This week we review a recent fascinating work from the team in Toronto on a novel large mammalian model of HLHS (in fetal lambs). How did the team develop this model and what insights into the development of HLHS has it afforded? How does reduction in inflow to the developing LV result in changes in cellular proliferation in the LV of the fetal lamb? Which is more important in the development of HLHS - genetics or flow patterns? Is this a false dichotomy? Does this novel model provide insights into outcomes thus far observed in fetal interventions for HLHS and aortic stenosis in humans? We speak with the senior author of this week's work, Professor Rajiv Chaturvedi of the University of Toronto about this potentially groundbreaking new model and some of the insights it has provided.

https://doi.org/10.1038/s42003-023-05132-2