Penn interviews and catches up with his oddly close old friend LOD. Can they both leave the conversation a liberal or both leave a libertarian? We hear about O' Donnell passing up a chance to make millions of American dollars in DC and we get a behind-the-scenes perspective into The West Wing, Senator Moynihan's career and LOD's MSNBC show.

Penn interviews and catches up with his oddly close old friend LOD. Can they both leave the conversation a liberal or both leave a libertarian? We hear about O' Donnell passing up a chance to make millions of American dollars in DC and we get a behind-the-scenes perspective into The West Wing, Senator Moynihan's career and LOD's MSNBC show.

Penn, Matt talk with Dustin about his recent gig in China and surviving life there as a round eye. Penn discovers that making movies and making friends are not mutually exclusive. Penn reveals his dad's early showbiz advice and returns the favor when he meets a young 9 year magic genius, Alex Newberg backstage at the Rio.

Penn and Matt discuss gays rights and free speech with 'Kindly Inquisitors' author Jonathan Rauch. Penn has more issues with popular music lyrics and a major beef with the FDA. Dr. Ed comes on to chat about cancer and heart disease from the frontier of modern medicine.

Taped at the Huge Improv Theater in Minneapolis.

Penn tells some Lou Reed stories.

Penn learns to cook for TV. Movies that suck the life out of us, and Matt the Mailman.

Lenny Bruce, Malala, The Led Zepplin, and a victim of John Edward gets a tough lesson.

Adam Rifkin visits to talk about his movies and working with Penn on 'Director's Cut.'

Our 1st Amendment Bob Corn-Revere talks about revenge porn. Penn meets the world's greatest drummer, and Jonesy visits to tell us about his new album.