its potential use in children, particularly in infants. We speak with the work's senior author, Dr. T. Konrad Rajab of the Medical University of South Carolina about the potential benefits of this approach. Who might be a candidate for this approach? What are the theoretical benefits of this approach to transplantation? How many 'partial heart' transplantations have been done to date in the US? What might be different about transplanting 'parts' of hearts rather than entire hearts? Dr. Rajab provides us with his deep insights this week. doi: 10.1111/jocs.17050